The characteristics and improved intestinal permeability of vancomycin PLGA-nanoparticles as colloidal drug delivery system

Zakeri–Milani, Parvin; Loveymi, Badir Delf; Jelvehgari, Mitra; Valizadeh, Hadi

doi:10.1016/j.colsurfb.2012.10.021

Cited by 110 publications

(70 citation statements)

References 45 publications

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“…The -biodegradable natural polymers already used for the preparation of nanoparticulate DDSs include poly(L-glutamic acid) (PGA) produced by Bacillus subtilis [37], pullulan produced from starch by the fungus Aureobasidium pullulans [33], gelatin [6], alginate [9,33], chitosan [15] and its derivatives including N-palmitoyl chitosan [14] or mannosemodified trimethyl chitosan-cysteine (MTC) conjugate [20] and many others [19]. Intriguingly, the widespread application of PLGA results from its relatively inert composition, stable rate of degradation and known degradation products [22], namely lactic acid and glycolic acid [23]. PLGA-based nanoparticles are characterized by good mechanical stability and narrow size distribution [38].…”

Section: Classification and Properties Of Polymeric Nanoparticlesmentioning

confidence: 99%

“…PLGA-based nanoparticles are characterized by good mechanical stability and narrow size distribution [38]. This polymer, used as a matrix during nanoparticulate carrier preparation, can protect the drugs from enzymatic degradation [27] after oral administration [23]. More relevantly, it has been reported that the drug release rate can be controlled by the PLGA molecular weight as well as by the glycolide to lactide ratio [23].…”

Section: Classification and Properties Of Polymeric Nanoparticlesmentioning

confidence: 99%

“…This polymer, used as a matrix during nanoparticulate carrier preparation, can protect the drugs from enzymatic degradation [27] after oral administration [23]. More relevantly, it has been reported that the drug release rate can be controlled by the PLGA molecular weight as well as by the glycolide to lactide ratio [23]. Polymerbased nanoparticles are also promising candidates for non-invasive transdermal delivery without removing the stratum corneum [30].…”

Section: Classification and Properties Of Polymeric Nanoparticlesmentioning

confidence: 99%

“…Polymer-based nanoparticles can be used as the carrier for numerous biologically active molecules including drugs [18], proteins [7], monoclonal antibodies [13], nucleic acids [19,20], biological extracts [16,21] and others [22]. This review will be especially concerned with the application of polymer-based nanoparticles for the treatment of various disease entities including bacterial [23,24], fungal [25] and parasitic [26] infections, ulcers [11], hypertension [12], angina [8], glaucoma [9], uveitis [27], asthma [22], cancer [15,28], neurodegenerative disease [29] and many others [30,31]. It deserves to be emphasized that several polymers are characterized by satisfying biocompatibility and predictable biodegradability [9,22] while others are non-degradable or undergo slow degradation [22,32].…”

mentioning

confidence: 99%

“…It deserves to be emphasized that several polymers are characterized by satisfying biocompatibility and predictable biodegradability [9,22] while others are non-degradable or undergo slow degradation [22,32]. Remarkably, polymer-based nanoparticles can be administered orally [20,23], intravenously [18], percutaneously [30], ophthalmically [27], pulmonarily [12,25], transmucosally to nose and lungs [33] or delivered to the brain via inner ear administration [16]. It is noteworthy that selected polymers are approved by the Food and Drug Administration (FDA) to be used for therapeutic applications [27].…”

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confidence: 99%

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Recent Developments in Application of Polymeric Nanoparticles as Drug Carriers

Moritz¹,

Geszke-Moritz²

2015

Adv Clin Exp Med

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Nanotechnology is an interdisciplinary field of science offering interesting solutions for many branches of human life. Nanomaterials, defined as structures with at least one dimension below 100 nm, are the focus of increasing research attention as versatile tools for nanomedicine. Among the various nanostructures recently described in the literature, polymeric nanoparticles, characterized by satisfying biocompatibility, have aroused great interest as the carriers for various biologically active substances such as drugs, proteins and nucleic acids. These nanoparticles have already been reported as efficient vehicles for therapeutic agents in many disease entities. They can be delivered to the body via different administration routes. This review addresses recent advances in the usage of polymeric nanoparticles as drug carriers described in the years 2013 and 2014. The advantages of polymeric nanocarriers for medical application are highlighted, including their low toxicity, evaluated in vitro and in vivo. Moreover, the classification of polymeric nanoparticles is presented as well as various protocols of their synthesis (Adv Clin Exp Med 2015, 24, 5, 749-758).

