The changing epidemiology of paediatric brain tumours: a review from the Hospital for Sick Children

Kaderali, Zul; Lamberti-Pasculli, Maria; Rutka, James T.

doi:10.1007/s00381-008-0771-9

Cited by 97 publications

(91 citation statements)

References 22 publications

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“…These microscopically verified series established a low prevalence of atypical teratoid/ rhabdoid tumors between 0.9% and 2.1%. [33][34][35] A similar prevalence of 1.1% was found in a multicenter, hospitalbased study of pediatric brain tumors in France. 38 However, definite conclusions on the population-based incidence can be provided only by cancer registries, in particular specialized brain tumor registries such as the Central Brain Tumor Registry of the United States 39 or projects such as Automated Childhood Cancer Information System, a European project on the incidence and survival of pediatric tumors.…”

Section: Discussionsupporting

confidence: 53%

“…By using this strategy, we found an atypical teratoid/rhabdoid tumor incidence rate of 1.38 per 1,000,000 person-years (95% confidence interval, 0.83-2.15) in children, in accordance with the low atypical teratoid/rhabdoid tumor prevalence of singlecenter studies. [33][34][35] Atypical teratoid/rhabdoid tumor is a rare CNS tumor. However, in very young children (0-2 years), we found atypical teratoid/rhabdoid tumor to be as frequent as medulloblastoma and CNS PNET (17.3%, 16.0%, and 13.3%, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…6,7,10,13,15,17,18 Only single cases have been reported in adults. [22][23][24][25][26][27][28][29][30][31][32] Several large, hospital-based series established an atypical teratoid/rhabdoid tumor prevalence of 1% to 2% among pediatric brain tumors, 8,[33][34][35] but population-based data on the incidence of atypical teratoid/rhabdoid tumors in children are not yet available. However, such data provide important insights into the burden of disease and might contribute to patient care.…”

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Incidence of atypical teratoid/rhabdoid tumors in children

Wöehrer

Slavc

Waldhoer

et al. 2010

Cancer

127

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on behalf of the Austrian Brain Tumor Registry BACKGROUND: Atypical teratoid/rhabdoid tumors are highly malignant embryonal central nervous system (CNS) tumors that were defined as an entity in 1996. As compared with other malignant CNS tumors, their biological behavior is particularly aggressive, but patients may benefit from an intensified treatment. Atypical teratoid/rhabdoid tumors display a complex histomorphology, which renders them prone to misdiagnosis. They occur predominantly in young children, with an estimated prevalence of 1% to 2% among all pediatric CNS tumors. However, populationbased data on the incidence of these tumors are not yet available. METHODS: A nation-wide survey of malignant high-grade CNS tumors (World Health Organization grade III/IV), diagnosed in children (aged birth to 14 years) from 1996 to 2006 was conducted by the Austrian Brain Tumor Registry. A central histopathology review was performed including the assessment of SMARCB1 (INI1) protein status. RESULTS: A total of 311 newly diagnosed, malignant CNS tumors were included. Atypical teratoid/rhabdoid tumors constituted the sixth most common entity (6.1%), referring to an age-standardized incidence rate of 1.38 per 1,000,000 person-years in children. Peak incidence was found in the birth to 2 years age group, where they were as common as CNS primitive neuroectodermal tumors and medulloblastomas. A total of 47.4% of atypical teratoid/rhabdoid tumors were initially diagnosed, whereas 52.6% were retrospectively detected by the central review. The 5-year survival of atypical teratoid/rhabdoid tumor patients was 39.5%, with 66.7% in the correctly diagnosed group versus 15.0% in the not recognized group (P ¼ .0469). CONCLUSIONS: Clinicians and pathologists should be aware of the high incidence of atypical teratoid/rhabdoid tumors in young children to optimize diagnostic and therapeutic management of patients with these tumors. Cancer 2010;116:5725-32. V C 2010 American Cancer Society.KEYWORDS: atypical teratoid/rhabdoid tumor, central nervous system neoplasm, childhood, epidemiology, population-based incidence, survival.Central nervous system (CNS) tumors represent >20% of all childhood malignancies (0-14 years) in developed countries 1,2 and constitute the most common cause of cancer-related death in this age group.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Incidence of atypical teratoid/rhabdoid tumors in children

