The changing clinical presentation of complete molar pregnancy

Soto-Wright, Valena; Bernstein, Marilyn R.; Goldstein, Donald P.; Berkowitz, Ross S.

doi:10.1016/0029-7844(95)00268-v

Cited by 219 publications

(139 citation statements)

References 9 publications

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“…Vaginal bleeding remained the most common presenting symptom, occurring in 94.4% of cases which is comparable with a study done in USA by Soto-Wright et al showing that 84% of cases presented with vaginal bleeding 17 . A study done by Coukos et al, revealed that 75% of patients presented with abnormal vaginal bleeding 18 .…”

Section: Discussionsupporting

confidence: 86%

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Incidence and clinical outcome of Gestational Trophoblastic diseases in a tertiary care hospital

2017

Int. J. Curr. Res. Med. Sci.

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Introduction: Gestational trophoblastic disease (GTD) consists of group of disorders having pathology of abnormal trophoblastic proliferation ranging from hydatidiform mole to gestational trophoblastic neoplasia. Based on differences in morphology, histopathology, karyotype and clinical features, hydatidiform mole can be categorized into partial and complete moles. Molar pregnancy incidence varies across countries. The incidence of molar pregnancy in Asia is 1:100-300, choriocarcinoma 1:1000-2000 of live born children. Aim: To determine the incidence, clinical outcome and management of women with gestational trophoblastic disease (GTD) at tertiary care hospital during a study period of 6 months. Materials and Methods: This is an observational descriptive study conducted over a period of 6 months. In our study, total 18 cases were diagnosed with GTD, based on ultrasound, biochemical and histological examination. Results: During study period, total patients delivered were 3610, out of which 18 cases had GTD. The overall incidence of GTD was 1/200 pregnancies, including cases of partial mole, complete mole, choriocarcinoma, and invasive mole. Highest incidence was found in extremes of age. 77.7% of cases presented in the first trimester, while 22.3% of cases presented in the second trimester. 77.7% of cases were complete mole, 11.1% were partial mole, and 11.1% were diagnosed as gestational trophoblastic neoplasm. Majority of cases (94.4%) presented with vaginal bleeding; pregnancy induced hypertension and preeclampsia was present in 16.6% of cases, 66.6% had abdominal cramps, 44.4% presented with signs of dehydration due to hyperemesis gravidarum, 22.2% had hyperthyroidism. Ultrasound was diagnostic in 95% cases, while histopathological examination was diagnostic in 100% of the cases. The incidence of GTDs in our hospital (1 in 200) is comparable to the incidence in Middle East and Far Eastern countries. Conclusion: In our study, we found a high incidence of GTD in primigravidas. Most patients who had been diagnosed with GTD on USG were in first trimester.

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Section: Discussionsupporting

confidence: 86%

“…77.7% of the cases of GTD in our study were diagnosed in first trimester which is comparable to study done in Malaysia by Aye and Karali, showing that 75% of cases of GTDs were diagnosed at first trimester 17 .…”

Section: Discussionsupporting

confidence: 85%

Incidence and clinical outcome of Gestational Trophoblastic diseases in a tertiary care hospital

2017

Int. J. Curr. Res. Med. Sci.

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“…Thus, in our study the mean gestational age at presentation was 10 + 2 weeks, and the commonest presenting complaint was vaginal bleeding. In a study comparing 74 cases of HM presenting during 1988-1993 to 106 cases presenting during [1965][1966][1967][1968][1969][1970][1971][1972][1973][1974][1975], it was shown that there has been a significant change in the clinical presentation of HM over the years; classical signs and symptoms such as excessive uterine size, anemia, pre-eclampsia, hyperthyroidism and hyperemesis far less common in the more recent cases, which present earlier 3 .…”

Section: Effect Of Gestational Agementioning

confidence: 99%

The accuracy of first trimester ultrasound in the diagnosis of hydatidiform mole

Kirk

Papageorghiou

Condous

et al. 2007

Ultrasound in Obstet & Gyne

111

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“…Conditions associated with higher HCG production, such as multiple gestation and hydatidiform mole, are associated with NVP. 18,19 Hyperemesis gravidarum is 4 to 5 times more common with multiple gestations than in singletons. Hyperemesis is also common in 8% to 23% of hydatidiform mole cases.…”

Section: The Fundamental Stimulusmentioning

confidence: 99%

Nausea and Vomiting of Pregnancy

Kouzi¹

2003

Am J Pharm Educ

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Nausea and vomiting symptoms affect 70% to 85% of pregnant women during early pregnancy. These symptoms can have a dramatic effect on a woman's family, social, and occupational functioning. Hence, nausea and vomiting of pregnancy is a medical condition that should be taken seriously by health care professionals responsible for providing care to pregnant women. This manuscript reviews the current state of knowledge concerning the etiology, underlying mechanisms, and management of nausea and vomiting associated with pregnancy. An abbreviated version of the material found in this article is presented to second year PharmD students at the University of the Pacific as part of an elective course on evidence-based complementary and alternative therapies.Keywords: nausea and vomiting, pregnancy, drug therapy, complementary and alternative therapies and the fetus. Even when the condition is not so severe, symptoms can cause considerable distress and temporary disability. 3 Nearly 50% of employed women believed their work efficiency was substantially reduced by NVP, and as many as 25% required time off from work. Almost one half of women with NVP said that it had adverse effects on their relationships with their spouse, and 55% of pregnant women with NVP felt depressed. The financial burden of severe NVP on the American health system has been estimated to be about $130 million per year, which is based on an annual average of 39,000 hospital discharges at a mean cost of $3,300 per stay. These figures do not include physician fees, loss of productivity at home or on the job, or the cost for patient treatment.

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The changing clinical presentation of complete molar pregnancy

Cited by 219 publications

References 9 publications

Incidence and clinical outcome of Gestational Trophoblastic diseases in a tertiary care hospital

Incidence and clinical outcome of Gestational Trophoblastic diseases in a tertiary care hospital

The accuracy of first trimester ultrasound in the diagnosis of hydatidiform mole

Nausea and Vomiting of Pregnancy

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