The changing pattern of hepatitis A in Lebanese adults

Melhem, Nada M.; Jaffa, Miran A.; Zaatari, Mohamad; Awada, Hanane; Salibi, Noura El; Ramia, S.

doi:10.1016/j.ijid.2014.10.007

Cited by 16 publications

(18 citation statements)

References 23 publications

(26 reference statements)

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“…The seroprevalence of hepatitis A in Istanbul, Turkey Marmara Medical Journal 2017; 30: [14][15][16][17] have resulted in reduction in the rate of childhood exposure in some countries [2]. Since, most infections, especially in children, are subclinical, we can estimate HAV infection prevalence in a population by determination of the anti-HAV antibodies [4].…”

Section: Introductionmentioning

confidence: 99%

The seroprevalence of hepatitis A in Istanbul, Turkey

Karadeniz¹,

Alasehir²,

Yeşilbağ³

et al. 2017

Marmara Medical Journal

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Dünya genelinde akut viral hepatitin önde gelen nedenlerinden olan ve enterik yolla bulaşan hepatit A infeksiyonu, gelişmekte olan ülkelerde değişim göstermiştir. Bu çalışmanın amacı İstanbul, Türkiye'de farklı yaş gruplarında hepatit A virusu (HAV) seroprevalansının güncel durumunu belirlemektir.Gereçler ve Yöntemler: Ocak 2011 ve Aralık 2013 yılları arasında 3,868 hastaya ait serum örneklerinde anti-HAV IgG değerleri mikropartikül enzim immunoassey (MPEIA) yöntemi (Architect SR i1000 and i2000, Abbott Diagnostics, Germany) ile retrospektif olarak değerlendirilmiştir.Bulgular: Çalışmada, tüm hastalarda total anti-HAV antikor prevalansı %64,8 olarak saptanmıştır. Değerlendirilen 3,868 serumun %54'ü erkek ve %46'sı kadın hastalardan elde edilmiştir. Yaşlara göre seropozitiflik oranları; 0-16 yaş arasında %55, 17-30 yaş arasında %47, 31-45 yaş arasında %73,5 olarak belirlenmiştir. 0-30 yaş arasında %50 (972/1944) olan seroprevalans oranı; 46 yaş üzerindeki grupta %89 oranı ile anlamlı artış ortaya koymaktadır.Sonuç: Genç yaş grubundaki seropozitiflik oranlarının düşük olması, bu grubu HAV infeksiyonu açısından daha riskli kılmaktadır. Sonuçlar, çocukların ve seronegatif genç yetişkinlerin HAV'e karşı rutin olarak aşılanmasını desteklemektedir.

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Section: Introductionmentioning

confidence: 99%

The seroprevalence of hepatitis A in Istanbul, Turkey

Karadeniz¹,

Alasehir²,

Yeşilbağ³

et al. 2017

Marmara Medical Journal

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“…In developing countries, poor sanitary and hygienic conditions, low economic status, high crowding and inadequate water treatment contribute to a high endemicity pattern; the majority of children acquires infection (most often asymptomatic) during early childhood [ 11 , 12 ]. Thus, in these countries overt forms of hepatitis A are relatively rare and severe forms are exceptional [ 13 , 14 ]. The epidemiologic pattern of hepatitis A infection is currently changing in many developing countries where socio-economic conditions are improving: hepatitis A affects the population at a later age, leading to an increased risk of symptomatic and more severe forms of disease that typically occur in adulthood [ 15 - 18 ].…”