Wöehrer

Slavc

Waldhoer

et al. 2010

Cancer

127

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“…In Hungary the incidence was 37.41/million between 1999 and 2008 and 43.9/million in 2009. The cause of this high incidence in Hungary is unknown (Gupta & Banerjee et al, 2004;Hauser et al, 2003;Kaderali et al, 2009;McNeil et al, 2002;Peris-Bonet et al, 2006;Pizzo & Poplack, 2011). Astrocytomas and medulloblastoma are the most frequent among childhood CNS tumours.…”

Section: Incidencementioning

confidence: 99%

Chemotherapy of Medulloblastoma in Children

Schüler¹,

Hauser²,

Garami³

2011

Brain Tumors - Current and Emerging Therapeutic Strategies

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“…Pediatric tumor types are more sensitive to chemotherapy (CT) and to adjuvant radiation therapy (RT), compared with adults, and often require high doses of craniospinal RT, due to their propensity to disseminate within the neuraxis (1). Consequently, along with the better care provided to pediatric medulloblastoma, the spectrum of side effects is broader: RT, particularly when combined with CT, brings increased risk of severe long-term after-effects involving neurologic, cognitive, as well as endocrine and metabolic functions (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma

Siviero-Miachon

Monteiro

Pires

et al. 2011

Arq Bras Endocrinol Metab

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Objective: To analyze traits of metabolic syndrome (MetS) in medulloblastoma survivors. Subjects and methods: Sixteen childhood medulloblastoma survivors aged 18.0 (4.4) years, with history of craniospinal radiation therapy (RT) were compared with nine control subjects matched by age, gender, and body mass index, according to fat distribution, metabolic and cardiovascular variables. Results: Medulloblastoma patients showed increases in waist circum ference and its relationships (all p < 0.05), and HOMA1IR (p = 0.006), which were modified by growth hormone (GH) secretion status. However, these increases were within normal range. Conclusions: Adolescent and young adult survivors of medulloblastoma showed centripetal fat deposition and decreased insulin sensitivity, associated with GH status. Pediatric brain tumor survivors following RT should be monitored for the diagnosis of MetS traits predisposing to cardiovascular disease. Arq Bras Endocrinol Metab. 2011;55(8):653-60 Keywords Medulloblastoma/therapy; medulloblastoma/drug therapy; medulloblastoma/radiotherapy; medulloblastoma/prevention and control; cardiovascular diseases; metabolic syndrome X RESUMO Objetivo: Analisar características que predispõem para síndrome metabólica (SM) em sobrevi ventes de meduloblastoma. Sujeitos e métodos: Dezesseis sobreviventes de meduloblastoma pediátrico, 18,0 (4,4) anos, história de radioterapia (RT) cranioespinhal, comparados a nove controles pareados por idade, sexo e índice de massa corporal, de acordo com distribuição de gordura, variáveis metabólicas e cardiovasculares. Resultados: Pacientes com medulo blastoma mostraram aumento da cintura e relações (todos p < 0,05) e HOMA1IR (p = 0,006), modificados pela secreção do hormônio de crescimento (GH), mas dentro dos limites de nor malidade. Conclusões: Sobreviventes adolescentes e adultos jovens de meduloblastoma apre sentaram deposição centrípeta de gordura e diminuição da sensibilidade à insulina, associados ao estado do GH. Sobreviventes de tumor cerebral pediátrico que receberam RT devem ser monitorados para diagnosticar fatores para SM predispondo à doença cardiovascular. Arq Bras Endocrinol Metab. 2011;55(8):653-60 Descritores

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The changing epidemiology of paediatric brain tumours: a review from the Hospital for Sick Children

Cited by 97 publications

References 22 publications

Incidence of atypical teratoid/rhabdoid tumors in children

Incidence of atypical teratoid/rhabdoid tumors in children

Chemotherapy of Medulloblastoma in Children

Early traits of metabolic syndrome in pediatric post-cancer survivors: outcomes in adolescents and young adults treated for childhood medulloblastoma

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