The Changes of Pro-opiomelanocortin Neurons in Type 2 Diabetes Mellitus Rats After Ileal Transposition: The Role of POMC Neurons

Chen, Weijie; Yan, Zhibo; Liu, Shaozhuang; Sun, Dong; Hu, Sanyuan

doi:10.1007/s11605-011-1606-7

Cited by 12 publications

(7 citation statements)

References 43 publications

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“…According to the results, rats in the operated groups showed significantly decreased AUC ITT values at early and long-term points, indicating the ability of SG surgeries to improve IS. This result is consistent with previous studies [22][23][24][25]. However, ITT only roughly estimates IS and could not further assess hepatic and peripheral IS.…”

Section: Discussionsupporting

confidence: 90%

Combining Various Methods to Assess Insulin Sensitivity in Nonobese Rat after Sleeve Gastrectomy

Sun

Wang

et al. 2018

Exp Clin Endocrinol Diabetes

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Section: Discussionsupporting

confidence: 90%

Combining Various Methods to Assess Insulin Sensitivity in Nonobese Rat after Sleeve Gastrectomy

Sun

Wang

et al. 2018

Exp Clin Endocrinol Diabetes

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“…Indeed, another study from our laboratory detected more activated proopiomelanocortin neurons after IT in GK rats and found this upregulation to be associated with improved glucose homeostasis. 23 Other reported explanations for early improvement in insulin sensitivity after gastric bypass included upregulation of insulin signaling pathway and enhanced intestinal gluconeogenesis. Bonhomme et al 24 reported increased levels of phosphorylated insulin receptor substrates 1 and 2 in skeletal muscle and liver tissues and proposed that these contributed to the reversal of diabetes after surgery.…”

Section: Discussionmentioning

confidence: 99%

The Entire Small Intestine Mediates the Changes in Glucose Homeostasis After Intestinal Surgery in Goto-Kakizaki Rats

Liu¹,

Wang²,

Sun³

et al. 2012

Annals of Surgery

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“…The 2016 ADA treatment guidelines even recommend GLP-1 receptor agonists in the treatment of poorly controlled T2DM 6. Our previous study found that the level of GLP-1 in the cerebrospinal fluid (CSF) was significantly elevated after IT, and the pro-opiomelanocortin (POMC) neurons in arcuate nucleus were activated 7. The POMC neuron is a specific population of arcuate nucleus neurons in the hypothalamus 8.…”

Section: Introductionmentioning

confidence: 99%

Blockade of Central GLP-1 Receptors Deteriorates the Improvement of Diabetes after Ileal Transposition

Chen

Xiao

et al. 2016

Int. J. Med. Sci.

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Background: The mechanism of improvement of type 2 diabetes mellitus induced by ileal transposition (IT) is undefined. Our aim was to investigate the possible role of central glucagon-like peptide 1 (GLP-1) after IT.Methods: Ninety male diabetic rats were randomly divided into the IT, sham IT (S-IT) and control group. The food intake, glucose metabolism and GLP-1 level were measured. Subsequently, we administered GLP-1 antagonist via lateral brain ventricle cannula to block central GLP-1 receptor, and verified whether the food intake, glucose metabolism changed. And the activated pro-opiomelanocortin (POMC) neurons in different groups were compared after sacrifice.Results: IT induced significant diabetic improvement with decreased maximum food intake and higher postprandial GLP-1 level. The GLP-1 level in cerebrospinal fluid increased in correlation with the plasma GLP-1 level. When the central GLP-1 receptor antagonist was given to the IT group rats, the improvement of the glucose level declined. The glucose level surged (169.9 ± 14.2) % during the oral glucose tolerance test, the range was larger than that before central blockade ((67.1 ± 14.2) %, P < 0.001). Moreover, the POMC neuron number in the arcuate nucleus of the hypothalamus were reduced (12.7 ± 6.1 at a magnification of 100×). The relative content level of POMC-derived peptides in the pituitary was lower (0.1 ± 0.05).Conclusions: The central GLP-1 might play an important role in the remission of diabetes after IT. POMC neurons in the hypothalamus may be activated by the enhanced level of GLP-1 after IT.

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The Changes of Pro-opiomelanocortin Neurons in Type 2 Diabetes Mellitus Rats After Ileal Transposition: The Role of POMC Neurons

Abstract: More pro-opiomelanocortin neurons in the hypothalamus of diabetes rats were activated after ileal transposition. These data suggest a potential important role for pro-opiomelanocortin neurons in the resolution of diabetes after IT.

Cited by 12 publications

References 43 publications

Combining Various Methods to Assess Insulin Sensitivity in Nonobese Rat after Sleeve Gastrectomy

Combining Various Methods to Assess Insulin Sensitivity in Nonobese Rat after Sleeve Gastrectomy

The Entire Small Intestine Mediates the Changes in Glucose Homeostasis After Intestinal Surgery in Goto-Kakizaki Rats

Blockade of Central GLP-1 Receptors Deteriorates the Improvement of Diabetes after Ileal Transposition

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