Section: Introductionmentioning

confidence: 99%

Migration pattern of hepatitis A virus genotype IA in North-Central Tunisia

Béji-Hamza

Taffon

Mhalla

et al. 2015

Virol J

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Background: Hepatitis A virus (HAV) epidemiology in Tunisia has changed from high to intermediate endemicity in the last decades. However, several outbreaks continue to occur. The last reported sequences from Tunisian HAV strains date back to 2006. In order to provide an updated overview of the strains currently circulating in Tunisia, a large-scale molecular analysis of samples from hepatitis A cases was performed, the first in Tunisia. A Tunisian genotype IA sequence dataset, including both the 78 newly obtained IA sequences and 51 sequences retrieved from GenBank, was used for phylogenetic investigation, including analysis of migration pattern among six towns. Virus gene flow from Sfax and Monastir was directed to all other towns; in contrast, the gene flows from Sousse, Tunis, Mahdia and Kairouan were directed to three, two, one and no towns, respectively. Conclusions: Several different HAV strains co-circulate in Tunisia, but the predominant genotype still continues to be IA (78/81, 96% isolates). A complex gene flow (migration) of HAV genotype IA was observed, with Sfax and Monastir showing gene flows to all other investigated towns. This approach coupled to a wider sampling can prove useful to investigate the factors underlying the spread of HAV in Tunisia and, thus, to implement appropriate preventing measures.

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“…The changes in the Korean endemicity of hepatitis A are likely a good example for developing countries, as hepatitis A is exhibiting a transition from high endemicity to intermediate endemicity in several Asian countries (e.g., China, India, and Malaysia) and Middle Eastern countries (e.g., Iran, Iraq, the United Arab Emirates, and Lebanon) [25-27]. Furthermore, hepatitis A in the Middle East may spread rapidly, given the poor hygiene, unclean water, and dense populations in Syrian refugee camps [27].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, hepatitis A in the Middle East may spread rapidly, given the poor hygiene, unclean water, and dense populations in Syrian refugee camps [27]. Moreover, hepatitis A vaccination is not currently sufficient in the Middle East, despite hepatitis A vaccination being included in several national immunization programs (e.g., in Bahrain, Cyprus, Iraq, Israel, Saudi Arabia, and Qatar) [27]. Therefore, since Korea has undergone rapid economic development, the patterns of change for hepatitis A in Korea may help predict future patterns in these countries.…”

Section: Discussionmentioning

confidence: 99%

Age-period-cohort analysis of hepatitis A incidence rates in Korea from 2002 to 2012

Seo

Choi

et al. 2016

Epidemiol Health

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OBJECTIVESThis study aimed to evaluate the epidemiology of hepatitis A in Korea from 2002 to 2012 using age-period-cohort analyses.METHODSWe used claims data from the Korean National Health Insurance Corporation for the entire population. Census data from 2010 were used as the standard population. The incidence of hepatitis A was assumed to have a Poisson distribution, and the models and effects were evaluated using the intrinsic estimator method, the likelihood ratio, and the Akaike information criterion.RESULTSThe incidence of hepatitis A gradually increased until 2007 (from 17.55 to 35.72 per 100,000 population) and peaked in 2009 (177.47 per 100,000 population). The highest incidence was observed among 27-29-year-old individuals when we omitted data from 2005 to 2007. From 2005 to 2007, the peak incidence was observed among 24-26-year-old individuals, followed by 27-29-year-olds. The best model fits were observed when the age-period-cohort variables were all considered at the same time for males, females, and the whole population.CONCLUSIONSThe incidence of hepatitis A exhibited significant age-period-cohort effects; its incidence peaked in 2009 and was especially high among Koreans 20-39 years of age. These epidemiological patterns may help predict when high incidence rates of hepatitis A may occur in developing countries during their socioeconomic development.

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The changing pattern of hepatitis A in Lebanese adults

Abstract: Our seroprevalence data reveal that young adults are becoming more at risk of acquiring HAV infection. Thus the introduction of hepatitis A vaccine is highly recommended.

Cited by 16 publications

References 23 publications

The seroprevalence of hepatitis A in Istanbul, Turkey

The seroprevalence of hepatitis A in Istanbul, Turkey

Migration pattern of hepatitis A virus genotype IA in North-Central Tunisia

Age-period-cohort analysis of hepatitis A incidence rates in Korea from 2002 to 2012

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