The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension

Dronyk, I.S.; Yavorsky, O.Y.; Sklyarov, Alexander; Pshyk, R.S.

doi:10.25040/aml2019.01.017

Cited by 2 publications

(3 citation statements)

References 12 publications

(10 reference statements)

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“…Íà ñüîãîäí³ â³äîìî, ùî óaeèâàííÿ â³òàì³íó Å ïîêðàùóº åíäîòåë³éçàëåaeíó âàçîäèëàòàö³þ. Â³òàì³í Å ïîïåðåäaeàº îêèñíåííÿ ë³ïîïðîòå¿ä³â íèçüêî¿ ù³ëü-íîñò³ in vivo, éîãî íåòðèâàëå çàñòîñóâàííÿ ïðèçâîäèòü äî ïîë³ïøåííÿ ïåâíèõ ìàðêåð³â åíäîòåë³àëüíî¿ äèñôóíêö³¿ [9].…”

Section: âñòóïmentioning

confidence: 99%

“…Çàñâîºííÿ, ìåòàáîë³çì òà âêëþ÷åííÿ ñåëåíó äî ñêëàäó àì³íîêèñëîò ³ ôåðìåíò³â ò³ñíî ïîâ'ÿçàí³ ³ç çàáåçïå÷åííÿì â³òàì³íîì Å. ²ñíóº òâåðäaeåííÿ, ùî ñåëåí ïîñèëþº àíòèîêñèäàíòíó àêòèâ-í³ñòü â³òàì³íó Å ïðè ¿õ îäíî÷àñíîìó çàñòîñó-âàíí³ [9][10][11][12].…”

Section: âñòóïunclassified

“…[1] Bilivol It is known that stress can lead to transient hypertension [4,5]. However, the exact nature of the stimulus, the duration of the stimulus action so that it can lead to serious consequences, the approach used to determine its connection with the increase of blood pressure (BP), or the method of a quantitative assessment of its strength have not been studied sufficiently [9][10][11]. considered an extremely important mechanism of the disease onset and progression in its early stage.…”

Section: Impact Of Vitamin E and Selenium Intake On Antioxidant Prote...mentioning

confidence: 99%

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Impact of Vitamin E and Selenium Intake on Antioxidant Protection Indicators During Physical Exertion in Individuals With Hypertension

Dronyk,

Dutka,

Chmyr

et al. 2023

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Hypertension remains one of the main problems in modern medicine since it is a pathogenetic factor leading to a large number of cardiovascular diseases and premature death. The aim of the study is to measure and compare the levels of sulfhydryl groups in plasma and blood as well as reduced glutathione of erythrocytes in patients with stage II hypertension before and after engaging in a controlled physical exercise taking into account the intake of vitamin E and selenium. Material and Methods. There were 60 patients with stage II hypertension and 30 relatively healthy individuals. The individuals under observation performed a two-stage physical exercise on a stationary bicycle ergometer with the intensity, corresponding to 50 and 75% of the maximum oxygen consumption by the body. The overall duration of each stage of the physical exercise accounted for 5 minutes with a three-minute break to rest in between. Blood was taken from the ulnar vein before the cardiac stress test and 5 minutes after it. The content of sulfhydryl groups in plasma and erythrocytes, as well as reduced glutathione of erythrocytes was measured in patients before and after the physical exercise. The examination was conducted twice - before and after the intake of vitamin E and selenium. Results and Discussion. Since the immediate response to a cardiac stress test performed on a stationary bicycle is shown by changes in the level of non-protein-bound sulfhydryl groups of erythrocytes (the level decreases), it can be assumed that they are involved in the formation of the primary compensatory reaction in response to physical exercise in individuals suffering from arterial hypertension. Conclusion. Thus, the decrease in the level of non-protein-bound sulfhydryl groups of erythrocytes enables to assess the degree of stress that affects the human body, as well as the antioxidant protection enhancement in patients with hypertension after taking vitamin E and selenium both before and after engaging in physical exercise.

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Section: âñòóïmentioning

confidence: 99%

Section: âñòóïunclassified

Section: Impact Of Vitamin E and Selenium Intake On Antioxidant Prote...mentioning

confidence: 99%

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Impact of Vitamin E and Selenium Intake on Antioxidant Protection Indicators During Physical Exertion in Individuals With Hypertension

Dronyk,

Dutka,

Chmyr

et al. 2023

AML

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Activity of Nitro-Oxidative Processes in Pregnant Women With Idiopathic Arterial Hypotension

Markin

Popovych

2022

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Primary violation of vascular tone and reactivity is considered the main hemodynamic link in the pathogenesis of idiopathic arterial hypotension (IAH). Two gaseous messengers - nitric oxide (NO) and hydrogen sulfide (H2S) play an important role in the regulation of vascular tone. The research aims at determining the state of the NO system and the level of H2S in women with IAH and their effect on the uteroplacental blood flow. Material and Methods. A number of 20 pregnant women with IAH at 40-41 weeks of gestation were examined (group I); the second group included 20 pregnant women with normotony at 39-40 weeks of gestation. The concentration of the complex of nitrates and nitrites was determined by the reaction of formation of a colored complex by Griss reagent. The content and production of peroxynitrite in alkali and alkaline earth metals were determined according to the procedure described by Vanuffelen et al. Detection of hydrogen sulfide content in blood plasma was performed by the method of Dombkowski et al. Studies of uteroplacental blood flow were performed on ultrasonic diagnostic device "SA-8000 EX" using color Doppler mapping and pulse mapping dopplerometry of the blood flow in the uterine arteries (UA). The assessment of blood flow velocity curves was carried out by determining the pulsation index (PI) in both arteries taking into account the average value. Results. The results of the study showed that an average level of nitrites and nitrates in pregnant women with IAH was 37.0% higher than in women with normotension, and peroxynitrite values were 2.4 times higher, respectively. In contrast, the concentration of H2S in pregnant women with IAH was almost 1.4 times lower, than in pregnant women with normal blood pressure. Doppler study of blood flow indices in UA showed a moderate increase in PI in 28.0% of pregnant women with IAH. Thus, indices of vascular resistance in UA of pregnant women with IAH were higher, on average, by 19.0% than in pregnant women with normotension. Conclusions. High levels of nitrites and nitrates in pregnant women with IAH form the basis for the development of nitrosatous stress, which is accompanied by increasing concentration of highly toxic peroxynitrite. Significant increase in peroxynitrite is one of the causes of endothelial dysfunction. In pregnant women with IAH due to the low content of H2S - its vasoconstrictive effects are prevalent, which may indicate an indirect interaction between both of these systems of vasoregulation.

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The changes of some indicators of endothelial dysfunction in response to physical activity in individuals with arterial hypertension

Cited by 2 publications

References 12 publications

Impact of Vitamin E and Selenium Intake on Antioxidant Protection Indicators During Physical Exertion in Individuals With Hypertension

Impact of Vitamin E and Selenium Intake on Antioxidant Protection Indicators During Physical Exertion in Individuals With Hypertension

Activity of Nitro-Oxidative Processes in Pregnant Women With Idiopathic Arterial Hypotension

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