The characteristics and antioxidation of Oudemansiella radicata selenium polysaccharides on lipopolysaccharide-induced endo-toxemic mice

Gao, Zheng; Zhang, Chen; Liu, Hui; Zhu, Yongfa; Ren, Zhenzhen; Jing, Huijuan; Li, Shangshang; Zhang, Jianjun; Liu, Xingtian; Liu, Jia

doi:10.1016/j.ijbiomac.2018.05.078

Cited by 25 publications

(17 citation statements)

References 58 publications

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“…In the case of SPs, the molecular weight can be determined with high-performance gel permeation (or gel filtration) chromatography [ 149 , 156 , 227 , 228 , 229 ], and the presence and quantification of Se can be confirmed by ICP-OES, ICP-MC, or AAS [ 149 , 182 , 229 ]. More in-depth characterization can be obtained with Fourier-transform infrared spectroscopy (FTIR), UV spectroscopy, and AFM [ 156 ].…”

Section: Analytical Methods For Selenium Detection and Speciationmentioning

confidence: 99%

Selenium Analysis and Speciation in Dietary Supplements Based on Next-Generation Selenium Ingredients

Constantinescu-Aruxandei

Frîncu

Capră

et al. 2018

Nutrients

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Selenium is essential for humans and the deficit of Se requires supplementation. In addition to traditional forms such as Se salts, amino acids, or selenium-enriched yeast supplements, next-generation selenium supplements, with lower risk for excess supplementation, are emerging. These are based on selenium forms with lower toxicity, higher bioavailability, and controlled release, such as zerovalent selenium nanoparticles (SeNPs) and selenized polysaccharides (SPs). This article aims to focus on the existing analytical systems for the next-generation Se dietary supplement, providing, at the same time, an overview of the analytical methods available for the traditional forms. The next-generation dietary supplements are evaluated in comparison with the conventional/traditional ones, as well as the analysis and speciation methods that are suitable to reveal which Se forms and species are present in a dietary supplement. Knowledge gaps and further research potential in this field are highlighted. The review indicates that the methods of analysis of next-generation selenium supplements should include a step related to chemical species separation. Such a step would allow a proper characterization of the selenium forms/species, including molecular mass/dimension, and substantiates the marketing claims related to the main advantages of these new selenium ingredients.

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Section: Analytical Methods For Selenium Detection and Speciationmentioning

confidence: 99%

Selenium Analysis and Speciation in Dietary Supplements Based on Next-Generation Selenium Ingredients

Constantinescu-Aruxandei

Frîncu

Capră

et al. 2018

Nutrients

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“…Briey, RAW264.7 cells with a density of 1 Â 10 5 cells per well were cultured in 96-well plates at 37 C for 24 h. Then, the cells were pre-treated with WPSPP-1 at different concentrations (100, 200, 400 and 800 mg mL À1 ) and 1 mg mL À1 of LPS, and the cells were then incubated at 37 C for another 24 h. The supernatant was collected and the levels of inammatory mediator (NO) and cytokines (TNF-a, IL-1b, IL-6 and IL-10) were determined according to the instructions of commercial ELISA kits. 12,24 2.5. In vivo anti-inammatory activity of WPSPP-1 2.5.1.…”

Section: In Vitro Anti-inammatory Activity Of Wpspp-1mentioning

confidence: 99%

“…Taken together, strengthening the antioxidant capacity against ROS and inhibiting the expression of pro-inammatory cytokines are both critical for the treatment of LPS-induced inammation. 11,12 The gastrointestinal tract of mammals inhabit a dynamic and complex microbial community comprising the intestinal ora. 13 The relationship of reciprocal symbiosis between microora and the host is key to maintain the homeostatic balance of intestinal microbiota.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory activity of a water-soluble polysaccharide from the roots of purple sweet potato

et al. 2020

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“…It is synonymous with Xerula radicata (Relhan) Doerfelt or Oudemansiella radicata (Relhan) Singer, which is commonly known as the 'deep root mushroom' or the 'rooting shank' [1]. Previous studies have reported that this type of mushroom contains polysaccharides and primary metabolites, which exhibited useful pharmacological effects, including antioxidant, antiaging, immunomodulatory, antitumor, and antibacterial activities [2][3][4][5]. One of the most interesting molecules identified in a culture of this mushroom was oudenone, which was shown to have an inhibitory effect on tyrosine hydroxylase [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…In this study, we used these various collected mushrooms to perform an extensive chemical analysis of the fruiting bodies of X. furfuracea. The column chromatographic separation of its MeOH extract and the subsequent high-performance liquid chromatography (HPLC) purification led to the isolation of five ergosterol derivatives (1)(2)(3)(4)(5), as shown via liquid chromatography/mass spectrometry (LC/MS)-based analysis. Their structures were elucidated by combining both the spectroscopic data and the results of the LC/MS analysis.…”

Section: Introductionmentioning

confidence: 99%

Ergostane-Type Steroids from Korean Wild MushroomXerula furfuraceathat Control Adipocyte and Osteoblast Differentiation

Lee

Choi²,

Ryoo

et al. 2020

J. Microbiol. Biotechnol.

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As part of our current work to discover structurally and/or biologically novel compounds from Korean wild mushrooms, we isolated five ergostane-type steroids (1-5) from the fruiting bodies of Xerula furfuracea via repeated column chromatographic separations and HPLC purification. The chemical structures of the isolated steroids were shown to be (22E,24R)-24-methylcholesta-4,22diene-3,6-dione (1), ergosta-7,22-diene-3β,5α,6β-triol (2), ergosta-7,22-diene-3β,5α,6β,9α-tetraol (3), (22E,24R)-5α,8α-epidioxyergosta-6,22-diene-3β-ol-3-O-β-D-glucopyranoside (4), and (22E,24R)-5α,8α-epidioxyergosta-6,9,22-triene-3β-ol-3-O-β-D-glucopyranoside (5) based on comparison of the data regarding their spectroscopic and physical properties with those of previous studies. Notably, this is the first report on the presence of the identified steroids (1-5) in this mushroom. We tested compounds 1-5 to determine their effects on adipogenesis and osteogenesis in the mouse mesenchymal stem cell line C3H10T1/2 and found that compounds 4 and 5 suppressed the differentiation of stem cells into adipocytes. Notably, in addition to its suppressive effect on adipogenesis, compound 5 was also shown to promote the osteogenic differentiation of stem cells. These findings demonstrate that the bioactive compounds isolated might be effective for the treatment of menopause-associated syndromes, such as osteoporosis and obesity, as the isolated compounds were shown to suppress adipogenesis and/or promote osteogenesis of stem cells.

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The characteristics and antioxidation of Oudemansiella radicata selenium polysaccharides on lipopolysaccharide-induced endo-toxemic mice

Cited by 25 publications

References 58 publications

Selenium Analysis and Speciation in Dietary Supplements Based on Next-Generation Selenium Ingredients

Selenium Analysis and Speciation in Dietary Supplements Based on Next-Generation Selenium Ingredients

Anti-inflammatory activity of a water-soluble polysaccharide from the roots of purple sweet potato

Ergostane-Type Steroids from Korean Wild MushroomXerula furfuraceathat Control Adipocyte and Osteoblast Differentiation

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