The changes in the <sup>18</sup>F FDG metabolism in the muscles by the use of cuboid support insoles

Okumura, Norihisa; Okada, Yukinori; Kumai, Keiichi; Hosokawa, Tomomitsu; Oonuma, Jiro; Takata, Yuichi; Ito, Masatoshi

doi:10.4103/ijnm.ijnm_188_21

Cited by 3 publications

(3 citation statements)

References 9 publications

(10 reference statements)

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“…We analyzed the PET–CT images used for initial staging. PET–CT was performed by a radiologist (OY) who is a radiation oncologist, a nuclear medicine specialist, and a PET nuclear medicine-certified physician with experience in PET–CT-related research (Sawaragi et al 2023 ; Okumura et al 2022 ). The PET–CT images were visually evaluated by the same radiologist (OY).…”

Section: Methodsmentioning

confidence: 99%

Association between PET–CT accumulation in the hypothalamic/pituitary regions and neuron-specific enolase/primary tumor in limited-stage small cell lung cancer: a case-controlled retrospective study

Okada,

Zama,

Itonaga

et al. 2024

EJNMMI Rep.

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Background Research on the relationship between neuron-specific enolase (NSE) levels and normal organs, particularly the central nervous system, in small cell lung cancer is limited. Therefore, this study aimed to investigate the relationship between positron emission tomography–computed tomography (PET–CT) accumulation at hypothalamic/pituitary regions, tumor activity, and NSE level in limited-stage small cell lung cancer. We retrospectively analyzed patients who were diagnosed with limited-stage small cell lung cancer at Tokyo Medical University Hospital between July 1, 2019, and May 31, 2023, and were treated with chemoradiotherapy or radiotherapy. Leukocytes, erythrocytes, hemoglobin, platelets, total protein, albumin, NSE, and carcinoembryonic antigen were measured in blood samples obtained before treatment initiation. The maximum standardized uptake value (SUVmax), volume, and total lesion glycolysis (TLG) of each hypothalamic /pituitary region, primary tumor, and lymph node metastases were extracted from PET–CT images. The total tumor volume (primary tumor volume plus lymph node metastases volume) and total TLG (primary tumor TLG plus lymph node metastases TLG) were calculated. Results This study included 19 patients (mean age, 70.1 ± 8.8 years; 13 men and 6 women); the pathology in all patients was small cell lung cancer. Patients were classified into two groups according to the NSE reference value (16.3 ng/mL): six patients having NSE level below the reference value and 13 having NSE level above the reference value. The SUVmax in the hypothalamic/pituitary region was 2.95 in the NSE < 16.3 ng/mL group and 4.10 in the NSE > 16.3 ng/mL group, with a statistically significant difference (p = 0.03). The total tumor volume was 17.8 mL in the NSE < 16.3 ng/mL group and 98.9 mL in the NSE > 16.3 ng/mL group, with a statistically significant difference (p < 0.01). A correlation coefficient of r = 0.458 (p = 0.0486) was observed between SUVmax in the hypothalamus/pituitary and NSE level. A correlation coefficient of r = 0.647 (p < 0.01) was also observed between total tumor volume and NSE level. Finally, a correlation coefficient of r = 0.53 (p = 0.01) was observed between hypothalamic/pituitary TLG and primary tumor TLG. Conclusions The findings demonstrated a correlation between hypothalamic/pituitary activity and tumor activity, suggesting the prognostic significance of NSE.

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Section: Methodsmentioning

confidence: 99%

Association between PET–CT accumulation in the hypothalamic/pituitary regions and neuron-specific enolase/primary tumor in limited-stage small cell lung cancer: a case-controlled retrospective study

Okada,

Zama,

Itonaga

et al. 2024

EJNMMI Rep.

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“…PET images, CT images and fusion images were prepared from the PET-CT scan. PETCT images were visually assessed by a radiologist (author Yukinori Okada) with experience the PET research ( 17 ), a boardcertified radiologist and radiation oncologist (Japan Radiological Society and Japanese Society for Radiation Oncology) and a boardcertified nuclear medicine specialist (Japan Society of Nuclear Medicine).…”

