The characterization of two novel neotropical primate papillomaviruses supports the ancient within-species diversity model

D’arc, Mirela; Moreira, Filipe Romero Rebello; Dias, Cecília Azevedo; Souza, Antonizete R; Seuánez, Héctor N.; Soares, Marcelo A.; Tavares, Maria Clotilde Henriques; Santos, André F.

doi:10.1093/ve/veaa036

Cited by 13 publications

(20 citation statements)

References 57 publications

(73 reference statements)

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“…Phylogenetic analysis of the new genome sequences suggests a topological pattern consistent with a previously proposed model for the diversification of multiple viral families, the within-species diversity followed by codivergence model 16,40–42 . Under this model, viral lineages diversify either alongside their host species or through a speciation process within a single host, occasionally caused by niche adaptation to specific cell types or tissues.…”

Section: Discussionsupporting

confidence: 81%

Discovery of two novel Torque Teno viruses in Callithrix penicillata provides insights on Anelloviridae diversification dynamics

Cosentino

D’arc

Moreira

et al. 2022

Preprint

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The development of high throughput sequencing (HTS) technologies and metagenomics protocols deeply impacted the discovery of viral diversity. Moreover, the comprehension of evolution and immunology of the Neotropical primates (NP) and their susceptibility to infectious diseases are central for the characterization of the scope of etiological agents that may impact global health, due to their evolutionary proximity to Old World primates, including humans. In the present work, novel anelloviruses were detected and characterized through HTS protocols in the NP Callithrix penicillata, the common black-tufted marmoset. De novo assembly of generated sequences was carried out and a total of 15 contigs were identified with complete Anelloviridae ORF1 gene, two of them including a flanking GC-rich region, confirming the presence of two whole novel genomes of ~3kb. The identified viruses were monophyletic within the Epsilontorquevirus genus, a lineage harboring previously reported anelloviruses infecting hosts from the Cebidae family. The genetic divergence found in the new viruses characterized two novel species, named Epsilontorquevirus callithrichensis I and II. The phylogenetic pattern inferred for the Epsilontorquevirus genus was consistent with the topology of their host species tree, echoing a virus-host diversification model observed in other viral groups. This study expands the host span of Anelloviridae and provides insights into their diversification dynamics, highlighting the importance of sampling animal viral genomes to obtain a clearer depiction of their long-term evolutionary processes.

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Section: Discussionsupporting

confidence: 81%

Discovery of two novel Torque Teno viruses in Callithrix penicillata provides insights on Anelloviridae diversification dynamics

Cosentino

D’arc

Moreira

et al. 2022

Preprint

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“…Transmission occurs through the close contact that these animals have developed with humans, facilitated by the habit of offering food, since the virus can be transmitted through contaminated saliva, aerosols and fomites. Transmission can also occur spontaneously between marmosets within the same group [133,135]. Affected animals are usually found dead or with severe neurological symptoms, resulting from virus-induced encephalitis [134].…”

Section: Other Pathogens Of Callithrixmentioning

confidence: 99%

“…Affected animals are usually found dead or with severe neurological symptoms, resulting from virus-induced encephalitis [134]. The virus also causes death from meningitis [134], erosions and ulcers in the oral cavity, in addition to hemorrhages and focal necrosis in several organs [135].…”

Section: Other Pathogens Of Callithrixmentioning

confidence: 99%

An Introduction to the Callithrix Genus and Overview of Recent Advances in Marmoset Research

