In the quest for mathematical foundations of M-theory, the Hypothesis H, that fluxes are quantized in Cohomotopy theory, implies, on flat but possibly singular spacetimes, that M-brane charges locally organize into equivariant homotopy groups of spheres. Here we show how this leads to a correspondence between phenomena conjectured in M-theory and fundamental mathematical concepts/results in stable homotopy, generalized cohomology and Cobordism theory Mf :-stems of homotopy groups correspond to charges of probe p-branes near black b-branes; -stabilization within a stem is the boundary-bulk transition; -the Adams d-invariant measures G 4 -flux; -trivialization of the d-invariant corresponds to H 3 -flux; -refined Toda brackets measure H 3 -flux; -the refined Adams e-invariant sees the H 3 -charge lattice; -vanishing Adams e-invariant implies consistent global C 3 -fields; -Conner-Floyd's e-invariant is the H 3 -flux seen in the Green-Schwarz mechanism; -the Hopf invariant is the M2-brane Page charge ( G 7 -flux); -the Pontrjagin-Thom theorem associates the polarized brane worldvolumes sourcing all these charges. In particular, spontaneous K3-reductions with 24 branes are singled out from first principles:-Cobordism in the third stable stem witnesses spontaneous KK-compactification on K3-surfaces; -the order of the third stable stem implies the 24 NS5/D7-branes in M/F-theory on K3. Finally, complex-oriented cohomology emerges from Hypothesis H, connecting it to all previous proposals for brane charge quantization in the chromatic tower: K-theory, elliptic cohomology, etc.:-quaternionic orientations correspond to unit H 3 -fluxes near M2-branes; -complex orientations lift these unit H 3 -fluxes to heterotic M-theory with heterotic line bundles. In fact, we find quaternionic/complex Ravenel-orientations bounded in dimension; and we find the bound to be 10, as befits spacetime dimension 10+1. S 3 S 3 S 3 K3\(24 • D 4