The Characteristics and Patterns of Drug-Resistant Pulmonary Tuberculosis in Eastern India

Giri, Vishal Prakash; Giri, Om Prakash; Pandey, Pooja Tripathi; Mishra, Kripa Nath; Prasad, Ravi Shanker; Lal, Prabhat Kumar; Pratap, R; Nishant, Nikhil; Sufian, Abu; Ahmad, Reyaz; Kanodia, Shubhra

doi:10.3390/tropicalmed7090244

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Patients with drug-resistant TB are more likely to have adverse treatment outcomes. [ 1 , 52 , 57 , 58 ] While we found a lower prevalence of DR-TB in the OA, our findings point to the importance of identifying these patients given their higher odds of treatment failure.…”

Section: Discussionmentioning

confidence: 46%

Tuberculosis presentation and outcomes in older Hispanic adults from Tamaulipas, Mexico

Medrano,

Lee,

Gemeinhardt

et al. 2023

Medicine

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Older people are at high risk of developing and dying from pulmonary infections like tuberculosis (TB), but there are few studies among them, particularly in Hispanics. To address these gaps, we sought to identify host factors associated with TB and adverse treatment outcomes in older Hispanics by conducting a cross-sectional study of TB surveillance data from Tamaulipas, Mexico (2006–2013; n = 8381). Multivariable logistic regressions were assessed for older adults (OA ≥65 years) when compared to young (YA, 18–39 years) and middle-aged adults (40–64 years). We found that the OA had features associated with a less complicated TB (e.g., lower prevalence of extra-pulmonary TB and less likely to abandon treatment or have drug resistant TB), and yet, were more likely to die during TB treatment (adj-OR 3.9, 95% 2.5, 5.25). Among the OA, excess alcohol use and low body mass index increased their odds of death during TB treatment, while a higher number of reported contacts (social support) was protective. Diabetes was not associated with adverse outcomes in OA. Although older age is a predictor of death during TB disease, OA are not prioritized by the World Health Organization for latent TB infection screening and treatment during contact investigations. With safer, short-course latent TB infection treatment available, we propose the inclusion of OA as a high-risk group in latent TB management guidelines.

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Section: Discussionmentioning

confidence: 46%

Tuberculosis presentation and outcomes in older Hispanic adults from Tamaulipas, Mexico

Medrano,

Lee,

Gemeinhardt

et al. 2023

Medicine

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show abstract

“…Patients with drug-resistant TB are more likely to have adverse treatment outcomes [1,49,54,55]. While we found a lower prevalence of DR-TB in the ELD, our findings point to the importance of identifying these patients given their higher odds of treatment failure.…”

Section: Discussionmentioning

confidence: 52%

Tuberculosis presentation and outcomes in elderly Hispanics from Tamaulipas, Mexico

Medrano¹,

Lee²,

Gemeinhardt

et al. 2023

Preprint

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Old people are at high risk of developing and dying from pulmonary infections like tuberculosis (TB), but they are few studies among them, and particularly in Hispanics. To address these gaps, we sought to identify host factors associated with TB and adverse treatment outcomes in old Hispanics by conducting a secondary analysis of TB surveillance data from Tamaulipas, Mexico (2006-2013; n=8,381). Multivariable logistic regressions were assessed for the elderly (ELD, ≥65 years) when compared to young (YA, 18 to 39 years) and middle-aged adults (MAA, 40 to 64 years). We found that the ELD had features associated with a less complicated TB (e.g. less extra-pulmonary TB, abandoning of treatment or having drug resistant TB), and yet, were more likely to die (adj-OR 3.9, 95% 2.5, 5.25). Among the elderly, excess alcohol use and low BMI increased their odds of death, while diabetes and BCG vaccination were protective. These data suggest that old people share some, but not all the risk factors for adverse TB treatment outcomes, when compared with YA or MAA. Furthermore, even though old age in itself is an important predictor of death during TB, old people are not prioritized by the World Health Organization for latent TB infection screening and treatment during contact investigations. We propose the inclusion of the elderly as a high-risk group in TB management guidelines.

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Multi-therapeutic potential of flavonoids as an essential component in nutraceuticals for the treatment and management of human diseases

Okoduwa,

Abdulwaliyu,

Igiri

et al. 2024

Phytomedicine Plus

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The Characteristics and Patterns of Drug-Resistant Pulmonary Tuberculosis in Eastern India

Cited by 3 publications

References 16 publications

Tuberculosis presentation and outcomes in older Hispanic adults from Tamaulipas, Mexico

Tuberculosis presentation and outcomes in older Hispanic adults from Tamaulipas, Mexico

Tuberculosis presentation and outcomes in elderly Hispanics from Tamaulipas, Mexico

Multi-therapeutic potential of flavonoids as an essential component in nutraceuticals for the treatment and management of human diseases

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