The Change of the Rate‐Controlling Processes with Temperature in the Hydration of Anhydrous Nedocromil Sodium by Water Vapor

Solvation Mechanisms of Nedocromil Sodium From Activation Energy and Reaction Enthalpy Measurements of Dehydration and Dealcoholation

“…The subsequent crystal growth is three‐dimensional. In our theoretical paper2 a question was raised concerning the dimensionality of the nucleation process. Only one stage has been amenable to study here, and in that stage it appears that nucleation is a bulk phenomenon and anhydrate growth is a three‐dimensional process.…”

“…Isothermal reaction rate data obtained thermogravimetrically for the hydration of nedocromil sodium (NS; di‐sodium 9‐ethyl‐4,6‐dioxo‐10‐propyl‐4H,6H pyranol[3,2‐g]quinoline‐2,8‐dicarboxylic) trihydrate; trade name, Tilade) was analyzed theoretically in our earlier publications on this system 1,2. A dominant role for the nucleation process of the hydrate phases in this system was inferred but was not researched at the time.…”