The characteristics of acute necrotizing pancreatitis in different age stages: An MRI study

Yang, Dan; Zuo, Hou Dong; Wu, Chang Qiang; Chen, Tian Wu; Xue, Huadan; Jin, Zheng; Zhang, Xiao Ming

doi:10.1016/j.ejrad.2019.108752

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…The current study's results agreed with those of (Yang et al, 2020) in sheep and goats. However, they disagree with those of (Sreeranjini et al, 2020) Brazilian sloths, who claimed that the pancreas possessed a thick capsule devoid of elastic fibers.…”

Section: Resultssupporting

confidence: 89%

Histochemical Study of Immature Blackbuck Pancreas in Al-Najaf, Iraq

Al-Kelaby,

Al Kaabi,

Al-Hussaniy

et al. 2024

American Journal of Animal and Veterinary Sciences

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The histological makeup of the pancreas in immature male and female Iraqi blackbuck (Caprus hircus) has not been well described. We aimed to describe the histological features of the pancreas in immature male and female Iraqi blackbuck. Samples were collected from 20 immature male and female animals' pancreas, obtained from the Al-Najaf slaughterhouse. The samples were fixed in 10% neutral buffered formalin, processed using standard histological methods, and stained with Gomori's, weigart's, Harris hematoxylin, eosin, and maldonad's stains (LOBA Chemie laboratory reagents and fine chemicals). The study showed that the goblet cells were underdeveloped and crowded, while the centroacinar cell's position and characteristics might indicate that these cells are involved in the transport of fluids and secretions within the duct system. The mean distribution of the total number of Langerhans islets' cells was similar across all groups (males and females), with no discernible variances. Morphometric analysis of the Langerhans islets revealed no differences in the distribution of islets between any of the studied groups in the right, left, or body of the pancreas. The histological analysis of the pancreas in immature male and female Iraqi blackbuck showed unique features regarding the arrangement of the islets of Langerhans, goblet cells, and centroacinar cells. These findings could contribute to a better understanding of the physiology and pathology of the pancreas in this species.

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Section: Resultssupporting

confidence: 89%

Histochemical Study of Immature Blackbuck Pancreas in Al-Najaf, Iraq

Al-Kelaby,

Al Kaabi,

Al-Hussaniy

et al. 2024

American Journal of Animal and Veterinary Sciences

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“…This may also be the reason why there were no significant differences in sex, age, or etiology between the patients with EXPN and APFC in either cohort in our study. However, Yang et al 37 reported that age was of great significance for the development of necrotizing pancreatitis. The etiology has also been considered to be associated with AP severity 38 .…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging–Based Radiomics Models to Predict Early Extrapancreatic Necrosis in Acute Pancreatitis

et al. 2021

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The aim of the study was to investigate radiomics models based on magnetic resonance imaging (MRI) for predicting early extrapancreatic necrosis (EXPN) in acute pancreatitis.Methods: Radiomics features were extracted from T2-weighted images of extrapancreatic collections and late arterial-phase images of the pancreatic parenchyma for 135 enrolled patients (94 in the primary cohort, including 47 EXPN patients and 41 in the validation cohort, including 20 EXPN patients). The optimal features after dimension reduction were used for radiomics modeling through a support vector machine. A clinical model, the MR severity index score, and extrapancreatic inflammation on MRI were evaluated.Results: Twelve optimal features from the extrapancreatic collection images and 10 from the pancreatic parenchyma images were selected for modeling. The pancreatic parenchyma-based and extrapancreatic collection-based radiomics models showed good predictive accuracy in both the training and validation cohorts. The areas under the curve of the extrapancreatic collection-based radiomics model (0.969 and 0.976) were consistent with those of the pancreatic parenchyma-based model (0.931 and 0.921) for both cohorts and better than those of the clinical model and imaging scores for both cohorts. Conclusions:The MRI-based radiomics models of both the extrapancreatic collections and the pancreatic parenchyma had excellent predictive performance for early EXPN.

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“…Moreover, Yang et al studied the characteristics of acute necrotizing pancreatitis (ANP) in different age stages using MRI. The elderly group exhibited the highest prevalence of ANP ( p < 0.05) and more frequently suffered from extensive extra-pancreatic involvement such as thrombus formation ( p = 0.004) [ 69 ]. Meta-analysis showed that senescence also influences the clinical course and prognosis of AP [ 64 ].…”

Section: The Role Of Senescence In Types Of Pancreatic Diseasesmentioning

confidence: 99%

Changes in Pancreatic Senescence Mediate Pancreatic Diseases

Bian

Xiao

et al. 2023

IJMS

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In recent years, there has been a significant increase in age-related diseases due to the improvement in life expectancy worldwide. The pancreas undergoes various morphological and pathological changes with aging, such as pancreatic atrophy, fatty degeneration, fibrosis, inflammatory cell infiltration, and exocrine pancreatic metaplasia. Meanwhile, these may predispose the individuals to aging-related diseases, such as diabetes, dyspepsia, pancreatic ductal adenocarcinoma, and pancreatitis, as the endocrine and exocrine functions of the pancreas are significantly affected by aging. Pancreatic senescence is associated with various underlying factors including genetic damage, DNA methylation, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and inflammation. This paper reviews the alternations of morphologies and functions in the aging pancreas, especially β-cells, closely related to insulin secretion. Finally, we summarize the mechanisms of pancreatic senescence to provide potential targets for treating pancreatic aging-related diseases.

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The characteristics of acute necrotizing pancreatitis in different age stages: An MRI study

Cited by 4 publications

References 34 publications

Histochemical Study of Immature Blackbuck Pancreas in Al-Najaf, Iraq

Histochemical Study of Immature Blackbuck Pancreas in Al-Najaf, Iraq

Magnetic Resonance Imaging–Based Radiomics Models to Predict Early Extrapancreatic Necrosis in Acute Pancreatitis

Changes in Pancreatic Senescence Mediate Pancreatic Diseases

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