The Characterization of Chitosan Nanoparticles by Raman Spectroscopy

Ren, Xiao; Liu, Qing Shan; Feng, Hui; Yin, Xiao Ying

doi:10.4028/www.scientific.net/amm.665.367

Cited by 36 publications

(21 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The difference of the band locations between the literature and this study might be due to the interaction between the charged amine groups and the phosphate units. The Raman spectra in Figure 7b,c show that the bands of the bending (1596 cm −1 ) and stretching (3305 cm −1 ) vibrations of NH 2 disappeared for the coated fibres, and this was attributed to the protonation of amine groups, which correlated well with the IR results [41].…”

Section: Ftir and Raman Analysessupporting

confidence: 76%

Chitosan as a Coupling Agent for Phosphate Glass Fibre/Polycaprolactone Composites

Tan

Rudd

Parsons

et al. 2018

Fibers

View full text Add to dashboard Cite

This study shows that chitosan (CS) could be highly useful as a coupling agent in phosphate glass fibre/polycaprolactone (PGF/PCL) composites, as it improved the interfacial shear strength by up to 78%. PGFs of the composition 45P2O5–5B2O3–5Na2O–24CaO–10MgO–11Fe2O3 were dip-coated with CS (with a degree of deacetylation >80%) dissolved in acetic acid solution (2% v/v). Different CS concentrations (3–9 g L−1) and coating processes were investigated. Tensile and fragmentation tests were conducted to obtain the mechanical properties of the single fibres and interfacial properties of the PGF/PCL composites, respectively. It was observed that post-cleaning, the treated fibres had their tensile strength reduced by around 20%; however, the CS-coated fibres experienced strength increases of up to 1.1–11.5%. TGA and SEM analyses were used to confirm the presence of CS on the fibre surface. FTIR, Raman, and X-ray photoelectron spectroscopy (XPS) analyses further confirmed the presence of CS and indicated the protonation of CS amine groups. Moreover, the nitrogen spectrum of XPS demonstrated a minimum threshold of CS coating required to provide an improved interface.

show abstract

Section: Ftir and Raman Analysessupporting

confidence: 76%

Chitosan as a Coupling Agent for Phosphate Glass Fibre/Polycaprolactone Composites

Tan

Rudd

Parsons

et al. 2018

Fibers

View full text Add to dashboard Cite

show abstract

“…In the case of systems in the weight ratios 1:5 w / w and 1:10 w / w predominant bands derived from chitosan. We can distinguish such bands as 807 cm −1 (out-of-plane CH deformations of rings), 840 cm −1 (C–O–C stretching vibrations), 974 cm −1 , 1221 cm −1 , 1331 cm −1 (C–H stretching vibrations), 1155 cm −1 (C–N stretching vibrations) and 1461 cm −1 (CH 3 bending vibrations) [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Chitosan as Valuable Excipient for Oral and Topical Carvedilol Delivery Systems

Sip

Paczkowska-Walendowska

Rosiak

et al. 2021

Pharmaceuticals

View full text Add to dashboard Cite

Chitosan is a valued excipient due to its biocompatibility properties and increasing solubility of poorly water-soluble drugs. The research presented in this paper concerns the preparation of binary combinations of chitosan (deacetylated chitin) with carvedilol (beta-blocker) to develop a formulation with a modified carvedilol release profile. As part of the research, six physical mixtures of chitosan with carvedilol were obtained and identified by spectral (PXRD, FT-IR, and Raman), thermal (DSC), and microscopic (SEM) methods. The next stage of the research estimated the profile changes and the dissolution rate for carvedilol in the obtained drug delivery systems; the reference sample was pure carvedilol. The studies were conducted at pH = 1.2 and 6.8, simulating the gastrointestinal tract conditions. Quantitative changes of carvedilol were determined using the developed isocratic UHPLC-DAD method. Established apparent permeability coefficients proved the changes in carvedilol’s permeability after introducing a drug delivery system through membranes simulating the gastrointestinal tract and skin walls. A bioadhesive potential of carvedilol–chitosan systems was confirmed using the in vitro model. The conducted research and the obtained results indicate a significant potential of using chitosan as an excipient in modern oral or epidermal drug delivery systems of carvedilol.

show abstract

“…Table 1 and Table 2 contain a list of the most important bands in vibrational spectra, with corresponding assignments presented in Figure 1 A,B (ATR FT-IR spectra, Table 1 ) and Figure 1 C,D (Raman spectra, Table 2 ) [ 12 , 14 , 15 , 16 , 17 ]. Both ATR FT-IR and Raman spectra of the individual components, chitosan and 1,3-β- d -glucan ( Figure 1 A,C, respectively), allow for the unambiguous identification of these compounds and are consistent with the literature data [ 11 , 18 ].…”

Section: Resultsmentioning

confidence: 99%

Surface Chemical and Morphological Analysis of Chitosan/1,3-β-d-Glucan Polysaccharide Films Cross-Linked at 90 °C

Gieroba

Sroka-Bartnicka

Kazimierczak

et al. 2022

IJMS

View full text Add to dashboard Cite

The cross-linking temperature of polymers may affect the surface characteristics and molecular arrangement, which are responsible for their mechanical and physico-chemical properties. The aim of this research was to determine and explain in detail the mechanism of unit interlinkage of two-component chitosan/1,3-β-d-glucan matrices gelled at 90 °C. This required identifying functional groups interacting with each other and assessing surface topography providing material chemical composition. For this purpose, various spectroscopic and microscopic approaches, such as attenuated total reflection Fourier transform infrared spectroscopy (ATR FT-IR), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM), were applied. The results indicate the involvement mainly of the C-C and C-H groups and C=O⋯HN moieties in the process of biomaterial polymerization. Strong chemical interactions and ionocovalent bonds between the N-glucosamine moieties of chitosan and 1,3-β-d-glucan units were demonstrated, which was also reflected in the uniform surface of the sample without segregation. These unique properties, hybrid character and proper cell response may imply the potential application of studied biomaterial as biocompatible scaffolds used in regenerative medicine, especially in bone restoration and/or wound healing.

show abstract

The Characterization of Chitosan Nanoparticles by Raman Spectroscopy

Cited by 36 publications

References 4 publications

Chitosan as a Coupling Agent for Phosphate Glass Fibre/Polycaprolactone Composites

Chitosan as a Coupling Agent for Phosphate Glass Fibre/Polycaprolactone Composites

Chitosan as Valuable Excipient for Oral and Topical Carvedilol Delivery Systems

Surface Chemical and Morphological Analysis of Chitosan/1,3-β-d-Glucan Polysaccharide Films Cross-Linked at 90 °C

Contact Info

Product

Resources

About