The changing spectrum of disease, etiology, and diagnosis of mucormycosis

Marchevsky, Alberto M.; Bottone, Edward J.; Geller, Stephen A.; Giger, D K

doi:10.1016/s0046-8177(80)80054-2

Cited by 135 publications

(65 citation statements)

References 8 publications

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“…The dismal rate of premortem diagnosis in the pa-tients reviewed contrasts sharply with the improved rate of diagnosis noted in recent years by Parfrey [2] and by Marchevsky et al [1]. This lack of early diagnosis in the patients presented in this review probably reflects the fact that the association of mucormycosis with either aluminum or iron overload treated with deferoxamine has only very recently been noted.…”

Section: Commentscontrasting

confidence: 56%

“…The organisms most commonly implicated in clinical disease belong to the genera Mucor, Rhizopus, Absidia, and Cunninghamella [18]. Although wound infections with these organisms may occur in healthy individuals [19], invasive infection almost always occurs in patients with underlying diseases, especially acute leukemias and poorly controlled diabetes meMtus [1,2]. Rhinocerebral and pulmonary forms of the disease are the most common presentations of invasive infection, but widespread dissemination may also occur [1,2].…”

Section: Commentsmentioning

confidence: 99%

“…Since the mid-1970s, the prognosis of mucormycosis has improved markedly [1,2]. Therapy is based on early surgical debridement, amphotericin B administration, and stabilization of any underlying disease process [2,20].…”

Section: Commentsmentioning

confidence: 99%

“…ucormycosis is an uncommon acute and often fatal opportunistic fungal infection that usually occurs in patients with poorly controlled diabetes mellitus, acute leukemias, or other immunosuppressive conditions [1,2]. A new association, that of mucormycosis occurring in patients receiving deferoxamine therapy for iron or aluminum excess, has been reported with increasing frequency since 1986 [3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”

mentioning

confidence: 99%

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Mucormycosis: association with deferoxamine therapy

Daly

Velázquez

Bradley

et al. 1989

The American Journal of Medicine

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Section: Commentscontrasting

confidence: 56%

Section: Commentsmentioning

confidence: 99%

Section: Commentsmentioning

confidence: 99%

mentioning

confidence: 99%

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Mucormycosis: association with deferoxamine therapy

Daly

Velázquez

Bradley

et al. 1989

The American Journal of Medicine

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“…18 . 19 .The agents of mucormycosis are ubiquitous in nature, where they live on decaying organic material as saprophytes. They may be isolated from the air, soil, fruits, clinical materials and human orifices 4 .…”

mentioning

confidence: 99%

Subcutaneous mucormycosis caused by Rhizopus oryzae: probable nosocomial acquired infection

Filho¹,

Coelho

Porto

et al. 1985

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe Authors present a case of subcutaneous mucormycosis occurring in a patient with clinical and biochemical evidence of diabetic ketoacidosis. The clinical, mycological and histopathological features are described, emphasizing the relevance of a rapid diagnosis in order to stablish early treatment. The clinical forms of mucormycosis and the main associated conditions are briefly reviewed as well as the most probable conditions which may lead to the enhanced susceptibility to infection in the diabetic patient in ketoacidosis. The recovery of Rhizo¬ pus oryzae from the air of the room of the patient suggests a nosocomial infection acquired through contamination of venous puncture site by air borne spores. INTRODUCTIONThe human infections caused by fungi of the class Zygomycetes are cosmopolitan and have been reported in normal and immunocompromised hosts. The disease has been generically called Zygomycosis (Phycomycosis). GREER 12 suggested the terms Mucormycosis and Entomophtoromycosis to name the infections restrictly caused by Zygomycetes of the orders Mucorales and Entomophtorales, since they are different diseases 12 . The human mucormycosis is world-wide in distribution often as an opportunistic infection and rarely affecting immunologicaly normal individuals 18 . Frequently it is a disease of acute evolution, characterized by invasion and growth of Mucorales in the vascular wall and lumen, with subsequent mycotic thromboembolism, ischemia, tissue necrosis and eventually death depending on the effected site. The rhinocerebral variant is the most acute and fulminant of the known mycosis 21 .22. The entomophtoromycosis, also known as subcutaneous zygomycosis or basidiobolomycosis is restricted to tropical and subtropical regions, being reported the cases mainly from Africa and Asia, and occasionally from South America 5 . 13 . 18 . Generally it has a chronic evolution characterized by the development of eosinophilic granuloma in the subcutaneous fat, rhino-orbital cavities and other areas of the organism, with swelling of the affected regions. The patients are apparently healthy 6 . 18 . 19 .The agents of mucormycosis are ubiquitous in nature, where they live on decaying organic material as saprophytes. They may be isolated from the air, soil, fruits, clinical materials and human orifices 4 . They reproduce by sexual and asexual ways and in the anamorphic (asexual) state form a great amount of spores inside sacular structures called sporangia. The principal way of dissemination is the air. The primary or exogenous cutaneous and subcutaneous mucormycosis is a rare occurrence and the way of infection is related to the rupture of the skin barrier with subsequent development of necrotic lesions in the skin or subcutaneous iat i5 . 2i .Recently microepidemics of cutaneous mucormycosis were reported in hospitals and were related to the use of elasticized adhesive tape dressings on open wounds in immunocompromised patients 1U3 as well in patients with orthopedic problems and whithout apparent immunological c...

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Bronchopleural Fistula Followed by Massive Fatal Hemoptysis in a Patient With Pulmonary Mucormycosis

Watts¹

1983

Arch Intern Med

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The changing spectrum of disease, etiology, and diagnosis of mucormycosis

Cited by 135 publications

References 8 publications

Mucormycosis: association with deferoxamine therapy

Mucormycosis: association with deferoxamine therapy

Subcutaneous mucormycosis caused by Rhizopus oryzae: probable nosocomial acquired infection

Bronchopleural Fistula Followed by Massive Fatal Hemoptysis in a Patient With Pulmonary Mucormycosis

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