The characterisation and risk factors of ischaemic heart disease in patients with coeliac disease

Abstract

SUMMARY BackgroundStudies have shown an increased risk of ischaemic heart disease (IHD) in patients with coeliac disease (CD), despite the patients' lack of traditional IHD risk factors.

Assessment of Endothelial Dysfunction With Adhesion Molecules in Patients With Celiac Disease

“…In a recent study, Emilsson et al (23) reported that patients with CD and ischemic heart disease had lower levels of classical risk factors such as obesity, smoking, and cholesterol, but systemic inflammation associated with CD could have a causative role in the increase of comorbid cardiovascular diseases seen in CD patients.…”

Commentary: coeliac disease and atherosclerosis - hand in hand?

“…In addition, our findings are in accordance with observations in other different immune disorders. 4 As a diagnosis of CD is becoming increasingly common in the general population, we share the point of Dr Ludvigsson that cardiovascular risk pattern in CD patients needs to be thoroughly addressed. As a matter of fact, we are developing a large prospective trial to test our results and any suggestion from referral academic centres is highly appreciated.…”

“…3,4 They conclude that young adults with coeliac disease are at increased risk of higher mean LDL cholesterol, have a thicker carotid intima media thickness (IMT), while their endothelium-dependent dilatation is decreased -all bad for cardiovascular health. Interestingly, the authors also found that dietary treatment influenced C-reactive protein levels, and that both IMT and endothelium-dependent dilatation improved with diet.…”

Obesity, Metabolic Syndrome, and Cardiac Risk Factors: Going Gluten-Free, for Better or Worse?

“…Celiac disease has been linked to a slightly increased risk of cardiovascular disease [1]. Several studies have reported increased blood pressure but lower body mass index (BMI), improved cholesterol profiles, and fewer smokers in individuals with celiac disease [2,3]. Mucosal healing in celiac disease is not associated with a decreased risk of myocardial infarction, stroke, or atrial fibrillation when compared to celiac individuals with persistent villous atrophy [4].…”