Section: Methodsmentioning

confidence: 99%

Cardiac 18F‑FDG uptake and new‑onset rectal cancer

Sawaragi¹,

Okada²,

Aono³

et al. 2023

Oncol Lett

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The present study aimed to investigate the factors affecting the cardiac uptake of 18F-fluorodeoxyglucose (18F-FDG) during 18F-FDG positron emission tomography (PET) for new-onset rectal cancer and new-onset colon cancer (ascending, transverse, descending, sigmoid colon cancer) and to examine the association between the cardiac uptake of 18F-FDG and prognosis. The participants were diagnosed with new-onset rectal cancer and new-onset colon cancer (ascending, transverse, descending, sigmoid cancer) at the Iga City General Hospital (Iga, Japan) between January 1, 2013, and March 31, 2018, and underwent an 18F-FDG PET scan for pretreatment staging. The relationship between cardiac maximum standard uptake value (SUVmax), the presence/ absence of distant metastasis and prognosis was examined. A total of 26 patients (14 men and 12 women) aged 72.0±10 years with new-onset rectal cancer were selected for the study. No patients had multiple simultaneous cancers. The median cardiac SUVmax was 3.8 and 2.5 in patients with no distant metastasis and distant metastasis, respectively, revealing a statistically significant difference (P<0.01). The median tumor volume on PET-computed tomography (CT) images was 7,815 cm 2 and was 66,248 cm 2 in patients with no distant metastasis and distant metastasis, respectively, revealing a statistically significant difference (P<0.01). Echocardiography findings revealed no significant difference between patients with and without distant metastasis. The correlation coefficient between cardiac SUVmax and total tumor volume on PET/CT images (primary + lymph + distant metastases) was statistically significant (r=-0.42, P=0.03). Analysis of the association between the occurrence of distance metastasis and cardiac SUVmax as a continuous variable gave a statistically significant result [hazard ratio (HR): 0.30, 95% confidence interval (CI): 0.09-0.98, P=0.045]. Receiver operating characteristic analysis showed a cardiac SUVmax of 2.6 with an area under the curve of 0.86 for determining the presence of distant metastasis (95% CI: 0.70-1.00). The median observation time was 56 months, and nine patients died during observation. Analysis of the association between the overall survival and cardiac SUVmax (cutoff: 2.6) showed 95% CI: 0.01-0.45 and HR: 0.06 (P<0.01); that between the overall survival and total tumor volume on PET images showed 95% CI: 1.00-1.00 and HR: 1.00 (P<0.01); and that between the overall survival and presence of distant metastasis showed 95% CI: 1.72-116.4 and HR: 14.1 (P<0.01). Furthermore, 25 patients (16 men and nine women) aged 71.4±14.2 years with new-onset colon cancer were selected for the study. Analysis of new-onset colon cancer revealed no statistically significance between the cardiac SUVmax and distant metastasis.

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“…We analyzed the PET-CT images used for initial staging. PET-CT images were taken by a radiologist (OY) who is a radiation oncologist, a nuclear medicine specialist, and a PET nuclear medicine-certi ed physician with experience in PET-CT-related research [11,12]. A radiologist (OY) evaluated the PET-CT images by visual evaluation.…”

Section: Analysis Of Pet-ct Imagesmentioning

confidence: 99%

Association between PET-CT accumulation in the hypothalamic /pituitary regions and neuron-specific enolase /primary tumor in limited-stage small cell lung cancer

Okada,

Zama,

Itonaga

et al. 2023

Preprint

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Objective: This study aimed to investigate the relationship between positron emission tomography-computed tomography (PET-CT) accumulation at hypothalamic /pituitary regions, tumor, and neuron-specific enolase (NSE) in limited-stage small cell lung cancer. Methods: We analyzed patients who were diagnosed with limited-stage small cell lung cancer at Tokyo Medical University Hospital between July 1, 2019 and May 31, 2023 and who underwent chemoradiotherapy or radiotherapy. Leukocytes, erythrocytes, hemoglobin, platelets, total protein, albumin, NSE, and carcinoembryonic antigen were measured in blood samples taken before the start of treatment. In PET-CT, the maximum standardized uptake value (SUVmax), volume. total lesion glycolysis (TLG) of the hypothalamic /pituitary regions, primary tumor, lymph node metastases were extracted. And total tumor volume (primary tumor and lymph node metastases), total TLG (primary tumor and lymph node metastases) were calculated. Results: A total of 19 patients were selected (mean age 70.1±8.8 years; 13 male and six female). The pathology of all cases was small cell lung cancer. Cases were classified into two groups according to the NSE standard value (16.3 ng/mL); six cases were below the standard value and 13 were above the standard value. The SUVmax in the hypothalamic/pituitary region was 2.95 in the NSE <16.3ng/mL group and 4.10 in the NSE >16.3ng/mL group, showing a statically significant difference (p=0.03).The total tumor volume was 17.8 ml in the NSE <16.3ng/mL group and 98.9 ml in the NSE >16.3ng/mL group, showing a statically significant difference (p<0.01).A correlation coefficient of r=0.458 and p=0.0486 was observed between SUVmax in the hypothalamus/pituitary and NSE. A correlation coefficient of r=0.647 and p<0.01 was observed between total tumor volume and NSE. A correlation coefficient of r=0.53 and p=0.01 was observed between hypothalamic/pituitary TLG and primary tumor TLG. Conclusions: There was correlation between hypothalamic/pituitary activity and tumor activity.

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The changes in the ¹⁸F FDG metabolism in the muscles by the use of cuboid support insoles

Cited by 3 publications

References 9 publications

Association between PET–CT accumulation in the hypothalamic/pituitary regions and neuron-specific enolase/primary tumor in limited-stage small cell lung cancer: a case-controlled retrospective study

Association between PET–CT accumulation in the hypothalamic/pituitary regions and neuron-specific enolase/primary tumor in limited-stage small cell lung cancer: a case-controlled retrospective study

Cardiac 18F‑FDG uptake and new‑onset rectal cancer

Association between PET-CT accumulation in the hypothalamic /pituitary regions and neuron-specific enolase /primary tumor in limited-stage small cell lung cancer

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The changes in the 18F FDG metabolism in the muscles by the use of cuboid support insoles

Cited by 3 publications

References 9 publications

Association between PET–CT accumulation in the hypothalamic/pituitary regions and neuron-specific enolase/primary tumor in limited-stage small cell lung cancer: a case-controlled retrospective study

Association between PET–CT accumulation in the hypothalamic/pituitary regions and neuron-specific enolase/primary tumor in limited-stage small cell lung cancer: a case-controlled retrospective study

Cardiac 18F‑FDG uptake and new‑onset rectal cancer

Association between PET-CT accumulation in the hypothalamic /pituitary regions and neuron-specific enolase /primary tumor in limited-stage small cell lung cancer

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The changes in the ¹⁸F FDG metabolism in the muscles by the use of cuboid support insoles