The changing trends in epidemiological characteristics of gastric adenocarcinoma: a Tunisian center experience

Ghrissi, Rafik; Elghali, Mohamed Amine; Ghammam, Rim; Gouader, Amine; Hamila, Fehmi; Letaief, Rached

doi:10.18203/2349-2902.isj20151248

Cited by 1 publication

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References 32 publications

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“…The epidemiology of GC has been widely studied in Japan and in the developed western world [ 11 – 13 ], but only few reports from the developing countries have been published, especially in younger patients [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil

et al. 2018

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BackgroundIt has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare clinicopathological features between younger and older patients with GC in Northeastern Brazil.MethodsA total of 207 patients with distal GC (41 patients ≤45 years, considered younger group, and 166 > 45 years, considered older group) were evaluated prospectively during a 6 year period.ResultsThe mean patient age in the young group was 37.41 years old and 64.43 years in the older group. No significant difference was found regarding gender, area of residence, history of alcohol consumption, chronic tobacco smoking. Prevalence of first-degree GC history was 12.5% (7.3% in younger group vs. 13.9% in older; p < 0.46). The most frequent symptom was gastric pain and weight loss. Diffuse infiltrative cancer was more frequently seen in younger patients (70.70% vs. 33.70%, respectively; p < 0.01), as was histologically less differentiated tumors (63.40% vs. 33.10%; p < 0.01) and stage IV of GC (48.80% vs. 30.70%; p < 0.015). Five-year survival, evaluated in 82 patients, was lower in younger patients (p = 0.045); however, after adjusting for stage of GC in the multivariate analysis, this association did not remain significant. Family history of GC and gender had no impact on survival.ConclusionsYounger patients showed higher prevalence of diffuse type of Lauren and lower survival that was attributed to higher rate of advanced stage of GC. Gastric cancer screening strategies should also be considered in younger individuals, especially in areas of high prevalence. Further studies are warranted to determine risk factors associated with gastric cancer in young adults.

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Section: Introductionmentioning

confidence: 99%