The changing behaviour of Plasmodium vivax in Colombia relapses despite standard treatment with primaquine

Nicholls, Rubén Santiago; Guerra, Martha Patricia

doi:10.1590/s0074-02761994000600025

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“…Si tenemos en cuenta que en Colombia las infecciones por P. vivax han sido reportadas hasta seis meses después de la exposición (22,23), sugerimos que a los donantes potenciales que han estado en áreas endémicas para malaria en los seis meses previos o más, no se los rechace ni difiera, sino que se les practique una prueba para tamización de malaria en forma previa o posterior a la donación.…”

Section: Financiaciónunclassified

Tamización de malaria en donantes de sangre de Cali, Colombia.

Castillo

Ramírez

2005

biomedica

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Section: Financiaciónunclassified

Tamización de malaria en donantes de sangre de Cali, Colombia.

Castillo

Ramírez

2005

biomedica

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Studies on a Primaquine-Tolerant Strain of Plasmodium vivax from Brazil in Aotus and Saimiri Monkeys

Nayar

Baker²,

Knight³

et al. 1997

The Journal of Parasitology

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A nonimmune American acquired an infection of Plasmodium vivax Type 1 malaria in Brazil in 1994. After returning to the U.S.A., he had a primary attack followed by 3 relapses. The primary attack and first 2 relapses were treated with a standard regimen of chloroquine, followed by 14 days of primaquine (15 mg/day). Following the third relapse, the primaquine treatment was extended to 28 days. No further relapses occurred. The lack of response to primaquine by this strain may recommend it as a suitable candidate for chemotherapeutic study if it can be adapted to an animal model. Anopheles quadrimaculatus mosquitoes infected by feeding on the patient during the first relapse were used to establish the strain in Aotus and Saimiri monkeys. Monkeys supported well the development of long-lasting parasitemia. Anopheles freeborni, Anopheles stephensi, and Anopheles gambiae mosquitoes were readily infected by feeding on the monkeys and by membrane feeding on diluted blood. Monkey-to-monkey transmission was obtained via the bites of infected mosquitoes and the intravenous injection of sporozoites dissected from salivary glands. This parasite is designated as the Brazil I/CDC strain of P. vivax.

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The changing behaviour of Plasmodium vivax in Colombia relapses despite standard treatment with primaquine

Cited by 2 publications

References 0 publications

Tamización de malaria en donantes de sangre de Cali, Colombia.

Tamización de malaria en donantes de sangre de Cali, Colombia.

Studies on a Primaquine-Tolerant Strain of Plasmodium vivax from Brazil in Aotus and Saimiri Monkeys

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