The change in intraocular pressure after pupillary dilation in eyes with pseudoexfoliation glaucoma, primary open angle glaucoma, and eyes of normal subjects

Atalay, Eray; Tamçelik, Nevbahar; Arıcı, Ceyhun; Özkök, Ahmet; Dastan, Metin

doi:10.1007/s10792-014-9935-7

Cited by 8 publications

(9 citation statements)

References 20 publications

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“…Our model discovers that these two drugs may have a strong relationship with the abnormally increased intraocular pressure. This is highly consistent with medical literature [3,29,41,46] and clinician experience, which confirm that the two drugs can lead to adverse reactions like elevation of IOP and should be used with caution for specific patients in clinical practice.…”

Section: Discussionsupporting

confidence: 87%

“…However, such methods can not handle the samples in need with missing modalities and have limitations to be applied in rigid demand domains like healthcare. Besides, such methods dramatically reduce training data and result in over-fitting of deep learning models [9,45], especially when there are many modalities and many different missing combination patterns 3 .…”

Section: Related Workmentioning

confidence: 99%

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M3Care: Learning with Missing Modalities in Multimodal Healthcare Data

Zhang

Chu

et al. 2022

Proceedings of the 28th ACM SIGKDD Conference on Knowledge Discovery and Data Mining

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Multimodal electronic health record (EHR) data are widely used in clinical applications. Conventional methods usually assume that each sample (patient) is associated with the unified observed modalities, and all modalities are available for each sample. However, missing modality caused by various clinical and social reasons is a common issue in real-world clinical scenarios. Existing methods mostly rely on solving a generative model that learns a mapping from the latent space to the original input space, which is an unstable ill-posed inverse problem. To relieve the underdetermined system, we propose a model solving a direct problem, dubbed learning with Missing Modalities in Multimodal healthcare data (M 3 Care). M 3 Care is an end-to-end model compensating the missing information of the patients with missing modalities to perform clinical analysis. Instead of generating raw missing data, M 3 Care imputes the task-related information of the missing modalities in the latent space by the auxiliary information from each patient's similar neighbors, measured by a task-guided modality-adaptive similarity metric, and thence conducts the clinical tasks. The taskguided modality-adaptive similarity metric utilizes the uncensored modalities of the patient and the other patients who also have the * Both authors contributed equally to this research.

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Section: Discussionsupporting

confidence: 87%

Section: Related Workmentioning

confidence: 99%

M3Care: Learning with Missing Modalities in Multimodal Healthcare Data

Zhang

Chu

et al. 2022

Proceedings of the 28th ACM SIGKDD Conference on Knowledge Discovery and Data Mining

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“…Instillation of tropicamide was made before pre-dive measures, and so does not explain our results. Effects of tropicamide on IOP vary in literature [ 68 , 69 , 70 , 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of SCUBA Diving on Ophthalmic Parameters

et al. 2022

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Background and Objective: Several cases of central serous chorioretinopathy (CSC) in divers have been reported in our medical retina center over the past few years. This study was designed to evaluate possible changes induced by SCUBA diving in ophthalmic parameters and especially subfoveal choroidal thickness (SFCT), since the choroid seems to play a crucial role in physiopathology of CSC. Materials and Methods: Intraocular pressure (IOP), SFCT, pachymetry, flow-mediated dilation (FMD), blood pressure, and heart rate were measured in 15 healthy volunteer divers before diving, 30 and 60 min after a standard deep dive of 25 m depth for 25 min in a dedicated diving pool (NEMO 33). Results: SFCT reduces significantly to 96.63 ± 13.89% of pre-dive values (p = 0.016) 30 min after diving. It recovers after 60 min reaching control values. IOP decreases to 88.05 ± 10.04% of pre-dive value at 30 min, then increases to 91.42 ± 10.35% of its pre-dive value (both p < 0.0001). Pachymetry shows a slight variation, but is significantly increased to 101.63 ± 1.01% (p = 0.0159) of the pre-dive value, and returns to control level after 60 min. FMD pre-dive was 107 ± 6.7% (p < 0.0001), but post-dive showed a diminished increase to 103 ± 6.5% (p = 0.0132). The pre-post difference was significant (p = 0.03). Conclusion: Endothelial dysfunction leading to arterial stiffness after diving may explain the reduced SFCT observed, but SCUBA diving seems to have miscellaneous consequences on eye parameters. Despite this clear influence on SFCT, no clear relationship between CSC and SCUBA diving can be drawn.

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“…5 mmHg und damit deutlich häufiger als Patienten ohne Glaukom. Bei bis zu 30 % dieser Patienten ist ein signifikanter Druckanstieg feststellbar, wobei Patienten mit PEX-Glaukom und PEX-Syndrom (PEX: Pseudoexfoliation) häufiger betroffen sind als Patienten mit primär chronischem Offenwinkelglaukom [22]. Bei Patienten mit PEX-Syndrom kann ein früher leichter Druckanstieg nach Mydriase (1 h nach Applikation) Vorbote eines zeitlich verzögerten stärkeren Druckanstiegs (2-3 h nach Applikation) sein, der durch eine Pigmentausschüttung nach Mydriase ausgelöst wird [23].…”

Section: Pupillenwirksame Medikamenteunclassified

Der Einfluss von Medikamenten auf das Glaukom und den Augeninnendruck

Schlote¹

2017

Klin Monatsbl Augenheilkd

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Systemic drugs may have unfavourable effects on intraocular pressure, glaucoma and the efficacy of glaucoma drugs. The article provides a review of the literature from PubMed and clinical experience. Topical and systemic corticosteroids induce complex changes inside the trabecular meshwork. New genetic results improve the understanding of pathogenetic processes, although many questions are still open. Arterial hypertension and antihypertonic drugs may influence the risk of glaucoma, intraocular pressure and ocular perfusion pressure. Intravitreal anti-VEGF therapy may be associated with the risk of sustained intraocular pressure elevation. Systemic drugs with parasympaticolytic activity (e.g. psychopharmaceuticals) are able to induce acute angle block glaucoma. New insights into the interactions between drugs (e.g. antihypertensives, corticosteroids) and glaucomatous optic neuropathy affect large patient groups and may improve understanding of the underlying pathogenetic processes in open angle glaucoma. There is a great need for further clinical and experimental research.

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The change in intraocular pressure after pupillary dilation in eyes with pseudoexfoliation glaucoma, primary open angle glaucoma, and eyes of normal subjects

Cited by 8 publications

References 20 publications

M3Care: Learning with Missing Modalities in Multimodal Healthcare Data

M3Care: Learning with Missing Modalities in Multimodal Healthcare Data

Effect of SCUBA Diving on Ophthalmic Parameters

Der Einfluss von Medikamenten auf das Glaukom und den Augeninnendruck

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