The changing survival profile of people with Down's syndrome: implications for genetic counselling

Glasson, Emma; Sullivan, Sheena G.; Hussain, Rafat; Petterson, Beverly; Montgomery, Philip; Bittles, Alan H.

doi:10.1034/j.1399-0004.2002.620506.x

Cited by 349 publications

(271 citation statements)

References 27 publications

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“…[7][8][9][10][11][12] At each age, the average survival from the six studies was used as the survival curve above 10 years of age. This was assumed to apply regardless of the year of birth.…”

Section: Live Birth Prevalence Of Down's Syndromementioning

confidence: 99%

The population prevalence of Down’s syndrome in England and Wales in 2011

Morris

2013

Eur J Hum Genet

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There is uncertainty over the population prevalence of people with Down's syndrome in England and Wales. This study aimed to estimate the population prevalence of Down's syndrome in England and Wales in 2011. A meta-analysis of published survival rates of people with Down's syndrome from 1938 to 2010 was conducted and the results were applied to the estimated numbers of babies born with Down's syndrome since 1938 in England and Wales. An estimated 37 090 people had Down's syndrome in England and Wales in 2011, a population prevalence of 0.66 per 1000 people; 650 under 1, 2673 aged 1-5, 7115 aged 5-18, 12 819 aged 19-40, 10 626 aged 41-55 and 3207 aged 56 and older. The average life expectancy for babies with Down's syndrome born in 2011 was 51 years and the median life expectancy was 58 years. This study provides clarity on the number of people with Down's syndrome in England and Wales. Owing to sudden increases in the survival of babies with Down's syndrome in the 1950s there are a large proportion of people with Down's syndrome who are in their 40s. These people have an increased risk of developing dementia in the future and services should be aware of their potential needs.

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Section: Live Birth Prevalence Of Down's Syndromementioning

confidence: 99%

The population prevalence of Down’s syndrome in England and Wales in 2011

Morris

2013

Eur J Hum Genet

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“…The median age at death has increased to nearly 60 years, with some people with DS living into their 70s [1,2]. Premature aging has been noted in this population; the rate of primary aging is nearly twice that of adults with typical development (TD) [3].…”

Section: Introductionmentioning

confidence: 99%

“…Follow-up ANOVAs revealed significant group differences for all variables except absolute and dimensionless stride frequency. Inspection of the means (See Table 2) revealed adults with DS walked slower with shorter, wider strides while spending more time in both stance and double support (speed F [1,22] …”

Section: Over-ground Walking Characteristicsmentioning

confidence: 99%

Early onset of stabilizing strategies for gait and obstacles: Older adults with Down syndrome

Smith

Ulrich

2008

Gait & Posture

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Our goal was to examine the gait patterns of older adults with Down syndrome (DS) for precocious stabilizing adaptations during comfortable over-ground walking and in more challenging conditions. Twelve participants with DS and 12 with typical development (TD) were matched for height, weight and age (range 35 to 62 years). We used a 6-camera motion capture system to assess foot trajectories over obstacles. Participants first walked at their preferred speed over a 5.3 m instrumented gait mat (unperturbed condition). Subsequent walking trials included perturbations mid-walkway: a) minimal obstacle to step over (12 cm high), b) moderate obstacle to step onto with both feet and then off (standard step), c) maximum obstacle to step onto with only one foot and over with the other (standard step).Adults with DS walked slower with shorter, wider strides while spending more time in both stance and double support. These adaptations increased during the moderate and maximal perturbations. They stepped with the minimal perturbation obstacle further forward in their crossing step and produced a lower, flatter trajectory of the lead foot, with less dorsiflexion at crossing. This strategy decreased trailing toe clearance but did not alter leading heel clearance.The combined effects of ligamentous laxity, low tone, obesity, inactivity and physiological decrements associated with aging lead to these stability-enhancing adaptations at a younger chronological age in adults with DS. We believe intervention to increase overall stability will be beneficial in helping adults with DS maintain optimal functional mobility and health.

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“…El mismo estudio colaborativo reporta que Chile es el país con mayor tasa de nacimiento de niños con esta condición en la Región 2 . Por otra parte, la sobrevida de las personas con SD ha aumentado en forma sorprendente en las últimas décadas, teniendo en la década de los 40 una expectativa de vida de 9 años, la que llega en la actualidad a cerca de 60 años 3,4 .…”

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