The changing incidence of Kaposi's sarcoma among patients with AIDS

Haverkos, Harry W.; Friedman‐Kien, Alvin E.; Drotman, D. Peter; Morgan, W. Meade

doi:10.1016/0190-9622(90)70170-m

Cited by 38 publications

(13 citation statements)

References 15 publications

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“…Early in the onset of the AIDS epidemic, several groups began to report on the high frequency of Kaposi's sarcoma in immunocompromised patients (Pape et al, 1983;Haverkos and Drotman, 1985). The incidence of Kaposi's sarcoma among men with AIDS decreased from 40% in 1981 to 20% in 1992, but still remains the most common AIDS-associated cancer in the United States (Biggar and Rabkin, 1996).…”

Section: Clinical and Experimental Support For Tumour Immunosurveillancementioning

confidence: 99%

A critical analysis of the tumour immunosurveillance controversy for 3-MCA-induced sarcomas

Schreiber

Podack

2009

Br J Cancer

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The cancer immunoediting hypothesis has gained significant footing over the past decade as a result of work performed using sarcomas induced by 3-methylcholanthrene (3-MCA) in mice. Despite the progress made by several groups in establishing evidence for the three phases of immunoediting (elimination, equilibrium and escape), there continues to be active controversy on the nature of interaction between spontaneously formed tumour cells and the immune system during the early phases of tumourigenesis. At the root of this controversy is conflicting and unresolved evidence spanning back to the 1970s regarding the incidence and frequency of 3-MCA-induced sarcomas in immunocompetent mice as compared to immunodeficient mice. In this mini review we provide a critical analysis of both sides of this controversy.

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Section: Clinical and Experimental Support For Tumour Immunosurveillancementioning

confidence: 99%

A critical analysis of the tumour immunosurveillance controversy for 3-MCA-induced sarcomas

Schreiber

Podack

2009

Br J Cancer

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“…AIDS-associated KS (AIDS-KS) is the most frequent tumor of HIV-l infected homo-bisexual men and is the most aggressive form of KS [21]; African KS (AKS) is frequent in certain areas of Africa, where it can represent up to 10% of the total tumors and acquires a very aggressive course after HIV-1 infection [117]; classical KS (CKS) occurs in elderly men of the Eastern-Mediterranean area and is a milder form of the disease [118]; post-transplant KS (PKS) occurs in transplanted individual after therapy with cyclosporin and corticosteroids [119]. Although these forms have a different geographical distribution and clinical course they share many common features including (i) a disturbance of the immune system characterized initially by immunoactivation particularly of CD8 T cells with Th1-type cytokine production and later, at least for AIDS-KS and PKS, by immunosuppression; (ii) histopathology of the lesions; (iii) high levels of the same inflammatory cytokines, angiogenic molecules and growth factors in the lesions; and (iv) infection by human herpesvirus-8 (HHV-8).…”

Section: Kaposi's Sarcomamentioning

confidence: 99%

“…Tumors appear multifocally and are characterized by endothelial cell activation and proliferation, as well as by inflammatory infiltrate, particularly in early stages. In progressed stages, the so-called KS spindle cells, which are regarded as the tumor cells of KS, dominate the histological picture [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Interactions between endothelial cells and HIV-1

Bussolino

Mitola

Serini

et al. 2001

The International Journal of Biochemistry &Amp; Cell Biology

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Endothelial cells (EC) participate in inflammatory and immune reactions by producing and responding to soluble mediators. Human immunodeficiency virus (HIV)-1 profoundly alters the features of EC. In some anatomical districts, they are infected by the virus and may represent a relevant reservoir. During lymphomononuclear cell diapedesis, EC activate virus replication in crossing cells. Direct or indirect damage of EC is particularly relevant in central nervous system, where blood-brain barrier perturbation is pivotal in neuronal degeneration. The observed alterations of EC adhesive properties contribute in altered leukocyte traffic from blood to lymphoid organs and tissues and play a role in the onset of immune surveillance alteration. These alterations of EC functions are relevant for the general vasculopathy, which marks the acquired immunodeficiency syndrome, and in particular are instrumental in the pathogenesis of Kaposi's sarcoma. Here we discuss the biological and molecular activation of EC in HIV-1 infection that represents the basis to understand the pathogenesis of HIV-1 associated vascular diseases.

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“…Kaposi's sarcoma (KS)' is an angioproliferative disease which in recent years has become epidemic in association with HIV-1 infection (AIDS-KS) (1)(2)(3)(4). Characteristic histological fea-media; ECGF, endothelial cell growth factor; H-UVE, human umbilical vein-derived endothelial; KS, Kaposi's sarcoma.…”

Section: Introductionmentioning

confidence: 99%

“…tures of KS include the proliferation of spindle-shaped cells (KS cells) of vascular origin considered to be the "tumor" cells of KS, and of normal endothelial cells forming blood vessels (angiogenesis), inflammatory cell infiltration, and edema ( [1][2][3][4][5] ). Previous observations suggested that, at least in early stages, KS is not a real tumor but a cytokine-mediated hyperplastic/proliferative disease with angiogenic factors playing a key role in its development (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor. A novel strategy for the therapy of KS.

Ensoli

Markham²,

Kao³

et al. 1994

J. Clin. Invest.

120

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Kaposi's sarcoma (KS) is the most frequent tumor of HIV-1-infected individuals (AIDS-KS). Typical features of KS are proliferating spindle-shaped cells, considered to be the tumor cells of KS, and endothelial cells forming blood vessels. Basic fibroblast growth factor (bFGF), a potent angiogenic factor, is highly expressed by KS spindle cells in vivo and after injection in nude mice it induces vascular lesions closely resembling early KS in humans. Similar lesions are induced by inoculating nude mice with cultured spindle cells from AIDS-KS lesions (AIDS-KS cells) which produce and release bFGF. Here we show that phosphorothioate antisense (AS) oligonucleotides directed against bFGF mRNA (ASbFGF) inhibit both the growth of AIDS-KS cells derived from different patients and the angiogenic activity associated with these cells, including the induction of KS-like lesions in nude mice. These effects are due to the block of the production of bFGF which is required by AIDS-KS cells to enter the cell cycle and which, after release, mediates angiogenesis. The effects of ASbFGF are specific, dose dependent, achieved at low (0.1-1 ,uM), nontoxic, oligomer concentrations, and are reversed by the addition of bFGF to the cells, suggesting that ASbFGF oligomers are promising drug candidates for KS therapy. (J. Clin. Invest. 1994.

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The changing incidence of Kaposi's sarcoma among patients with AIDS

Cited by 38 publications

References 15 publications

A critical analysis of the tumour immunosurveillance controversy for 3-MCA-induced sarcomas

A critical analysis of the tumour immunosurveillance controversy for 3-MCA-induced sarcomas

Interactions between endothelial cells and HIV-1

Block of AIDS-Kaposi's sarcoma (KS) cell growth, angiogenesis, and lesion formation in nude mice by antisense oligonucleotide targeting basic fibroblast growth factor. A novel strategy for the therapy of KS.

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