The changes of microbiota associated with immunological disturbances in allergic respiratory disease

Abstract

Allergic respiratory disease is a worldwide health problem with increasing incidence and incurable properties. Extensive studies have found complex changes in the microbiota of the respiratory and intestinal tracts in allergic respiratory diseases, which affect the immune response and further influence the disease progression. The wide and diverse microbiota alterations in allergic respiratory disease make it difficult to find the exact microorganism to target for adjustment. Current evidence suggests that these common microbiota variations present in allergic respiratory disease are associated with immune disorders, which could be a potential therapeutic target for allergic respiratory disease. This review summarizes the current knowledge on microbiota changes in allergic respiratory disease, with the aim of identifying common microbiota changes associated with immune disorders and providing a theoretical basis for targeting therapies for allergic respiratory disease through effective modulation of key bacteria.