The changes in the vascular pattern of the ovary of the albino rat during the estrous cycle

Bassett, David L.

doi:10.1002/aja.1000730206

Cited by 205 publications

(88 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1a). New CL were well vascularized, whereas CL present on the ovary from past cycles were less vascularized (Bassette 1943). There was no attempt to discern the differences between old CL regarding how many cycles they had been present on the ovary.…”

Section: Tissue Culturesupporting

confidence: 38%

Potential role for peroxisome proliferator-activated receptor γ in regulating luteal lifespan in the rat

Tinfo

Komar

2007

Reproduction

View full text Add to dashboard Cite

Peroxisome proliferator-activated receptor g (PPARg) has been shown to stimulate progesterone production by bovine luteal cells. We previously reported higher expression of PPARg in old compared with new luteal tissue in the rat. The following studies were conducted to determine the role of PPARg in rat corpora lutea (CL) and test the hypothesis that PPARg plays a role in the metabolism of progesterone and/or luteal lifespan. Ovaries were removed from naturally cycling rats throughout the estrous cycle, and pseudopregnant rats. mRNA for PPARg and P450 side-chain cleavage (SCC) was localized in luteal tissue by in situ hybridization, and protein corresponding to PPARg and macrophages identified by immunohistochemistry. Luteal tissue was cultured with agonists (ciglitazone, prostaglandin J 2 ) or an antagonist (GW-9662) of PPARg. Progesterone was measured in media by RIA and levels of mRNA for 20a-hydroxysteriod dehydrogenase (HSD) and bcl-2 were measured in luteal tissue after culture by RT-PCR. An inverse relationship existed between the expression of mRNA for SCC and PPARg. There was no effect of PPARg agonists or the antagonist on luteal progesterone production in vitro, or levels of mRNA for 20a-HSD. PPARg protein was localized to the nuclei of luteal cells and did not correspond with the presence of macrophages. In new CL, ciglitazone decreased mRNA for bcl-2 on proestrus, estrus, and metestrus. Interestingly, GW-9662 also decreased mRNA for bcl-2 on proestrus and diestrus in old and new CL, and on metestrus in new CL. These data indicate that PPARg is not a major player in luteal progesterone production or metabolism but may be involved in regulating luteal lifespan.

show abstract

Section: Tissue Culturesupporting

confidence: 38%

Potential role for peroxisome proliferator-activated receptor γ in regulating luteal lifespan in the rat

Tinfo

Komar

2007

Reproduction

View full text Add to dashboard Cite

show abstract

“…The changes found in the clp which were observed in the present study ap¬ pear to be similar to those reported by Deanesly (1930) and Bassett (1943) in involuting cl. Loeb (1948) Finn (1963) that pregnancy failed earlier in gestation with increasing maternal age.…”

Section: Discussionmentioning

confidence: 49%

The Effect of Maternal Age on Ovulation, Corpora Lutea of Pregnancy, and Implantation Failure in Mice

Harman¹,

Talbert²

1970

Reproduction

View full text Add to dashboard Cite

Summary. C57B1 female mice aged 4 to 7 months (controls) and 8 to 9, 10 to 11, 12 to 13, and 14 to 15 months were mated and killed at 12 hr, 60 hr or 7\ m=1/ 2\ days post coitum (p.c.). Corpora lutea were counted and evaluated in serially sectioned ovaries. Implantation sites were counted in the animals killed 7\ m=1/ 2\ days p.c. The mean number of implantations in 10-to 11-month-old mice was less than in the control animals. This decrease was closely associated with morphological degeneration of corpora lutea of pregnancy. By 12 to 13 months of age most animals had neither implantation sites nor recognizable corpora lutea of pregnancy 7\ m=1/ 2\ days after mating. These two changes were highly correlated and were not due to a decrease in the number of ovulations as determined by examination of the ovaries of animals killed 12 or 60 hr p.c.It was concluded that the initial decline in fertility with increased maternal age in this strain of mouse may be due to failure of luteal support of the uterus.

show abstract

“…In the past, 3D studies of ovarian vascularization were performed by light microscopic observations of serial sections of dye-injected samples [9][10][11][12], followed by graphic reconstruction and drawings. Angiography [13,14], diaphanoscopy [15,16] and microangiography of sectioned ovaries [15,17] have also been usefully applied to the study of the anatomy and topography of the ovarian vessels.…”

Section: Historical Backgroundmentioning

confidence: 47%

The Microvasculature of the Ovary. A Review by SEM of Vascular Corrosion Casts.

