The challenges of early diagnosis and therapeutic prediction in rheumatoid arthritis

Zhao, Jinxia; Li, Zhanguo

doi:10.1111/1756-185x.13459

Cited by 13 publications

(7 citation statements)

References 39 publications

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“…Clinically, it manifests as symmetrical, persistent joint swelling and tenderness around the diseased joints. In the later stages, RA will cause severe damage to joint function, and even lead to physical disability of the patient (25,26). Since RA causes irreversible bone destruction, treatment is aimed at inhibiting or reducing this irreversible bone destruction and protecting the patient's joint mobility to the greatest extent.…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta-analysis on the efficacy of methotrexate in rheumatoid arthritis

Jiang

Jin

Chen³

et al. 2021

Ann Palliat Med

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Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease dominated by chronic inflammation of the synovium of the joints. Methotrexate (MTX) is the most widely used in the treatment of RA. This study systematically evaluated the clinical efficacy of MTX on RA and provided a theoretical basis for the clinical treatment of RA.Methods: Four English databases (PubMed, Embase, Medline, and Web of Sciences) were searched for randomized controlled trials (RCTs) on MTX treatment of RA published from the date of establishment of the database to 2021. The Cochrane Handbook 5.0.2 was used to perform risk bias evaluation and Review Manager 5.3 was used to conduct a meta-analysis.Results: A total of eight articles were included. The meta-analysis showed that, compared to the control group, the number of patients with DAS28-ESR ≤2.6 [erythrocyte sedimentation rate (ESR)] in the MTX alone or MTX combined treatment groups was higher, and the incidence of adverse events was also higher.However, there was no significant difference in the level of alanine aminotransferase (ALT) after treatment versus the control group.Discussion: MTX alone or MTX combined treatment can better control the condition of RA patients without causing damage to the patient's blood system or liver and kidney function, but may increase the probability of adverse events.

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Section: Discussionmentioning

confidence: 99%

Systematic review and meta-analysis on the efficacy of methotrexate in rheumatoid arthritis

Jiang

Jin

Chen³

et al. 2021

Ann Palliat Med

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“…However, as a result of early diagnosis, aggressive treatment, and widespread use of conventional and biological disease-modifying antirheumatic drugs (DMARDs), the long-term prognosis has improved over the past two decades (2)(3)(4)(5). Rheumatoid arthritis development goes through the several stages: starting from the interplay of the genetic predisposition and environmental factors, develops through the epigenetic and post-translational modifications, followed by preclinical asymptomatic inflammation and autoimmunity, ending as the clinically overt arthritis (6).…”

Section: Rheumatoid Arthritis and Obesity Role Of Adipokinesmentioning

confidence: 99%

The Role of Leptin and Adiponectin in Rheumatoid Arthritis

Mikic¹,

Jakovljević

Veselinović

2023

Experimental and Applied Biomedical Research (EABR)

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Rheumatoid arthritis (RA) is an autoimmune systemic inflammatory disease, characterized by chronic synovial inflammation and destruction of cartilage and bone, results in varying degrees of deformity and functional disability. Previous research has shown that there is a link between adipokines and RA, but also other systemic diseases such as cardiovascular disease and diabetes mellitus. Adipokines are biologically active substances, which are predominantly or exclusively secreted from adipocytes of adipose tissue, or other adipose tissue cells such as: preadipocytes, immune cells infiltrated in AT, or other cell types within this tissue. These molecules play a significant role in energy homeostasis and metabolism regulation, and are also involved in chronic inflammation and metabolic dysfunctions. Some of the adipokines act like hormones in glucose homeostasis and appetite regulation, while others, like cytokines, support the link between obesity and insulin resistance with the immune system and the inflammatory process. However, the clear role of adipokines in pathological conditions has not yet been established. This review will focus on current knowledge about the role of the two most prominent adipokines, leptin and adiponectin, in the pathogenesis of RA.

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“…Although a plethora of anti‐inflammatory medications is available, early initiation of therapy is recommended to minimize the possibilities of disability and reduce the complications and morbidities of RA, to achieve better outcomes 13,14 . Therefore, early detection of RA in asymptomatic patients has become a top research priority 15 . Cytokines and chemokines are pro‐inflammatory agents released in the synovia and sera of RA patients 16 .…”

Section: Introductionmentioning

confidence: 99%

“…13,14 Therefore, early detection of RA in asymptomatic patients has become a top research priority. 15 Cytokines and chemokines are pro-inflammatory agents released in the synovia and sera of RA patients. 16 The detection of certain cytokines and/or chemokines has significant predictive power in patients not previously diagnosed with RA and without any apparent significant features of the rheumatoid disorder.…”

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confidence: 99%

Assessment of IL‐1β, IL‐6, TNF‐α, IL‐8, and CCL 5 levels in newly diagnosed Saudi patients with rheumatoid arthritis

Alturaiki

Alhamad

Alturaiqy³

et al. 2022

Int J of Rheum Dis

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Background Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder which mainly affects small joints, occurs most commonly in middle‐aged adults, and can be fatal in severe cases. The exact etiology of RA remains unknown. However, uncontrolled expression of pro‐inflammatory cytokines and chemokines can contribute to the pathogenesis of RA. Aim In the current study, we assessed the potential of serum concentrations of interleukin (IL)‐1β, IL‐6, tumor necrosis factor (TNF)‐α, IL‐8, and C‐C motif chemokine ligand (CCL)5 as early predictive markers for RA. Methods In addition to clinical examination, blood samples were collected from 100 Saudi patients recently diagnosed with early RA for basic and serological tests, including rheumatoid factor (RF), C‐reactive protein (CRP), and erythrocyte sedimentation rate (ESR). Sera of 32 healthy individuals were used as controls. Specific enzyme‐linked immunosorbent assay was used to quantify the serum IL‐1β, IL‐6, TNF‐α, IL‐8, and CCL5 levels in the samples. Results Our results indicated that RF, CRP, and ESR levels were higher in RA patients compared to controls. Furthermore, serum levels of IL‐1β, IL‐6, IL‐8, and CCL5, but not TNF‐α, significantly increased in RA patients compared to controls. Conclusion Overall, the findings suggested that IL‐1β, IL‐6, IL‐8, and CCL5 can be used as biomarkers in the early diagnosis of RA.

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The challenges of early diagnosis and therapeutic prediction in rheumatoid arthritis

Cited by 13 publications

References 39 publications

Systematic review and meta-analysis on the efficacy of methotrexate in rheumatoid arthritis

Systematic review and meta-analysis on the efficacy of methotrexate in rheumatoid arthritis

The Role of Leptin and Adiponectin in Rheumatoid Arthritis

Assessment of IL‐1β, IL‐6, TNF‐α, IL‐8, and CCL 5 levels in newly diagnosed Saudi patients with rheumatoid arthritis

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