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Section: Classification and Properties Of Polymeric Nanoparticlesmentioning

confidence: 99%

Section: Classification and Properties Of Polymeric Nanoparticlesmentioning

confidence: 99%

Section: Classification and Properties Of Polymeric Nanoparticlesmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Recent Developments in Application of Polymeric Nanoparticles as Drug Carriers

Moritz¹,

Geszke-Moritz²

2015

Adv Clin Exp Med

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PLGA nano‐ and microparticles for the controlled release of florfenicol: Experimental and theoretical study

Karp

Busatto

Turino

et al. 2018

J of Applied Polymer Sci

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In this study, PLGA particle systems were studied for the controlled release of florfenicol, a broad spectrum antibiotic used in veterinary treatments. The emulsion-solvent evaporation technique was used for particle preparation. To evaluate the particle size, entrapment efficiency, and drug release behavior, factors such as solvent type, emulsification time and methods, and drug to polymer ratio were investigated. The results showed that the use of ethyl acetate and 2.5 min of ultrasonication or 30 min of homogenization can lead to sub-micron and micron-sized particles, respectively. Sizes between 200-300 nm and 2-3 μm were obtained for ultrasonication and homogenization procedures, respectively. Entrapment efficiencies were around 20% for all systems and release profiles were size dependent. In addition, a mathematical model was implemented to simulate the florfenicol transport. The model predicts the florfenicol release and takes into account the particle size, polymer molecular weight, and autocatalytic polymer degradation. Simulation results are in good agreement with experimental results.

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Gellan gum spongy‐like hydrogel‐based dual antibiotic therapy for infected diabetic wounds

Mendes

Fraga

Peixoto

et al. 2023

Bioengineering & Transla Med

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Diabetic foot infection (DFI) is an important cause of morbidity and mortality. Antibiotics are fundamental for treating DFI, although bacterial biofilm formation and associated pathophysiology can reduce their effectiveness. Additionally, antibiotics are often associated with adverse reactions. Hence, improved antibiotic therapies are required for safer and effective DFI management. On this regard, drug delivery systems (DDSs) constitute a promising strategy. We propose a gellan gum (GG)‐based spongy‐like hydrogel as a topical and controlled DDS of vancomycin and clindamycin, for an improved dual antibiotic therapy against methicillin‐resistant Staphylococcus aureus (MRSA) in DFI. The developed DDS presents suitable features for topical application, while promoting the controlled release of both antibiotics, resulting in a significant reduction of in vitro antibiotic‐associated cytotoxicity without compromising antibacterial activity. The therapeutic potential of this DDS was further corroborated in vivo, in a diabetic mouse model of MRSA‐infected wounds. A single DDS administration allowed a significant bacterial burden reduction in a short period of time, without exacerbating host inflammatory response. Taken together, these results suggest that the proposed DDS represents a promising strategy for the topical treatment of DFI, potentially overcoming limitations associated with systemic antibiotic administration and minimizing the frequency of administration.

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The characteristics and improved intestinal permeability of vancomycin PLGA-nanoparticles as colloidal drug delivery system

Cited by 110 publications

References 45 publications

Recent Developments in Application of Polymeric Nanoparticles as Drug Carriers

Recent Developments in Application of Polymeric Nanoparticles as Drug Carriers

PLGA nano‐ and microparticles for the controlled release of florfenicol: Experimental and theoretical study

Gellan gum spongy‐like hydrogel‐based dual antibiotic therapy for infected diabetic wounds

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