The changing pattern of fusobacterium infections in humans: recent experience with fusobacterium bacteraemia

Épaulard, Olivier; Brion, Jean‐Paul; Stahl, J.-P.; Colombe, B.; Maurin, Max

doi:10.1111/j.1469-0691.2005.01328.x

Cited by 28 publications

(19 citation statements)

References 10 publications

(11 reference statements)

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“…However, in the current review, a total of 21 patients were found to have F. necrophorum bacteremia following a throat infection but with no intracranial or metastatic infection. Three of these patients had deep neck infection; one had a peritonsillar abscess (313), and two had parapharyngeal abscesses (130,227). Six cases had proven internal jugular vein thrombophlebitis.…”

Section: Natural History and Forms Of F Necrophorum Septicemiamentioning

confidence: 99%

“…Epaulard et al (130) reported that among 6,274 bacteremias over a 5-year period at one institution, 26 (0.4%) were adult cases of Fusobacterium sp. bacteremia.…”

Section: Anaerobic Bacteremiamentioning

confidence: 99%

“…Cutaneous pustules and subcutaneous abscesses have been reported in 0 to 3% of cases ( (130,288), and two had necrotic or embolic skin lesions (269,312). A Fusobacterium sp.…”

Section: Natural History and Forms Of F Necrophorum Septicemiamentioning

confidence: 99%

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Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

2007

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SUMMARYSummary:Human infection withFusobacterium necrophorumusually involvesF. necrophorumsubsp.funduliformerather thanF. necrophorumsubsp.necrophorum, which is a common pathogen in animals. Lemierre's syndrome, or postanginal sepsis, is the most common life-threatening manifestation. Tonsillitis is followed by septic thrombophlebitis of the internal jugular vein and then a septicemia with septic emboli in lungs and other sites. Recent evidence suggests thatF. necrophorumcan be limited to the throat and cause persistent or recurrent tonsillitis.F. necrophorumis unique among non-spore-forming anaerobes, first for its virulence and association with Lemierre's syndrome as a monomicrobial infection and second because it seems probable that it is an exogenously acquired infection. The source of infection is unclear; suggestions include acquisition from animals or human-to-human transmission. Approximately 10% of published cases are associated with infectious mononucleosis, which may facilitate invasion. Recent work suggests that underlying thrombophilia may predispose to internal jugular vein thrombophlebitis. Lemierre's syndrome was relatively common in the preantibiotic era but seemed to virtually disappear with widespread use of antibiotics for upper respiratory tract infection. In the last 15 years there has been a rise in incidence, possibly related to restriction in antibiotic use for sore throat.

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Section: Natural History and Forms Of F Necrophorum Septicemiamentioning

confidence: 99%

“…Epaulard et al (130) reported that among 6,274 bacteremias over a 5-year period at one institution, 26 (0.4%) were adult cases of Fusobacterium sp. bacteremia.…”

Section: Anaerobic Bacteremiamentioning

confidence: 99%

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Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

2007

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“…A high degree of suspicion is needed and usually the syndrome is not diagnosed until microbiology results are available 1017. With suspected clinical picture imaging modalities usually confirm the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…The organism is usually isolated from blood cultures. Other microbiological specimens include synovial fluid, skin pustules and pus from liver abscesses, empyema and a bronchoscopic aspirate 1017…”

Section: Discussionmentioning

confidence: 99%

A case of Lemierre syndrome

Alherabi

2009

Annals of Saudi Medicine

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Minimum requirements for a rapid and reliable routine identification and antibiogram of Fusobacterium necrophorum

Jensen

Kristensen

Nielsen

et al. 2008

Eur J Clin Microbiol Infect Dis

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Three hundred fifty-seven isolates of Fusobacterium necrophorum from human infections in Denmark were consecutively collected over a 3 year period for the purpose of establishing the minimum requirements for rapid and reliable routine identification of Fusobacterium necrophorum using phenotypic characters. The first 40 isolates were fully characterized by the most common phenotypic tests mentioned in the literature, while the last 317 where identified solely by the established minimum requirements for rapid and reliable routine identification of Fusobacterium necrophorum. All but one isolate were identical in all phenotypic tests. The outlying strain differed in morphology and the ability to agglutinate erythrocytes. On the basis of our findings it should be possible within 3-4 days to identify and differentiate F. necrophorum from other species including other Fusobacterium spp. by the unique but subspecies specific colony morphology, susceptibility to kanamycin and metronidazole, the smell of butyric acid, chartreuse colour fluorescence, and beta-haemolysis on horse blood agar. Three-hundred fifty-six isolates were identified as F. necrophorum subsp. funduliforme while one strain was F. necrophorum subsp. necrophorum. The species and subspecies level was confirmed for the first 40 isolates by real-time PCR. MIC in mg/l was determined for the 40 isolates. MIC(90) was 0.047 for penicillin, 0.047 for clindamycin, 0.25 for metronidazole, 0.38 for cefuroxime, >32 for imipenem, 0.012 for meropenem, and 2 for erythromycin. All 357 isolates were susceptible to penicillin and metronidazole indicating that these antibiotics are still the drugs of choice in antibiotic therapy of F. necrophorum infections, but therapy with clindamycin may be an alternative. Erythromycin should be avoided.

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The changing pattern of fusobacterium infections in humans: recent experience with fusobacterium bacteraemia

Cited by 28 publications

References 10 publications

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

Human Infection withFusobacterium necrophorum(Necrobacillosis), with a Focus on Lemierre's Syndrome

A case of Lemierre syndrome

Minimum requirements for a rapid and reliable routine identification and antibiogram of Fusobacterium necrophorum

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