The Changing Aetiology of Oral Cancer and the Role of Novel Biomarkers to Aid in Early Diagnosis

McCullough, Michael; Prasad, Gareema; Zhao, Sarah; Farah, Camile S.

doi:10.5772/36526

Cited by 2 publications

(1 citation statement)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of biological activities like gene regulation, differentiation, organ formation, cell death, cell proliferation, and stress responses have been reported to be influenced by these miRNAs [19][20][21][22]. These miR-NAs were found to regulate translation in larval development through an antisense RNA-RNA interaction [19,23,24]. 1600 miRNAs of Homo sapiens have been reported and recorded by miRBase database in June 2013 [25].…”

Section: Micrornas Discoverymentioning

confidence: 99%

Head and Neck Cancer: Epidemiology and Role of MicroRNAs

Khawar¹,

Fatima²,

Abbasi³

et al. 2017

Diagnosis and Management of Head and Neck Cancer

View full text Add to dashboard Cite

Head and neck cancer (HNC) is referred to the cancers of aerodigestive tract covering number of structures viz, oral and nasal cavity, paranasal sinuses, lips, salivary glands, oropharynx, hypopharynx, pharynx, larynx, and local lymph nodes. It is the sixth most common cancer in the world. MicroRNAs (miRNAs) are small single-stranded noncoding RNAs (ncRNAs) of about 19-25 nucleotides. These miRNAs have been reported to influence number of biological activities, i.e., gene regulation, differentiation, organ formation, cell death, cell proliferation, and stress responses. The first ever study involving miRNAs in HNC was published in 2005. Since then, association between dysregulation of miRNAs and head and neck tumorigenesis has been documented by a number of researchers. This chapter has covered a comprehensive state of the art literature review of the recent studies about the role of miRNAs in HNC including oral squamous cell carcinoma (OSCC) and human nasopharyngeal carcinoma. Despite significant improvement in multimodal treatment, the prognosis of advanced HNC is quite poor. Recent studies are promising regarding the potential role of miRNAs as prognostic indicators. Recently, some miRNAs have been discovered as important diagnostic biomarkers. In fact, miRNAs are found circulated stably in different body fluids, i.e., urine, blood, saliva, as well as in breath. Hence, these miRNAs can be assessed easily with noninvasive methods. miRNAs are the key therapeutic targets in addition to their prognostic and diagnostic value. Use of synthetically designed "miRNAs sponges," miR mimics (agomiRs), miR antagonists ("antagomiRs"), and miR inhibitors (antimiRNAs oligonucleotides) is an innovative strategy to modulate oncogenic and tumor-suppressive pathways. Our understanding of miRNAs involvement in HNC is in its infancy. The discovery of miRNAs heralds a complete new paradigm in the understanding of exact molecular pathways involved in HNC development. More detailed studies are required for better understanding and therapeutic targets to treat HNC.

show abstract

Section: Micrornas Discoverymentioning

confidence: 99%

Head and Neck Cancer: Epidemiology and Role of MicroRNAs

Khawar¹,

Fatima²,

Abbasi³

et al. 2017

Diagnosis and Management of Head and Neck Cancer

View full text Add to dashboard Cite

show abstract

Alcohol-containing Mouthwash and Oral Cancer Risk: A Systematic Review

Mathew¹

2015

Int. Jour. of Dent. and Med. Spec.

View full text Add to dashboard Cite

The aim of this article is to assess any possible risk of oral cancer with increased usage of alcohol-based mouthwashes and to provide relevant information regarding the safety of using alcohol-containing mouth rinses. Materials and Methods: Several controversial studies regarding the prolonged use of such mouthwashes containing >25% alcohol causes oral cancers, have been reviewed and undertaken. Analyzing the number of studies done till date, it showed debatable views on the use of alcohol-containing mouthwashes and its relation with causing oral cancers. Many studies supported the use of alcohol-based mouthwashes can cause oral cancer, while few studies showed no signifi cant relation of mouthwashes with oral cancers. Conclusion: To conclude, the relation between mouthwashes containing alcohol and oral cancers is still a contentious issue in the scientifi c community. On comparing the available reviews, it proved that prolonged use of alcohol-based mouthwashes might cause oral cancers. Thus, it's advisable for the clinicians to educate patients about the ill-effects of long-term use of alcohol-based mouthwashes and to minimize the number of times it's used per day. And to prefer the use of nonalcohol-based mouthwashes instead of the former.

show abstract

The Changing Aetiology of Oral Cancer and the Role of Novel Biomarkers to Aid in Early Diagnosis

Cited by 2 publications

References 87 publications

Head and Neck Cancer: Epidemiology and Role of MicroRNAs

Head and Neck Cancer: Epidemiology and Role of MicroRNAs

Alcohol-containing Mouthwash and Oral Cancer Risk: A Systematic Review

Contact Info

Product

Resources

About