The Characteristics of Reverse Tolerance to the Ambulation-Increasing Effect of Cocaine After Repeated Administration in Mice

Differential Sensitization to Ambulation-Increasing Effect of Methamphetamine after Repeated Administration to Mice in Activity Cages of Different Sizes

“…In addition, there was almost no development of enhancement in animals that had been pre treated repeatedly with the drugs and confined in a narrow environment (glass jar of 5.5 cm in diameter and 15 cm height) (2)(3)(4)(5). These findings suggest that such a sensitization phe nomenon is strongly affected by the dimen sions of the activity cage in which the animal move about under the drug effect.…”

“…periment, changes in the sensitization were investigated in mice after repeated pre treatments with MAP at 2 mg/kg at 3 4 day interval for 4 times in activity cages of 5 different sizes (5,10,15,30 and 40 cm in diameter) in comparison with that of in the 20 cm-cage. AIE obtained after MAP in the 5 and 10-cm cages was not enhanced, whereas AIE was significantly enhanced in the cages of more than 15 cm in diameter.…”