The changing Brucella ecology: novel reservoirs, new threats

Pappas, Georgios

doi:10.1016/j.ijantimicag.2010.06.013

Cited by 190 publications

(170 citation statements)

References 25 publications

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“…Brucellosis is a systemic infection that affects many organs and tissues [8]. According to the World Health Organization (WHO), Brucellosis is the most common infection in the world, and 500,000 cases are reported annually [4,9].…”

Section: Discussionmentioning

confidence: 99%

Effects of Boiling Dairy Products on Human Brucellosis

Çelebi

Balkan

2013

EAJM

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Objective: In this study, we determined the seroprevalence of Brucella in the blood of bovine and ovine animals and in the blood of the people who raise these animals to produce cheese in two rural counties that use two different methods of cheese production in Erzurum Province in Turkey. Materials and Methods:Samples are taken from 100 bovine animals, 100 ovine animals, 100 young people between the ages of 10-20 years and 100 adults between the ages of 20-60 years. The samples were tested with the Rose Bengal Plate Test (RBPT), the Serum Agglutination Test (SAT), the Coombs' Test and a micro-ELISA. Results:We found the following rates of Brucella in the province that makes cheese with raw milk: bovine (3.00%), ovine (5.00%), people between 10-20 years of age (2.00%) and people between 20-60 years of age (10.00%). However, the corresponding rates in the region that makes cheese with boiling milk were 2%, 4%, 1% and 5%, respectively. Conclusion:The results were analyzed descriptively and in comparison to the results from the other region. There was a significant difference found between the two regions among the Hinis and Oltu individuals aged 10-20 and 20-60 (z=0.6<1.96 with a 95% confidence interval). Key Words: Boiled milk, dairy products, Human Brucellosis ÖzetAmaç: Bu çalışmada; Türkiye'nin Erzurum ilinde farklı iki yöntemle peynir üreten iki ilçenin kırsalındaki büyük ve küçük baş hayvanlardan, bu hayvanların besisini yaparak peynir üreten insanlardan alı-nan kan örneklerinde Brucella seroprevelansı araştırıldı.Gereç ve Yöntem: Araştırmaya her bölgeden örnekler; 100 sığır, 100 koyun, 10-20 yaş grubu 100 genç çocuk ve 20-60 yaş grubu 100 eriş-kin dahil edildi.Örnekler Rose Bengal Plate Test (RBPT), Serum aglü-tinasyon (SAT), Coombs ve Mikro ELISA yöntemleriyle ayrı ayrı test edildi.Bulgular: Kaynatılmamış sütten peynir yapılan bölgedeki sığırlarda %3.00, koyunlarda %5.00, insanların 10-20 yaş grubunda %2.00 ve 20-60 yaş grubunda ise %10.00 oranında Brucella antikoru pozitif bulundu.Buna karşılık kaynatılmış sütten peynir yapan bölgedeki pozitiflik oranları sırasıyla; %2, %4, %1 ve %5 olarak bulunmuştur.Sonuç: Sonuçlar kendi aralarında ve diğer bölgedeki sonuçlarla tartı-şıldı. 10-20 yaş ve 20-60 yaş arası Hınıs ve Oltu bireyleri karşılaştırması z=0.6<1.96 , iki bölgedeki kişiler arasında %95 güven aralığında fark vardır. İki bölge arasındaki sonuçlarda anlamlı bir farklılık saptandı.

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Section: Discussionmentioning

confidence: 99%

Effects of Boiling Dairy Products on Human Brucellosis

Çelebi

Balkan

2013

EAJM

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“…3,6,7 Although several species of Brucella can cause human infection, B. melitensis and B. abortus are the most frequently implicated species. 8,9 B. melitensis, the more common and virulent cause of human disease, 2,10 is typically associated with sheep and goats, and B. abortus with cattle, although cross-species infections can occur. 2,3,9 Brucella is transmitted to humans by ingestion of infectious animal products, inhalation of airborne particulates, or direct contact with infected animals and their products through skin abrasions or conjunctiva.…”

Section: Introductionmentioning

confidence: 99%

“…8,9 B. melitensis, the more common and virulent cause of human disease, 2,10 is typically associated with sheep and goats, and B. abortus with cattle, although cross-species infections can occur. 2,3,9 Brucella is transmitted to humans by ingestion of infectious animal products, inhalation of airborne particulates, or direct contact with infected animals and their products through skin abrasions or conjunctiva. 2 Although potentially more prevalent in northern Africa, 11,12 human brucellosis seroprevalence ranges from 3% to 8% in sub-Saharan Africa.…”

Section: Introductionmentioning

confidence: 99%

Brucellosis among Hospitalized Febrile Patients in Northern Tanzania

Bouley

Biggs²,

Stoddard³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

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Abstract. Acute and convalescent serum samples were collected from febrile inpatients identified at two hospitals in Moshi, Tanzania. Confirmed brucellosis was defined as a positive blood culture or a 4-fold increase in microagglutination test titer, and probable brucellosis was defined as a single reciprocal titer 160. Among 870 participants enrolled in the study, 455 (52.3%) had paired sera available. Of these, 16 (3.5%) met criteria for confirmed brucellosis. Of 830 participants with 1 serum sample, 4 (0.5%) met criteria for probable brucellosis. Brucellosis was associated with increased median age (P = 0.024), leukopenia (odds ratio [OR] 7.8, P = 0.005), thrombocytopenia (OR 3.9, P = 0.018), and evidence of other zoonoses (OR 3.2, P = 0.026). Brucellosis was never diagnosed clinically, and although all participants with brucellosis received antibacterials or antimalarials in the hospital, no participant received standard brucellosis treatment. Brucellosis is an underdiagnosed and untreated cause of febrile disease among hospitalized adult and pediatric patients in northern Tanzania.

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“…It is endemic in several regions where animal brucellosis is prevalent and is estimated to be the major bacterial zoonosis worldwide. Malta fever is demanding to treat with antibiotics, and there are no vaccines for humans that prevent infection (Memish and Balkhy 2004;Young 2005;Pappas et al 2006;Ariza et al 2007;Pappas 2010). It is transmitted by contact with infected animals, most often goats, sheep, or camels infected with B. melitensis, cattle infected with B. abortus, or swine infected with B. suis.…”

Section: Bartonella and Brucella: Closely Related Pathogens With Distmentioning

confidence: 99%