Macchiarelli

2000

Journal of Reproduction and Development

View full text Add to dashboard Cite

Abstract. The vascular changes of the ovary were studied by scanning electron microscopy of vascular corrosion casts in estrous, pseudopregnant (stimulated with human chorionic gonadotropin -hCG) and pregnant rabbits. The results demonstrated that ovarian cycle and pregnancy may induce both structural and functional changes in the ovarian vessels. In fact the ovarian blood vessels adapted their structure to the temporary functional needs of the recruited follicles or corpora lutea. These changes involved both larger ovarian blood vessels (supplying the hilus and the medulla) and cortical blood vessels (supplying the luteo-follicular complexes). Hilar and medullary blood vessels also displayed morphological devices for the continuous control of the blood flow (spiral arteries) and for the local recirculation of endocrine products (artero-venous contacts). Such contacts, may likely sustain a "countercurrent mechanism" which was also shown in ovaries of other species. Scanning electron microscopy of vascular corrosion casts even demonstrated that cortical blood vessels are subjected to continuous remodeling. SEM showed different morphological types of vascular plexuses which supplied antral follicles (Types 1-2), atretic follicles (Types 3-4), peri-ovulatory follicles (Type 5), growing pseudopregnant corpora lutea (Type 6) regressing pseudopregnant corpora lutea (Type 7) and pregnant corpora lutea (Type 8). In estrous rabbit, growing to mature follicles (Types 1-2) showed a gradual enlargement and proliferation of the theca capillaries. These changes, associated with capillary hyperpermeabilization were observed in ovulatory and post-ovulatory follicles (Type 5), after hCG stimulation. The corpus luteum formation (Type 6 and 8) was accompanied by additional capillary dilation, diffuse angiogenetic sprouting and organization of conspicuous venous drainage which appeared more enhanced in pregnant (type 8) than in pseudopregnant (type 6) corpora lutea. The regression of the corpus luteum (Type 7) was characterized by the appearance of avascular areas within the gland and by regression of vascular dilatation. Finally, in estrous rabbit the atretic follicles (Types 3-4) wall showed large interruptions (avascular areas) and focal invasion of the central cavity by newly formed capillaries arranged randomly. The hCG stimulation did not affect consistently the interstitial microvasculature. It is concluded that the gradual increase of ovarian blood flow occuring during follicle growth and corpora lutea formation is provided by a functional adaptation of major ovarian vessels and by capillary functional (vasodilation) and structural (angiogenesis) support as well. Key words: Ovary, Blood vessels, Capillary, Corrosion casts, Angiogenesis, Scanning electron microscopy, Rabbit.(J. Reprod. Dev. 46: [207][208][209][210][211][212][213][214][215][216][217][218][219][220][221][222][223][224][225] 2000) ndocrine and ovulatory activities of the ovary have strict and continuous relationship with -Reviewblood vessels changes. In fact...

show abstract

The changes in the vascular pattern of the ovary of the albino rat during the estrous cycle

Cited by 205 publications

References 14 publications

Potential role for peroxisome proliferator-activated receptor γ in regulating luteal lifespan in the rat

Potential role for peroxisome proliferator-activated receptor γ in regulating luteal lifespan in the rat

The Effect of Maternal Age on Ovulation, Corpora Lutea of Pregnancy, and Implantation Failure in Mice

The Microvasculature of the Ovary. A Review by SEM of Vascular Corrosion Casts.

Contact Info

Product

Resources

About