The changes in cardiac physiology with aging and the implications for the treating oncologist

Gupta, Dhiraj; Verma, Shivani; Pun, Shawn C.; Steingart, Richard M.

doi:10.1016/j.jgo.2015.02.004

Cited by 3 publications

(1 citation statement)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although cardiac reserve decreases depending on age in the cardiovascular system, vascular stiffness and left ventricular diastolic function disorder occur. Anatomical chan- ges observed in the heart begin at cellular level ( 14 ). Moreover, with aging, a decrease in mitochondrial functions and an increase in free oxygen radicals is observed.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the effects of aging on the expression of aquaporin 1 and aquaporin 4 protein in heart tissue

et al. 2016

View full text Add to dashboard Cite

Objective:Aquaporin (AQP) 1 and AQP 4 are expressed in human heart and several studies have been focused on these two aquaporins. For this purpose, the present study is aimed to research the effects of aging on AQP 1 and AQP 4 in heart tissue.Methods:In this study, 14 Balb/C type white mice were used. Animals were divided into two equal groups. Group I consisted of 2-month-old young animals (n=7), and group II consisted of 18-month-old animals (n=7). To determine the AQP1 and AQP4 expression in the myocardium, the heart tissue was removed to perform western blotting and immunohistochemical and histopathological evaluations.Results:Muscle fibers of the heart in aged animals were more irregular and loosely organized in hematoxylin–eosin (H&E) stained sections. H-score analysis revealed that AQP1 and AQP4 immunoreactivity significantly increased in heart tissues of old mice compared with those of young mice (p<0.001). In addition, AQP1 and AQP4 protein expressions in the tissues of old animals were increased significantly according to western blot analysis (p=0.018 and p<0.001 for AQP1 and AQP4, respectively).Conclusion:Increased AQP1 and AQP4 levels in the heart tissue may be correlated with the maintenance of water and electrolytes balance, which decreases with aging. In this context, it might be the result of a compensatory response to decreased AQP4 functions. In addition, this increase with aging as demonstrated in our study might be one of the factors that increases the tendency of ischemia in elder people.

show abstract

Section: Discussionmentioning

confidence: 99%