Malukiewicz¹,

Boere²,

Oliveira³

et al. 2020

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We provide here a current overview of marmoset (Callithrix) evolution, hybridization, species biology, basic/biomedical research, and conservation initiatives. Composed of two subgroups, the aurita group (C. aurita and C. flaviceps) and the jacchus group (C. geoffroyi, C. jacchus, C. kuhlii and C. penicillata), this relatively young primate radiation is endemic to the Brazilian Cerrado, Caatinga, and Atlantic Forest biomes. Significant impacts on Callithrix within these biomes resulting from anthropogenic activity include: (1) population declines, particularly for the aurita group; (2) widespread geographic displacement, biological invasions, and range expansions of C. jacchus and C. penicillata; (3) anthropogenic hybridization; and (4) epizootic Yellow Fever and Zika viral outbreaks. A number of Brazilian legal and conservation initiatives are now in place to protect the threatened aurita group and increase research into them. Due to their small size and fast life history, marmosets are prized biomedical models. As a result, there are increasingly sophisticated genomic Callithrix resources available and burgeoning marmoset functional, immuno-, and epi- genomic research. In both the laboratory and the wild, marmosets have given us insight into cognition, social group dynamics, human disease, and pregnancy. Callithrix jacchus and C. penicillata are emerging Neotropical primate models for arbovirus disease, including Dengue and Zika. Wild marmoset populations are helping us understand sylvatic transmission and human spillover of Zika and Yellow Fever viruses. All of these factors are positioning marmosets as preeminent models to facilitate understanding of facets of evolution, hybridization, conservation, human disease, and emerging infectious diseases.

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“…To date, more than 200 types of HPV have been described. Representatives of the Alpha genus, which mainly infect the mucous membranes of the anogenital tract, oral cavity, pharynx, and larynx [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Phototheranostics of Cervical Neoplasms with Chlorin e6 Photosensitizer

Gilyadova

Ищенко

Shiryaev

et al. 2022

Cancers

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(1) Purpose: Improving the treatment effectiveness of intraepithelial neoplasia of the cervix associated with human papillomavirus infection, based on the application of the method of photodynamic therapy with simultaneous laser excitation of fluorescence to clarify the boundaries of cervical neoplasms. (2) Methods: Examination and treatment of 52 patients aged 22 to 53 years with morphologically and cytologically confirmed mild to severe intraepithelial cervix neoplasia, preinvasive, micro-invasive, and squamous cell cervix carcinoma. All patients were carriers of human papillomavirus infection. The patients underwent photodynamic therapy with simultaneous laser excitation of fluorescence. The combined use of video and spectral fluorescence diagnostics for cervical neoplasms made it possible to control the photodynamic therapy process at all stages of the procedure. Evaluation of the photodynamic therapy of intraepithelial cervical neoplasms was carried out with colposcopic examination, cytological conclusion, and morphological verification of the biopsy material after the photodynamic therapy course. The success of human papillomavirus therapy was assessed based on the results of the polymerase chain reaction. (3) Results. The possibility of simultaneous spectral fluorescence diagnostics and photodynamic therapy using a laser source with a wavelength of 660 nm has been established, making it possible to assess the fluorescence index in real-time and control the photobleaching of photosensitizers in the irradiated area. The treatment of all 52 patients was successful after the first photodynamic therapy procedure. According to the PCR test of the discharge from the cervical canal, the previously identified HPV types were not observed in 48 patients. Previously identified HPV types were absent after repeated PDT in four patients (CIN III (n = 2), CIS (n = 2)). In 80.8% of patients, regression of the lesion was noted. (4) Conclusions. The high efficiency of photodynamic therapy with intravenous photosensitizer administration of chlorin e6 has been demonstrated both in relation to eradication therapy of human papillomavirus and in relation to the treatment of intraepithelial lesions of the cervix.

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The characterization of two novel neotropical primate papillomaviruses supports the ancient within-species diversity model

Cited by 13 publications

References 57 publications

Discovery of two novel Torque Teno viruses in Callithrix penicillata provides insights on Anelloviridae diversification dynamics

Discovery of two novel Torque Teno viruses in Callithrix penicillata provides insights on Anelloviridae diversification dynamics

An Introduction to the Callithrix Genus and Overview of Recent Advances in Marmoset Research

Phototheranostics of Cervical Neoplasms with Chlorin e6 Photosensitizer

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