The challenges of testing metal and metal oxide nanoparticles in algal bioassays: titanium dioxide and gold nanoparticles as case studies

Hartmann, Nanna B.; Engelbrekt, Christian; Zhang, Jingdong; Ulstrup, Jens; Kusk, Kresten Ole; Baun, Anders

doi:10.3109/17435390.2012.710657

Cited by 65 publications

(67 citation statements)

References 32 publications

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“…A tendency to more stable test suspensions was however seen when for M7 + SR-NOM medium prepared from TiO 2 ENP Stock I (in MilliQ water). As a result of media composition (especially the presence of divalent cations) TiO 2 ENPs spontaneously agglomerated upon transfer to medium (Table 1), as previously shown by other studies [24,44]. Interactions of media constituents can modify the chemistry and behavior of TiO 2 ENPs in aqueous suspension as agglomeration has been reported for CaCl 2 concentrations over 0.1 mM, and pH above 5 [45] which are conditions fulfilled by the M7 medium.…”

Section: Characterization and Behavior Of Ag Zno Tio 2 Enps In Suspsupporting

confidence: 73%

“…Different ENPs behave differently under the same test conditions. TiO 2 ENPs tend to agglomerate in aquatic suspensions [24], and ZnO [5,9] and Ag [25,26] undergo dissolution. Therefore, a case-by-case consideration of possible alterations to the OECD guideline protocols is required in order to optimize suspension stability while minimizing test artifacts arising from the preparation procedure.…”

Section: Introductionmentioning

confidence: 99%

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The influence of natural organic matter and aging on suspension stability in guideline toxicity testing of silver, zinc oxide, and titanium dioxide nanoparticles with Daphnia magna

Cupi

Hartmann

Baun

2015

Enviro Toxic and Chemistry

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106

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The present study investigated changes in suspension stability and ecotoxicity of engineered nanoparticles (ENPs) by addition of Suwannee River natural organic matter and aging of stock and test suspensions prior to testing. Acute toxicity tests of silver (Ag), zinc oxide (ZnO), and titanium dioxide (TiO2) ENPs with Daphnia magna were carried out following Organisation for Economic Co‐operation and Development test guidelines. Daphnia magna was found to be very sensitive to Ag ENPs (48‐h 50% effective concentration 33 μg L−1), and aging of the test suspensions in M7 medium (up to 48 h) did not decrease toxicity significantly. Conversely, the presence of Suwannee River natural organic matter (NOM; 20 mg L−1) completely alleviated Ag ENP toxicity in all testing scenarios and did not aid in stabilizing suspensions. In contrast, addition of Suwannee River NOM stabilized ZnO ENP suspensions and did not decrease toxicity. Aging for 48 h generated monotonous concentration–response curves in the presence and absence of Suwannee River NOM. At concentrations up to 100 mg L−1 TiO2 ENPs did not cause immobilization of D. magna under any of the tested conditions. Presence of Suwannee River NOM caused agglomeration in stock suspensions. The authors' results suggest that aging and presence of Suwannee River NOM are important parameters in standard toxicity testing of ENPs, which in some cases may aid in gaining better control over the exposure conditions but in other cases might contribute to agglomeration or elimination of ENP toxicity. Therefore, modifications to the current guidelines for testing ENPs should be evaluated on a case‐by‐case basis. Environ Toxicol Chem 2015;34:497–506. © 2014 SETAC

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Section: Characterization and Behavior Of Ag Zno Tio 2 Enps In Suspsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

The influence of natural organic matter and aging on suspension stability in guideline toxicity testing of silver, zinc oxide, and titanium dioxide nanoparticles with Daphnia magna

Cupi

Hartmann

Baun

2015

Enviro Toxic and Chemistry

Self Cite

106

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“…filtered or unfiltered, use of solvent), the com-bination of different materials with varying testing condition, the expo-sure time and the exposure under UV radiation. And more, aquatic toxicology of nano-TiO2 is challenged by methodological difficulties arising from highly dynamic and poorly understood behaviour of ENPs in biological test systems (Hartmann et al, 2013). One target of application of nano-TiO2 is photochemical degradation of contaminants and photo-killing of microbes due to its strong photoreactivity.…”

Section: The Effect Factor For Nano-tio2mentioning

confidence: 99%

Freshwater ecotoxicity characterisation factor for metal oxide nanoparticles: A case study on titanium dioxide nanoparticle

Salieri

Righi

Pasteris

et al. 2015

Science of The Total Environment

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“…Particle properties and behaviour may change as a function of time or as a result of interactions with test organisms and emitted biomolecules (e.g. exudates) [7]. It has therefore been recognised as essential in the work with engineered nanomaterials to conduct a particle and exposure characterisation before and during a laboratory test [26,92].…”

Section: Nano-and Microplastics In Standard Ecotoxicity Testsmentioning

confidence: 99%

“…Particles as emerging environmental pollutants call for a better understanding of their environmental behaviour and potentially harmful effects on organisms. Ecotoxicity testing of particles represents a shift in test paradigm away from testing of soluble chemicals and demands reconsideration of existing test methods and procedures, including the standardised methods developed by OECD and ISO [7,8]. On the one hand, parallels can generally be drawn between ecotoxicological testing of particles, independent of whether those particles are engineered nanomaterials or plastic particles [9].…”

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confidence: 99%

Aquatic Ecotoxicity of Microplastics and Nanoplastics: Lessons Learned from Engineered Nanomaterials

Rist

Hartmann

2017

The Handbook of Environmental Chemistry

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The widespread occurrence of microplastics in the aquatic environment is well documented through international surveys and scientific studies. Further degradation and fragmentation, resulting in the formation of nanosized plastic particles -nanoplastics -has been highlighted as a potentially important issue. In the environment, both microplastics and nanoplastics may have direct ecotoxicological effects, as well as vector effects through the adsorption of co-contaminants. Plastic additives and monomers may also be released from the polymer matrix and cause adverse effects on aquatic organisms. Although limited information regarding the ecotoxicological effects of nano-and microplastics is available at present, their small size gives rise to concern with respect to the adverse effects and dislocation of these particles inside organisms -similar to issues often discussed for engineered nanomaterials. In the same way, transport of co-contaminants and leaching of soluble substances are much debated issues with respect to the ecotoxicology of nanomaterials.In this chapter, we draw on existing knowledge from the field of ecotoxicology of engineered nanomaterials to discuss potential ecotoxicological effects of nanoand microplastics. We discuss the similarities and differences between nano-and microplastics and engineered nanomaterials with regard to both potential effects and expected behaviour in aquatic media. One of the key challenges in ecotoxicology of nanomaterials has been the applicability of current test methods, originally intended for soluble chemicals, to the testing of particle suspensions. This often requires test modifications and special attention to physical chemical characterisation and data interpretation. We present an overview of lessons learned from This chapter has been externally peer-reviewed.

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The challenges of testing metal and metal oxide nanoparticles in algal bioassays: titanium dioxide and gold nanoparticles as case studies

Cited by 65 publications

References 32 publications

The influence of natural organic matter and aging on suspension stability in guideline toxicity testing of silver, zinc oxide, and titanium dioxide nanoparticles with Daphnia magna

The influence of natural organic matter and aging on suspension stability in guideline toxicity testing of silver, zinc oxide, and titanium dioxide nanoparticles with Daphnia magna

Freshwater ecotoxicity characterisation factor for metal oxide nanoparticles: A case study on titanium dioxide nanoparticle

Aquatic Ecotoxicity of Microplastics and Nanoplastics: Lessons Learned from Engineered Nanomaterials

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