The Characteristics of Newly Formed Collagen during Ageing

Effect of Alloxan Diabetes on the Characteristics of Collagen of Cotton Pellet Granuloma and Dorsal Skin of Swiss Mice

“…The growth of connective tissue can be induced by various techniques such as the injection of carrageenin [Cmuchalova and Chvapil, 1963] or the subcutaneous implanta tion of either polystyrene sponge [Hruza and Hlavackova, 1963] or cotton pellet granu loma [Chakraborty et al, 1965;Balasubramanian and Bacchawat, 1961). The rate of growth of such tissue is age-dependent [Palnaik, 1967;Hruza and Hlavackova, 1963], In the present studies, young Swiss mice were used to test if alloxan affects the newly formed collagen in cotton pellet granuloma concomitantly with its effect on the collagen of existing body tissues.…”

“…The rate of growth of such tissue is age-dependent [Palnaik, 1967;Hruza and Hlavackova, 1963], In the present studies, young Swiss mice were used to test if alloxan affects the newly formed collagen in cotton pellet granuloma concomitantly with its effect on the collagen of existing body tissues. That the mice were, in fact, rendered dia betic by alloxan treatment was clearly indi cated by higher blood-glucose level.…”