“…Research has most commonly reported of a large group of individuals with a high probability of alcohol or cocaine use disorder (Hedden et al, 2010;Schwartz et al, 2010), and this group represents the vast majority of treatment seekers in the Spanish context (EMCDDA, 2019). The presence of classes characterized by cocaine as primary substance, cannabis as secondary, and additional alcohol/other drugs use (class 4) and by alcohol as primary and cannabis as secondary substance (class 5) is also in line with previous studies (Bailey et al, 2019;Chan et al, 2020;Hedden et al, 2010;Timko et al, 2017). Last, individuals with heroin as primary substance, cocaine as secondary and additional alcohol use (class 6) represent a subpopulation, which, considering the current low prevalence of heroin use in Spain (Plan Nacional Sobre Drogas, 2019), may be related to the so-called heroin epidemic that happened during the 1980s (Sánchez-Niubò et al, 2009), but may also be of interest to other countries in light of the upward trend of heroin use and overdose in the United States and Europe (NIDA, 2018b).…”