The Characteristics and Prognostic Effect of E-Cadherin Expression in Colorectal Signet Ring Cell Carcinoma

Wang, Renjie; Ma, Xiaolong; Li, Yaqi; He, Yiping; Huang, Dan; Cai, Sanjun; Peng, Junjie

doi:10.1371/journal.pone.0160527

Cited by 28 publications

(31 citation statements)

References 36 publications

(36 reference statements)

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“…In agreement with previous colorectal SRCC data, 4 , 5 , 7 – 9 colorectal MAC-SRC patients were commonly diagnosed at an advanced stage in this study, with distant metastasis or lymph node metastasis. In a previous study examining 59 patients, 58 (98.3%) individuals had T3/T4 lesions, 52 (88.1%) showed lymph node metastasis, and 14 (23.7%) had distant metastasis.…”

Section: Discussionsupporting

confidence: 93%

“…In a previous study examining 59 patients, 58 (98.3%) individuals had T3/T4 lesions, 52 (88.1%) showed lymph node metastasis, and 14 (23.7%) had distant metastasis. 5 In line with previous reports, almost all cases (96.3%) in the current study were diagnosed as stage T3 or T4, with 91.4% and 29.3% showing lymph node involvement and distant metastasis, respectively. Early diagnosis might be challenging because colorectal MAC-SRC is merely asymptomatic in the initial stage.…”

Section: Discussionsupporting

confidence: 92%

“…Moreover, SRCC is considered an independent predictive factor of dismal prognosis. 14 , 15 Reportedly, the 5-year OS rate of colorectal SRCC ranges from 0 to 31%, 5 , 13 , 15 – 17 obviously lower than that of the conventional colorectal MAC (range 48.0–69.0%). 9 , 13 , 17 In the current analysis, the 5-year OS rate in colorectal MAC-SRC patients was 42.5%, falling between MAC and SRCC rates.…”

Section: Discussionmentioning

confidence: 97%

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Characteristics and prognostic factors of colorectal mucinous adenocarcinoma with signet ring cells

Kong

Zhang

Huang

et al. 2017

CMAR

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BackgroundColorectal signet ring cell (SRC) carcinoma occurs rarely with a poor prognosis. The present study assessed the prognostic factors and predictive value of SRC ratio in colorectal mucinous adenocarcinoma (MAC) with SRCs (MAC-SRC).Patients and methodsA total of 95 consecutive colorectal MAC-SRC patients, confirmed pathologically from February 1987 to December 2015, were analyzed retrospectively in our institute. Clinical characteristics, pathological grade, TNM staging, and SRC ratio were assessed to identify the prognostic factors related to progression-free survival (PFS) and overall survival (OS). SPSS 22.0 was used for statistical analyses.ResultsThe median follow-up time was 29.7 months (range 0.8–165). Meanwhile, 5-year PFS and OS rates were 25.6% (95% confidence interval [CI] 16.192–35.008%) and 40.5% (95% CI 29.524–51.476%), respectively. Among the 81 patients who underwent surgery, 78 (96.3%) were diagnosed as stage T3 or T4; 74 (91.4%) showed lymph node involvement, and 27 (29.3%) presented distant metastasis. Metastases of the peritoneal cavity and ovaries were observed commonly in colorectal MAC-SRC. In the multivariate Cox regression model, SRC ratio ≥35%, absence of preoperative radiotherapy, and distant metastasis were independent predictors of PFS. Furthermore, SRC ratio ≥35%, absence of preoperative chemotherapy (pre-CT), and distant metastasis were independent risk factors for poor prognosis.ConclusionA long-term follow-up of colorectal MAC-SRC reveals that it is a rare subtype of colorectal MAC with a dismal prognosis. Furthermore, SRC ratio, pre-CT, and M stage seem to affect OS independently.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 97%

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Characteristics and prognostic factors of colorectal mucinous adenocarcinoma with signet ring cells

Kong

Zhang

Huang

et al. 2017

CMAR

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“…Yang et al [13] have suggested that patients with in-frame fusion genes containing the RhoGAP domain represent the aggressive subset of DGCs. Wang et al [30] have suggested that loss of E-cadherin is associated with poor prognosis. However, there is no clear consensus regarding the chemosensitivity and prognosis of cell-adherens junction molecules in mDGCs.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of CLDN18.2 Expression in Diffuse-Type Metastatic Gastric Cancer

