The changing profile of infantile tremor syndrome in hilly terrain of India

Singla, Deeksha; Sharma, Milap; Sharma, Seema; Sharma, Vipin

doi:10.4103/0976-3147.165344

Cited by 4 publications

(2 citation statements)

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“…All patients were born normally with average birth weight, as observed by Singla et al ., in their case series. [ 16 ] Interestingly, we observed that ITS was more common in higher birth order, which could be related to poor maternal nutrition after the first childbirth. No such observation is there in the literature.…”

Section: Discussionmentioning

confidence: 89%

Infantile tremor syndrome in modern times

et al. 2017

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Background:Infantile tremor syndrome (ITS) is a clinical syndrome of acute or gradual onset of mental and psychomotor changes, pigmentary disturbances of hair and skin, pallor, and tremors in malnourished children aged between 5 months and 3 years. It is a well-known entity, but the exact etiopathogenesis is still not known.Setting and Design:Prospective observational study carried out in the Department of Pediatrics at Dr RPGMC Tanda, Kangra in Himachal Pradesh.Materials and Methods:Demographic, clinical, and laboratory profile of 25 children with the diagnosis of preinfantile and ITS was collected who were admitted from May 2014 to June 2015.Statistical Analysis:Descriptive analysis was performed using SPSS 17 trial version.Results:These children accounted for 0.5% of total pediatric admissions. Median, standard deviation age was 10, 3.1 months. Male to female ratio was 1.27:1. Cases were present throughout the year with two peaks observed in the months of May and November. This disease was found to be more common in higher birth order (68%). Complementary feeding, that too improper, was initiated in only 4 cases (16%). Ninety-six percent cases presented with comorbid illnesses. Respiratory tract infection was the most common association, followed by urinary tract infection. There was moderate anemia with dimorphic picture (40%). Thirteen (52%) had vitamin B12 levels below normal. Magnesium levels, though statistically insignificant (P = 0.8) were lower in patients with tremors.Conclusion:This is a disease of multi-micronutrient deficiency, which can be present either alone or in association. Educating women about proper nutrition during pregnancy and timely administration of complementary feeding is of utmost importance.

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Section: Discussionmentioning

confidence: 89%

Infantile tremor syndrome in modern times

et al. 2017

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“…Empirical antibiotic therapy is typically used in the early stages of sepsis since it is hard to immediately get the findings of a bacterial culture. However, the administration of antibiotics can result in drug overuse and antibiotic resistance (Singla et al, 2015). Dexamethasone is an adrenocortical hormone that is frequently used to treat sepsis and has good anti-inflammatory, anti-allergic, and anti-toxic effects.…”

Section: Introductionmentioning

confidence: 99%

Activation of SIRT1 signaling pathway by clove improves cognitive dysfunction in septic mice

et al. 2022

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Clove is a kind of food spice, which can be used as food flavoring additive. In this work, we looked at clove's impact and underlying mechanism on cognitive impairment in infected mice. By using the open field test, Morris water maze, ELISA technique, kit method, and qPCR method, the biochemical and molecular biological indices of mice were identified. Clove component composition was established using HPLC. The findings demonstrated that clove might enhance mouse survival rates in comparison to the model group and could also lengthen driving distances, standing and combing periods, target quadrant duration, and crossing periods. In the hippocampus of infected mice, clove can lower levels of TNF-α, IL-6, IL-1β, and MDA while increasing SOD and CAT activity. In the hippocampus of infected animals, clove additionally increased the mRNA expression of SIRT1 and FOXO1 and decreased the mRNA expression of NF-B and p53. Animal studies revealed that clove's impact was comparable to dexamethasone in that it might help septic mice with cognitive impairment. The analysis revealed that rutin, isoquercitrin, ferulic acid, dihydroquercetin, and quercitrin were all present in clove. It is clear that clove can help septic mice with cognitive impairment by triggering SIRT1 through its active components.

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