The characterization and evaluation of cisplatin-loaded magnetite–hydroxyapatite nanoparticles (mHAp/CDDP) as dual treatment of hyperthermia and chemotherapy for lung cancer therapy

Huang, Jia-Hong; Chen, Min Hua; Kuo, Wei‐Ting; Sun, Yuxuan; Lin, Fa‐Hsuan

doi:10.1016/j.ceramint.2014.10.054

Cited by 39 publications

(21 citation statements)

References 33 publications

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“…It is well known that the interest in iron oxides nanoparticles investigation has grown radically during last decades regarding to the potential of these systems in several relevant fields such as medicine, environmental remediation and electronics [1,2].…”

Section: Introductionmentioning

confidence: 99%

Simple and novel strategies to achieve shape and size control of magnetite nanoparticles intended for biomedical applications

Azcona

Zysler

Lassalle

2016

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Monodisperse magnetite nanoparticles (MNPs) with controlled sizes and shapes were prepared. The synthesis was carried out by traditional and inverted co-precipitation method with some modifications such as presence of visible light, room temperature and absence of inert atmosphere. Sodium dodecyl sulphate (SDS) was employed as stabilizer. The mentioned experimental parameters were conveniently adjusted to obtain suitable MNPs, to be efficiently employed in biomedical applications. In particular the size, shape, surface charge and magnetic properties were evaluated. MNPs were thoroughly characterized. From characterization data, it emerged that the inverted co-precipitation in presence of visible light rendered mainly nanorods. Modifying the SDS concentration the shape was tuned from nanorods to nanospheres and finally, at higher concentrations, nanocubes were obtained. All prepared formulations resulted hydrophilic. This property was justified in terms of the stabilization mechanism of SDS. Stability of MNPs aqueous dispersions was evaluated regarding to the variation of hydrodynamic diameter as a function of the time. In this regard, all the formulations resulted stable during, at least, 30 days. The prepared nanosystems exhibited satisfactory magnetic properties with saturation magnetization slightly lower than raw magnetite. The combination of size, shape, surface charge, hidrophilicity and magnetic behaviour make the magnetic nanosystems here obtained highly suitable and promising to diagnostic and therapeutic applications.

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Section: Introductionmentioning

confidence: 99%

Simple and novel strategies to achieve shape and size control of magnetite nanoparticles intended for biomedical applications

Azcona

Zysler

Lassalle

2016

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…More recently however, experimental treatments have been tried in which magnetic nanoparticles (mNPs) have been used alone and in conjunction with chemotherapeutic agents [4, 5]. The use of magnetic nanoparticles (mNPs) mainly comprised of iron oxide due to biocompatibility and low toxicity has been investigated [6–10].…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study Into the Use of FDG-mNP as an Alternative Approach in Neuroblastoma Cell Hyperthermia

Subramanian

Pearce

Guldu

et al. 2016

IEEE Trans.on Nanobioscience

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Purpose Herein, we present a pilot study concerning the use of fluorodeoxy glucose conjugated magnetite nanoparticles as a potential agent in magnetic nanoparticle mediated neuroblastoma cancer cell hyperthermia. This approach makes use of the ‘Warburg effect’, utilising the fact that cancer cells have a higher metabolic rate than normal cells. Materials and methods FDG-mNP were synthesized, then applied to the SH-SY5Y neuroblastoma cancer cell line and exposed to an AC magnetic field. 3D Calorimetry was performed on the FDG-mNP compound. Simulations were performed using SEMCAD X software using Thelonious, (an anatomically correct male child model) in order to understand more about the end requirements with respect to cancer cell destruction. Results We investigated FDG-mNP mediated neuroblastoma cytotoxicity in conjunction with AC magnetic field exposure. Results are presented for 3D FDG-mNP SARmnp (10.86 ± 0.99 W/g of particles) using a therapeutic dose of 0.83 mg/mL. Human model simulations suggest that 43 W/kg SARTheo would be required to obtain 42 °C within the centre of a liver tumour (Tumour size, bounding box x=64, y=61, z=65 [mm]), and that the temperature distribution is inhomogeneous within the tumour. Conclusion Our study suggests that this approach could potentially be used to increase the temperature within cells that would result in cancer cell death due to hyperthermia. Further development of this research will also involve using whole tumours removed from living organisms in conjunction with magnetic resonance imaging and positron emission tomography.

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“…However, there is a significant issue with current translational research efforts in magnetic hyperthermia, in that the nature of the cell death pathways -as opposed to outcomes -that are triggered by MFH have until now been unclear. This is because almost all previously reported in vitro and/or ex vivo assays have relied exclusively on post hoc assessments of cell viability or morphology, as determined after the application of the time-varying field [5][6][7][8][9][10][11]. To our knowledge, the only exception to this rule, to date, was a very recent publication on real-time imaging of MFH experiments using a confocal microscope [12] -albeit that the focus of that work was on the immediate consequences of the MFH during treatment, and on lysosome membrane permeabilization events, rather than on longer term consequences to the cell as a whole.…”

mentioning

confidence: 99%

Real-Time Tracking of Delayed-Onset Cellular Apoptosis Induced By Intracellular Magnetic Hyperthermia

Blanco-Andujar

Ortega

Southern

et al. 2015

Nanomedicine (Lond.)

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The characterization and evaluation of cisplatin-loaded magnetite–hydroxyapatite nanoparticles (mHAp/CDDP) as dual treatment of hyperthermia and chemotherapy for lung cancer therapy

Cited by 39 publications

References 33 publications

Simple and novel strategies to achieve shape and size control of magnetite nanoparticles intended for biomedical applications

Simple and novel strategies to achieve shape and size control of magnetite nanoparticles intended for biomedical applications

A Pilot Study Into the Use of FDG-mNP as an Alternative Approach in Neuroblastoma Cell Hyperthermia

Real-Time Tracking of Delayed-Onset Cellular Apoptosis Induced By Intracellular Magnetic Hyperthermia

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