The changing patterns of uveitis in a tertiary institute of Northeast India

Das, Dipankar; Bhattacharjee, Harsha; Das, Kalyan Kumar; Tahiliani, Prerana; Bhattacharyya, Pankaj; Bharali, Gayatri; Das, Manik Chandra; Deka, Apurba; Paul, Rajashree

doi:10.4103/0301-4738.170973

Cited by 22 publications

(24 citation statements)

References 8 publications

(29 reference statements)

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“…[ 4 ] They have also shown that diagnosis of herpetic uveitis (HSV, VZV, and CMV) and Fuchs' uveitis syndrome was on the rise when compared to their 2005 study. [ 5 ] A similar finding is also reported by Dogra et al . and they attribute the increased incidence of the viral disease may be attributed to high clinical suspicion, based on classic signs (iris changes/high intraocular pressure) and the recent availability of PCR-based diagnosis.…”

supporting

confidence: 87%

Changing patterns in uveitis South India: Comparison between two decades

Balasundaram

2018

Indian J Ophthalmol

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supporting

confidence: 87%

Changing patterns in uveitis South India: Comparison between two decades

Balasundaram

2018

Indian J Ophthalmol

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“…[ 7 ] Changing pattern of any disease in a subset of the population is an important health indicator. [ 8 ] There are lots of similar reports from different parts of India and world. [ 1 3 4 5 8 9 10 ] The necessities of these reports are to increase the awareness of regional variation in disease configuration which is an important health predictor in the epidemiological study.…”

Section: Discussionmentioning

confidence: 99%

Changing uveitis patterns in South India - Comparison between two decades

Biswas

Sitaula

Multani

2018

Indian J Ophthalmol

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Purpose:Changing pattern of uveitis in a subset of a population is an important ocular health indicator.Methods:A comparative study was done between uveitis patients of 2013 and 1995 using two proportions Z-test.Results:In 2013, 352 new uveitis cases were examined. Males 56%, females 44%; unilateral 30.4%; bilateral in 69.6%. A specific diagnosis achieved in 66.2%. Anterior uveitis was seen in 35.22%, intermediate uveitis in 30.11%, posterior uveitis in 25%, and panuveitis in 9.65%. There was no significant difference in the incidence of new uveitic cases (1.04% vs. 1.8%). A decline in male preponderance from 64% to 56% (P = 0.0187) was observed. In both studies, anterior uveitis was the most common but human leukocyte antigen-B27 positivity uveitis had increased (29.83% vs. 14.5%; P < 0.05). Intermediate uveitis was the second-most common type instead of posterior uveitis (P = 0.0006). In posterior uveitis cases, etiology was established in 88.6% versus 56.06% cases (P < 0.05). The most common cause of posterior uveitis was tuberculosis (TB) (35.2%). Viral retinitis had increased to 6.81% from 0.76% (P < 0.05). However, a declining trend in cases of toxoplasmosis was observed (P = 0.0545). The cause of panuveitis was comparable in both studies. The prevalence of TB has significantly increased in the present era (22.5% vs. 0.64%; P < 0.0001) and was the proven etiological cause of uveitis in overall 22.5% of which 4.8% cases were of anterior uveitis cases, 7.1% cases of intermediate uveitis cases, 8.8% cases of posterior uveitis cases, and 1.8% of panuveitis cases.Conclusion:A shifting paradigm of uveitis over the past two decades was observed.

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“…1 Tuberculosis (TB) has historically been considered a major cause of uveitis, but the importance of TB as a primary cause of uveitis has gradually decreased in the last decades, although it has recently re-emerged. [2][3][4] TB is an infectious disease caused by Mycobacterium tuberculosis. One-third of the world's population is thought to be infected with M. tuberculosis and in 2015, 10.4 million new infections occured.…”

Section: Introductionmentioning

confidence: 99%

Tuberculosis and other causes of uveitis in Indonesia

Nora

Sitompul

Bakker

et al. 2017

Eye

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PurposeThe purpose of this study is to assess the causes of uveitis in Indonesia and determine the importance of tuberculosis (TB) as a cause of uveitis.Patients and methodsProspective cohort study examining 146 consecutive new human immunodeficiency virus-negative patients with active uveitis between June 2014 and May 2015. We assessed the anatomic locations and specific causes of uveitis, as well as associations with infectious and non-infectious systemic diseases. We determined the prevalence of positive QuantiFERON Tb Gold test (QFT) results in Indonesian patients with uveitis and calculated the number of patients with active systemic TB.ResultsPosterior and panuveitis were the most common anatomic entities (38% each). Infections represented the most frequent cause of uveitis (33%); the most prevalent were toxoplasmosis (19%) and active systemic TB (8%). The majority of patients were QFT positive (61%). A specific diagnosis could not be established in 45% of the patients. At first presentation to the ophthalmologist, the majority of patients (66%) had a visual acuity of less than finger counting at 3 m and already exhibited various complications of uveitis. When classifying the QFT-positive patients with unexplained uveitis into a TB-related group, the percentage of 'TB-associated' uveitis cases increased from 8-48%. Highly elevated QFT levels were observed in patients with uveitis of unknown cause and no signs of active systemic TB.ConclusionsIn Indonesia, infectious uveitis was the most common type of uveitis and the leading causes consisted of toxoplasmosis and TB. The association observed between highly elevated QFT results and uveitis of otherwise unexplained origins indicates that a link exists between the latent TB infection and the development of uveitis.

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The changing patterns of uveitis in a tertiary institute of Northeast India

Cited by 22 publications

References 8 publications

Changing patterns in uveitis South India: Comparison between two decades

Changing patterns in uveitis South India: Comparison between two decades

Changing uveitis patterns in South India - Comparison between two decades

Tuberculosis and other causes of uveitis in Indonesia

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