The changing incidence of human papillomavirus-associated oropharyngeal cancer using multiple imputation from 2000 to 2010 at a Comprehensive Cancer Centre

Habbous, Steven; Chu, Karen; Qiu, Xin; Delfa, Anthony La; Harland, Luke; Fadhel, Ehab; Hui, Angela Bik‐Yu; Perez-Ordonez, Bayardo; Weinreb, Ilan; Liu, Feifei; Waldron, John; O’Sullivan, Brian; Goldstein, David P.; Xu, Wei; Liu, Geoffrey

doi:10.1016/j.canep.2013.09.011

Cited by 45 publications

(65 citation statements)

References 43 publications

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“…Methionine oxidation was specified as a variable modification. For protein inference minimization, an in-house 2 The Cancer Genome Atlas, accepted for publication.…”

Section: Methodsmentioning

confidence: 99%

“…In the Western world, the overall decline in the incidence of head and neck squamous cell carcinoma (HNSCC) 1 has been accompanied by an increase in oropharyngeal carcinoma (OPC), the most common HNSCC subtype (1,2). This trend has been attributed to a concomitant decline in smoking and increase in oral human papillomavirus (HPV) infection rates (2).…”

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confidence: 99%

“…This trend has been attributed to a concomitant decline in smoking and increase in oral human papillomavirus (HPV) infection rates (2). HPV has been reported to be associated with more than 60% of all OPCs in North America, with HPV16 being the predominant high-risk strain in HNSCC (2)(3)(4)(5).…”

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confidence: 99%

“…In parallel, the efforts of the Cancer Genome Atlas (TCGA) have produced broad genomic characterization of ϳ300 head and neck cancer (HNC) specimens, including OPCs, highlighting potential genomic alterations responsible for cancer initiation and progression. 2 What is currently missing is an integration of TCGA genomic alterations with indepth proteomic analyses (17). Because proteins and their functions are the ultimate mediators of biological activity, such integrative efforts could highlight important biological regulatory mechanisms unlikely to be discovered otherwise (17)(18)(19)(20).…”

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confidence: 99%

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Integrated Omic Analysis of Oropharyngeal Carcinomas Reveals Human Papillomavirus (HPV)–dependent Regulation of the Activator Protein 1 (AP-1) Pathway

Sepiashvili

Hui

Shi

et al. 2014

Molecular & Cellular Proteomics

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a HPV-positive oropharyngeal carcinoma (OPC) patients have superior outcomes relative to HPV-negative patients, but the underlying mechanisms remain poorly understood. We conducted a proteomic investigation of HPV-positive (n ‫؍‬ 27) and HPV-negative (n ‫؍‬ 26) formalinfixed paraffin-embedded OPC biopsies to acquire insights into the biological pathways that correlate with clinical behavior. Among the 2,633 proteins identified, 174 were differentially abundant. These were enriched for proteins related to cell cycle, DNA replication, apoptosis, and immune response. The differential abundances of cortactin and methylthioadenosine phosphorylase were validated by immunohistochemistry in an independent cohort of 29 OPC samples (p ‫؍‬ 0.023 and p ‫؍‬ 0.009, respectively). An additional 1,124 proteins were independently corroborated through comparison to a published proteomic dataset of OPC. Furthermore, utilizing the Cancer Genome Atlas, we conducted an integrated investigation of OPC, attributing mechanisms underlying differential protein abundances to alterations in mutation, copy number, methylation, and mRNA profiles. A key finding of this integration was the identification of elevated cortactin oncoprotein levels in HPV-negative OPCs. These proteins might contribute to reduced survival in these patients via their established role in radiation resistance. Through interrogation of Cancer Genome Atlas data, we demonstrated that activation of the ␤1-integrin/FAK/cortactin/

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“…Methionine oxidation was specified as a variable modification. For protein inference minimization, an in-house 2 The Cancer Genome Atlas, accepted for publication.…”

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Integrated Omic Analysis of Oropharyngeal Carcinomas Reveals Human Papillomavirus (HPV)–dependent Regulation of the Activator Protein 1 (AP-1) Pathway

Sepiashvili

Hui

Shi

et al. 2014

Molecular & Cellular Proteomics

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“…We developed a single prospective, electronic database with an associated data dictionary, based on an existing database, 1 to allow all centres to capture information uniformly. We reviewed electronic medical records and data from institutional registries to obtain clinical and demographic characteristics: age at diagnosis, sex, marital status, body mass index, year of diagnosis, anatomic subsite, clinical staging, primary treatment, smoking status and alcohol consumption (as defined previously 1 ).…”

