The Changes of Brain-gut SP and VIP Levels in the Rats with
Functional Dyspepsia and the Intervention of Pingwei Capsule

Du, Xin; Liang, Qian-Kun; Zhao, Li; Liang, Jingjing; Mao, Lanfang; Lü, Yanyu; Liu, Junhong; Li, Hongfang; Wang, Longde

doi:10.17554/j.issn.2224-3992.2018.07.749

Cited by 2 publications

(1 citation statement)

References 12 publications

(13 reference statements)

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“…It promotes gastrointestinal peristalsis, protects the gastrointestinal epithelium to repair the impaired gastrointestinal mucosa, and causes gastric and intestinal mechanical hypersensitivity ( Lin et al, 2012 ). PWS had therapeutic effects in rats with functional dyspepsia by influencing both brain–gut substance P and vasoactive intestinal peptide levels ( Du et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study

Lin

Chiu

et al. 2021

Front. Pharmacol.

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Objective: Combinations of Chinese herbal products (CHPs) are widely used for Parkinson’s disease (PD) in Taiwan. Thereby, we investigated the use of CHPs in patients with PD.Methods: This study was a population-based cohort study that analyzed the data of patients with PD from the National Health Insurance Research Database. A total of 9,117 patients were selected from a random sample of one million individuals included in this database. We used multiple logistic regression models to estimate the adjusted odds ratios of the demographic factors and analyzed the formula and single CHPs commonly used for PD.Results: Traditional Chinese medicine users were more commonly female, younger, of white-collar status, and residents of Central Taiwan. Chaihu-Jia-Longgu-Muli-Tang was the most commonly used formula, followed by Ma-Zi-Ren-Wan and then Shao-Yao-Gan-Cao-Tang. The most commonly used single herb was Uncaria tomentosa (Willd. ex Schult.) DC., followed by Gastrodia elata Blume and then Radix et Rhizoma Rhei (Rheum palmatum L., Rheum tanguticum Maxim. ex Balf., and Rheum officinale Baill.). Chaihu-Jia-Longgu-Muli-Tang and U. tomentosa (Willd. ex Schult.) DC. have shown neuroprotective effects in previous studies, and they have been used for managing non-motor symptoms of PD.Conclusion: Chaihu-Jia-Longgu-Muli-Tang and U. tomentosa (Willd. ex Schult.) DC. are the most commonly used CHPs for PD in Taiwan. Our results revealed the preferences in medication prescriptions for PD. Further studies are warranted to determine the effectiveness of these CHPs for ameliorating the various symptoms of PD, their adverse effects, and the mechanisms underlying their associated neuroprotective effects.

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Section: Discussionmentioning

confidence: 99%

Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study

Lin

Chiu

et al. 2021

Front. Pharmacol.

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Oral suspension of thaliporphine alter the functional dyspepsia in gastroduodenal lesions rats via gastrointestinal hormones and brain-gut peptides

Yang,

Liu,

2023

mat express

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Functional dyspepsia (FD), also known as nonulcer dyspepsia, is distinguished by epigastric burning or pain, nausea, a feeling of being overly full, and bloating. Thaliporphine an alkaloid exhibited the protective effect against the inflammatory reaction and oxidative stress. Our aim to scrutinized the therapeutic potential of thaliporphine against FD in rats. Sprague-Dawley (SD) rats were randomised into six groups at random, and the FD model was created using irregular tail clamp stimulation over 14 days (except from rats in the control group). The normal and model group rats got menstruum and thaliporphine oral administration for 14 days after the FD rat models were effectively established. The body weight, food and water intake were estimated. The level of plasma gastrin (GAS), motilin (MTL), vasoactive intestinal peptide (VIP), somatostatin (SS), calcitonin gene-related peptide (CGRP), acetylcholine (AChE), antioxidant, cytokines and inflammatory parameters were estimated. Thaliporphine treated group rats exhibited the increased body weight and food intake, which was suppressed during the FD. Thaliporphine significantly increased the rate of intestinal propulsion and gastric emptying in addition to changing the levels of leptin, CGRP, MLT, SS, and VIP. Thaliporphine significantly (P <0.001) reduced the level of AChE in serum and boosted the level in stomach and hypothalamus. Thaliporphine significantly changed the cytokine and inflammatory parameter levels. Treatment with thaliporphine improves gut peptide levels, controls the peripheral and central nervous systems, and restores levels of gastrointestinal hormones, all of which point to the drug’s potential for protecting against FD.

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The Changes of Brain-gut SP and VIP Levels in the Rats with Functional Dyspepsia and the Intervention of Pingwei Capsule

Cited by 2 publications

References 12 publications

Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study

Chinese Herbal Products for Non-Motor Symptoms of Parkinson’s Disease in Taiwan: A Population-Based Study

Oral suspension of thaliporphine alter the functional dyspepsia in gastroduodenal lesions rats via gastrointestinal hormones and brain-gut peptides

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