2013
DOI: 10.1055/s-0032-1333468
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The Changing Landscape of Diagnostic Services for Tuberculosis

Abstract: During the last decade there has been a dramatic change in the laboratory approach to tuberculosis (TB) diagnosis in the developing world. This change began with the realization that acid-fast bacillus smear microscopy alone was totally inadequate to deal with the dual problems of human immunodeficiency virus (HIV)-associated TB and drug-resistant TB that threaten to undermine global progress in TB control. Subsequently, increased financial resources for TB laboratory services and the establishment of a system… Show more

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Cited by 28 publications
(13 citation statements)
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“…Moreover, for accurate drug therapy it is important to detect mutations so that physicians can choose a potent drug against the particular MTB-DR strain [10,11]. Therefore, a diagnostic tool which is rapid, accurate, highly sensitive, and field-deployable, is essential for the timely detection of the drug resistant strains and selection of drugs for the treatment [12].…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, for accurate drug therapy it is important to detect mutations so that physicians can choose a potent drug against the particular MTB-DR strain [10,11]. Therefore, a diagnostic tool which is rapid, accurate, highly sensitive, and field-deployable, is essential for the timely detection of the drug resistant strains and selection of drugs for the treatment [12].…”
Section: Introductionmentioning
confidence: 99%
“…This change began with the realization that acid-fast bacillus smear microscopy alone was totally inadequate to deal with the problems of HIV associated TB and drugresistant TB. [1] Direct smear examination with Ziehl-Neelsen (ZN) staining for the diagnosis of TB as employed but its low sensitivity is a major drawback. Major advances in molecular techniques, which rapidly identify Mycobacterium (deoxyribonucleic acid) DNA in sputa, may overcome these obstacles.…”
Section: Introductionmentioning
confidence: 99%
“…The limitation of the TB expansion is thus based on the improvement and generalization of diagnostic methods [5] and early antibiotic therapy. The WHO recommends the following combined therapy employing first-line antibiotics: rifampicin (or rifabutin), isoniazid, pyrazinamide and ethambutol for two months followed by rifampicin and isoniazid for four months [6].…”
Section: Introductionmentioning
confidence: 99%