The Changes of “Carbohydrate Microelementosis” in the Blood From Cubital and Affected Veins of the Lower Extremities of Patients With Varicous Vein Disease and Comorbid Diabetes Mellitus Type-2

Abstract

Abstract. Varicose veins become the most important general medical problem in patients with various comorbid pathologies. A risk factor for the occurrence and adverse course of varicose veins is comorbid diabetes, which significantly worsens the quality of life of such people. According to research, the course of chronic leg skin ulcers is mutually reinforced by the presence of varicose veins and diabetes. The purpose and the objectives of the research: to study the clinical and pathogenetic significance of the changes in the indicators of microelements involved in carbohydrate metabolism in the body of patients with VVD and comorbid DM. Material and methods. Under the survey there were 162 patients with VVD (19% of men and 81% of women with the average age of 50 years) among whom the ratio of classes II, III, IV, V and VI of venous insufficiency was 1:1:3:1:2. DM occurred in 14% of the cases while the distribution of mild, moderate and severe forms of the disease was 1:2:4 and the distribution of the phases of compensation, subcompensation and decompensation 1:4:6. The content of the indicators of chromium (Cr), manganese (Mn), selenium (Se) and zinc (Zn) was studied in the blood from the cubital vein and the affected vein of the lower extremities using atomic absorption spectrometry (SolAAr- Mk2-MOZe, United Kingdom). Results. Among the microelements associated with carbohydrate metabolism varicous vein disease is characterized by hypozincaemia (mostly in men) that is accompanied by lower blood levels of Cr, Se and Zn from varicose veins correlating with the indicators of carbohydrate metabolism (insulin, C-peptide, fructosamine), it depends on the severity of varicous vein disease, the values of the vascular vegetative index and the presence of comorbid diabetes mellitus (Cr, Zn). Conclusion: trace elements associated with carbohydrate metabolism are involved in the pathogenetic constructs of both VVD and comorbid diabetes.