Section: Data Collectionmentioning

confidence: 99%

Human papillomavirus in oropharyngeal cancer in Canada: analysis of 5 comprehensive cancer centres using multiple imputation

Habbous

Chu

Lau

et al. 2017

CMAJ

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A cost‐effectiveness analysis of human papillomavirus vaccination of boys for the prevention of oropharyngeal cancer

Graham

Isaranuwatchai

Habbous

et al. 2015

Cancer

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BACKGROUND: Many western countries have established female human papillomavirus (HPV) vaccination programs for the prevention of cervical cancer. The quadrivalent HPV vaccine (HPV4) has proven efficacy against additional HPV-related disease in both sexes, but the cost effectiveness of male HPV vaccination remains controversial. To assess the cost effectiveness of male HPV vaccination in Canada with respect to oropharyngeal cancer (OPC), the authors performed a preliminary cost-effectiveness analysis. METHODS: After an extensive literature review regarding HPV-related OPC in Canadian males, health care costs and clinical effectiveness estimates were obtained. A Markov model was used to compare the potential costs and effectiveness of HPV4 versus no vaccination among boys aged 12 years. A theoretical cohort based on a Canadian population of 192,940 boys aged 12 years in 2012 was assumed to apply the model. A 3-month cycle length was used with a "lifetime" time horizon. The outcome of the analysis was the incremental cost per quality-adjusted life-year (QALY). Sensitivity analyses were conducted on variables, including the vaccine uptake rate and vaccine efficacy. RESULTS: Assuming 99% vaccine efficacy and 70% uptake, HPV4 produced 0.05 more QALYs and saved $145 Canadian dollars (CAD) per individual compared with no vaccine (QALYs and costs were discounted at 5% per year). Assuming 50% vaccine efficacy and 50% uptake, HPV4 produced 0.023 more QALYs and saved $42 CAD. The results indicated that HPV4 in males may potentially save between $8 and $28 million CAD for the theoretical cohort of 192,940 over its lifetime. CONCLUSIONS: On the basis of this model, HPV vaccination for boys aged 12 years may be a cost-effective strategy for the prevention of OPC in Canada. Cancer 2015;121:1785-92. V C 2015 American Cancer Society.KEYWORDS: economic issues and research/treatment, head and neck cancer, statistical methods and models, mathematical methods and models, computer methods and models. INTRODUCTIONThe quadrivalent human papillomavirus (HPV) vaccine (HPV4) prevents preinvasive lesions of the cervix, vulva, and vagina and benign HPV-associated lesions in women. [1][2][3][4][5][6] Many countries include female HPV vaccination in their national immunization programs. However, the uptake of such programs varies (Table 1). [7][8][9][10][11][12][13][14][15] Efficacy has been demonstrated for HPV4 in sexually active men with reductions in external genital lesions and anal intraepithelial neoplasia (AIN) by 77.5% to 91.7%. 16,17 However, currently, there is no direct evidence of efficacy against other HPV-related malignancies in men. In addition, studies have demonstrated potential benefits to men by optimizing female vaccination because of herd immunity. 5,[18][19][20] In western countries, the incidence of HPV-related oropharyngeal carcinoma (HPV-OPC) is increasing more rapidly among men than among women. [21][22][23][24][25] It is projected that OPC will become the most common HPV-related cancer in the United States by 2020, ...

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The changing incidence of human papillomavirus-associated oropharyngeal cancer using multiple imputation from 2000 to 2010 at a Comprehensive Cancer Centre

Cited by 45 publications

References 43 publications

Integrated Omic Analysis of Oropharyngeal Carcinomas Reveals Human Papillomavirus (HPV)–dependent Regulation of the Activator Protein 1 (AP-1) Pathway

Integrated Omic Analysis of Oropharyngeal Carcinomas Reveals Human Papillomavirus (HPV)–dependent Regulation of the Activator Protein 1 (AP-1) Pathway

Human papillomavirus in oropharyngeal cancer in Canada: analysis of 5 comprehensive cancer centres using multiple imputation

A cost‐effectiveness analysis of human papillomavirus vaccination of boys for the prevention of oropharyngeal cancer

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