Kim

Shin

Park

et al. 2020

Preprint

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Background Isoform 2 of the tight junction protein claudin-18 (CLDN18.2) is a potential target of gastric cancer treatment. A treatment targeting CLDN18.2 has shown promising results in gastric cancer. We investigated the clinical significance of CLDN18.2 and other cell-adherens junction molecules (Rho GTPase-activating protein [RhoGAP] and E-cadherin) in metastatic diffuse-type gastric cancer (mDGC).Methods We evaluated CLDN18.2, RhoGAP, and E-cadherin expression by performing two-plex immunofluorescence and quantitative data analysis of H-scores of 77 consecutive mDGC patients who received first-line, platinum-based chemotherapy between March 2015 and February 2017.Results CLDN18.2 and E-cadherin expression was significantly reduced in patients with peritoneal metastasis (PM) compared with those without PM at the time of diagnosis (P=0.010 and 0.013, respectively), while it was significantly higher in patients who never exhibited PM from diagnosis to death than in those who did (p=0.001 and 0.003, respectively). Meanwhile, CLDN18.2 and E-cadherin were expressed at significantly higher levels in patients with bone metastasis than in those without it (p=0.010 and 0.001, respectively). We identified a positive correlation between the expression of CLDN18.2 and E-cadherin (p < 0.001), RhoGAP and CLDN18.2 (p=0.004), and RhoGAP and E-cadherin (p=0.001). CDLN18.2, RhoGAP, and E-cadherin expression was not associated with chemotherapy response and survival.Conclusions CLDN18.2 expression was reduced in PM but significantly intact in bone metastasis. Furthermore, a positive correlation was identified between the expression of CLDN18.2 and other adherens junction molecules, which has clinical implications for mDGC and PM pathogenesis.

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“…The most recent studies, however, reported that age showed no correlation with survival in patients with colorectal SRCC. Wang et al [24] analyzed 59 patients with colorectal SRCC and found that age (40 years old as cutoff value) was not a prognostic factor for survival. Kakar and Smyrk [25] reported that age (70 years old as cutoff value) was not significantly associated with survival in a study including 72 patients with SRCC of the colorectum.…”

Section: Discussionmentioning

confidence: 99%

Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis

Huang

Chen

et al. 2016

Gastroenterology Research and Practice

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Background. In general, younger age is associated with better survival in patients with colon cancer. In this study, we aim to analyze the impact of age on cancer-specific survival (CSS) in patients with signet-ring cell carcinoma (SRCC) of the colon, a particularly aggressive type of colon cancer. Methods. Information on patients with SRCC of the colon with no distant metastasis was extracted from the US Surveillance, Epidemiology, and End Results (SEER) database. An X-tile plot was used to determine the optimal cutoff age at diagnosis. Results. A total of 776 patients were included in data analysis. The X-tile program revealed an optimal cutoff at 35 years of age. A higher percentage of stage III disease and a higher percentage of N2 disease were observed in patients ≤ 35 years of age. The multivariate Cox proportional model demonstrated that patients ≤ 35 years of age were more likely to have a poorer survival outcome compared with patients aged >35 years (HR 1.411, 95% CI 1.032–1.929, and P = 0.031). Conclusion. In contrast to the association of younger age with better survival in colon cancer patients, younger age (≤35 years) is associated with poorer survival outcome in patients with SRCC of the colon without distant metastasis.

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The Characteristics and Prognostic Effect of E-Cadherin Expression in Colorectal Signet Ring Cell Carcinoma

Cited by 28 publications

References 36 publications

Characteristics and prognostic factors of colorectal mucinous adenocarcinoma with signet ring cells

Characteristics and prognostic factors of colorectal mucinous adenocarcinoma with signet ring cells

Clinical Significance of CLDN18.2 Expression in Diffuse-Type Metastatic Gastric Cancer

Younger Age Is Associated with Poorer Survival in Patients with Signet-Ring Cell Carcinoma of the Colon without Distant Metastasis

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