The characteristic large‐scale annual analysis by gender and age in heart failure patients: cohort for 10 years in Korea

Abstract

AimsThe prevalence and incidence rate of heart failure (HF) continues to increase along with the aging of the population and the increase of ischaemic heart disease. The morbidity and mortality of HF are also on the rise in the industrialized countries; it can be a great public health problem. A detailed and accurate analysis of the demographical incidence and prevalence of HF is an important first step in predicting the occurrence of the disease in the future and proper preparing for prevention. Here, we aimed to analyse the annual prevalence and incidence of HF by gender and age using long‐term national health insurance service data in the Republic of Korea.Methods and resultsA total of 47 243 patients newly diagnosed with HF between 2006 and 2015 among nationally representative random subjects of 1 000 000 were included. The data of age and gender were analysed by year, and the total population information of the Ministry of Land, Infrastructure, and Transport of Korea was referred to compare the data of HF patients with the total population (2008–15). Over the decade from 2006 to 2015, the prevalence of HF patients showed tendency of increase (P < 0.001). The overall incidence rate was also gradually increasing (P < 0.001), but in women, it tended to decrease gradually. Women significantly accounted higher than the male group in incidence of HF over the period (54.6% vs. 45.4%, P < 0.001). The mean age at the time of diagnosis gradually increased (P = 0.002 for total, P = 0.001 for each gender). Total incidence was highest in 70s (27.22%), but males were the most in their 60s and females were in their 70s. Analysis of annual trend by age and gender distribution of HF incidence in men presented highest in the 50s–70s with a similar pattern annually, and the incidence is increasing more recently. Different from that of men, in the case of women, the incidence gradually increased with age in a similar annual pattern, peaking in their 70s and gradually decreasing in recent years.ConclusionsThe prevalence and incidence of HF are gradually increasing. It increased rapidly in their 50s and older. It showed an increased incidence of HF especially in men between their 50s and 70s, and more observation and caution for the management of the risk factors may be needed to prevent HF in the male group.

Identification and validation of aging-related genes in heart failure based on multiple machine learning algorithms

“…In fact, among the elderly, maintaining normal circulatory function helps increase disease-free life expectancy and maintain a higher quality of life ( 27 ). As the aging of the population increases and the survival rate of ischemic cardiomyopathy increases, heart failure in the elderly population has brought serious economic and public health burdens ( 28 ). Although the common mechanisms of heart failure and aging are an active research topic, current research focus is still on investigating the potential anti-aging mechanisms of heart failure therapeutic drugs, and the aging-related mechanisms and potential therapeutic drugs for heart failure remain unclear ( 29 ).…”

Identification and validation of aging-related genes in heart failure based on multiple machine learning algorithms

“…In fact, among the elderly, maintaining normal circulatory function helps increase disease-free life expectancy and maintain a higher quality of life 22 . As the aging of the population increases and the survival rate of ischemic cardiomyopathy increases, heart failure in the elderly population has brought serious economic and public health burdens 23 . Although the common mechanisms of heart failure and aging are an active research topic, current research focus is still on investigating the potential anti-aging mechanisms of heart failure therapeutic drugs, and the aging-related mechanisms and potential therapeutic drugs for heart failure remain unclear 24 .…”

Editors' highlight picks from 2023 in ESC heart failure

“…The accumulation of these risk factors was associated with a graded higher risk of HF 2 . Similarly in Korea, the prevalence and incidence of HF are gradually increasing, especially in men between their 50s and 70s: More concern regarding the management of the risk factors may be needed to prevent HF, particularly in the male group 3 …”