The Change in Biological Activities of Brown Rice and Germinated Brown Rice

김대중,; 오세관,; 윤미라,; 천아름,; 최임수,; 이동현,; 이준수,; 유광원,; 김연규,

doi:10.3746/jkfn.2011.40.6.781

Cited by 22 publications

(9 citation statements)

References 19 publications

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“…They showed that germinating BR in tap water at 25°C significantly improved total phenolic content of BR and antioxidant activities as determined by DPPH and ABTS radical scavenging activity and ferric reducing antioxidant power ( P < 0.05). Others have also reported similar findings [22, 23, 30, 35, 40]. Jiamyangyuen and Ooraikul [59] had reported also that GBR had lower amylose content consistent with reports in which activation of amylase enzyme was responsible for higher amounts of bioactives in GBR [60].…”

Section: Germination Of Brown Ricesupporting

confidence: 78%

“…As can be recalled, Tian et al [18] and Kim et al [35] reported that GBR grains had improved antioxidant capacity, which could potentially reduce oxidative stress. In addition, Usuki et al [58] showed that reduction of oxidative stress by GBR may be due to its acylated steryl glycoside (ASG) content.…”

Section: Studies On Mechanisms For Antidiabetic Effects Of Germinamentioning

confidence: 99%

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Antidiabetic Properties of Germinated Brown Rice: A Systematic Review

Imam

Azmi

Bhanger

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Diet is an important variable in the course of type 2 diabetes, which has generated interest in dietary options like germinated brown rice (GBR) for effective management of the disease among rice-consuming populations. In vitro data and animal experiments show that GBR has potentials as a functional diet for managing this disease, and short-term clinical studies indicate encouraging results. Mechanisms for antidiabetic effects of GBR due to bioactive compounds like γ-aminobutyric acid (GABA), γ-oryzanol, dietary fibre, phenolics, vitamins, acylated steryl β-glucoside, and minerals include antihyperglycemia, low insulin index, antioxidative effect, antithrombosis, antihypertensive effect, hypocholesterolemia, and neuroprotective effects. The evidence so far suggests that there may be enormous benefits for diabetics in rice-consuming populations if white rice is replaced with GBR. However, long-term clinical studies are still needed to verify these findings on antidiabetic effects of GBR. Thus, we present a review on the antidiabetic properties of GBR from relevant preclinical and clinical studies, in order to provide detailed information on this subject for researchers to review the potential of GBR in combating this disease.

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Section: Germination Of Brown Ricesupporting

confidence: 78%

Section: Studies On Mechanisms For Antidiabetic Effects Of Germinamentioning

confidence: 99%

Antidiabetic Properties of Germinated Brown Rice: A Systematic Review

Imam

Azmi

Bhanger

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…The anti-cancer effect of GRR extract was higher compared with raw rough rice extract and associated with the increased antioxidative activity by germination [49]. Similarly, the ethanol extract of GBR showed antiproliferative, antioxidative and immunological activities in HCT116 cells [50]. Another study indicated that the ethanol extract of GBR had high inhibitory activity against HT-29 cells and the enhanced antiproliferative and antioxidative effects may be due to the increased bioactive compounds after germination [51].…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus acidophilus-Fermented Germinated Brown Rice Suppresses Preneoplastic Lesions of the Colon in Rats

Lin

Chang

et al. 2019

Nutrients

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Colorectal cancer (CRC) is a cancer associated with chronic inflammation. Whole grains and probiotics play a protective role against CRC. Fermented grains are receiving increased attention due to their anti-inflammatory and anti-cancer activities. Our previous study found that a combination of germinated brown rice (GBR) with probiotics suppressed colorectal carcinogenesis in rats. However, the cancer-preventive effect of probiotic-fermented GBR has not been reported. This study investigated the preventive effect and possible mechanism of GBR fermented by Lactobacillus acidophilus (FGBR) on colorectal carcinogenesis in rats induced by 1,2-dimethylhydrazine (DMH) and dextran sulfate sodium (DSS). DMH/DSS treatment induced preneoplastic aberrant crypt foci (ACF), elevated serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β, as well as decreased pro-apoptotic Bax expression. GBR and FGBR reduced the primary ACF number and decreased TNF-α, IL-6 and IL-1β levels. GBR and FGBR at the 2.5% level increased pro-apoptotic cleaved caspase-3 and decreased anti-apoptotic B-cell lymphoma 2 (Bcl-2) expressions. FGBR at the 2.5% level further reduced the number of sialomucin-producing ACF (SIM-ACF) and increased Bax expression. These results suggest that FGBR may inhibit preneoplastic lesions of the colon via activating the apoptotic pathway. This fermented rice product may have the potential to be developed as a novel dietary supplement for CRC chemoprevention.

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“…γ‐Oryzanol has been shown to exhibit anti‐inflammatory, antihyperlipoproteinaemic, and cholesterol‐lowering and platelet aggregation lowering properties []. Germination increased the γ‐oryzanol content and cancer cell‐inhibiting effects of brown rice []. Fermented brown rice and rice bran prevented induced colorectal carcinogenesis [] and lung tumorigenesis [] in mice.…”

Section: Introductionmentioning

confidence: 99%