The challenge to improve the response of biomaterials to the physiological environment

Peppas, Nicholas A.; Clegg, John R.

doi:10.1093/rb/rbw012

Cited by 20 publications

(11 citation statements)

References 23 publications

(26 reference statements)

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“…The range of advanced biomaterial characteristics currently available in hydrogels may translate to novel scaffold surface modifications ( Figure 5). These advanced characteristics include environmentally responsive hydrogels, gels that can present varying degrees of surface elasticity, molecularly imprinted polymers, cellularly imprinted polymers, and more (Clegg, Wechsler, & Peppas, 2017;Culver, Clegg, & Peppas, 2017;Engler, Sen, Sweeney, & Discher, 2006;Peppas & Clegg, 2016). Such modifications will provide opportunities for more finely tuned characterization of cell responses to properties such as dynamic mechanical moduli and advanced controlled release of growth factors.…”

Section: Figurementioning

confidence: 99%

Tuning the biomimetic behavior of scaffolds for regenerative medicine through surface modifications

Richbourg

Peppas

Sikavitsas

2019

J Tissue Eng Regen Med

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115

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Tissue engineering and regenerative medicine rely extensively on biomaterial scaffolds to support cell adhesion, proliferation, and differentiation physically and chemically in vitro and in vivo. Changes to the surface characteristics of the scaffolds have the greatest impact on cell response. Here, we discuss five dominant surface modification approaches used to biomimetically improve the most common scaffolds for tissue engineering, those based on aliphatic polyesters. Scaffolds of aliphatic polyesters such as poly(L-lactic acid), poly(L-lactic-co-glycolic acid), and poly(ε-caprolactone) are often used in tissue engineering because they provide desirable, tunable properties such as ease of manufacturing, good mechanical properties, and nontoxic degradation products. However, cell–surface interactions necessary for tissue engineering are limited on these materials by their smooth postfabrication surfaces, hydrophobicity, and lack of recognizable biochemical binding sites. The surface modification techniques that have been developed for synthetic polymer scaffolds reduce initial barriers to cell adhesion, proliferation, and differentiation. Topographical modification, protein adsorption, mineral coating, functional group incorporation, and biomacromolecule immobilization each contribute through varying mechanisms to improving cell interactions with aliphatic polyester scaffolds. Furthermore, rational combination of methods from these categories can provide nuanced, specific environments for targeted tissue development.

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Section: Figurementioning

confidence: 99%

Tuning the biomimetic behavior of scaffolds for regenerative medicine through surface modifications

Richbourg

Peppas

Sikavitsas

2019

J Tissue Eng Regen Med

Self Cite

150

115

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“…Some additional aspects of biopolymer polymeric design have been recently discussed by Peppas and Clegg. 100 Molecular imprinting will especially be relevant for scaffold-based strategies (Fig. 4) as they depend on scaffold bioactivity to modulate cell activity in situ.…”

Section: Final Remarks and Future Prospectsmentioning

confidence: 99%

Molecularly Imprinted Intelligent Scaffolds for Tissue Engineering Applications

Neves

Wechsler

Gomes

et al. 2017

Tissue Engineering Part B: Reviews

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The development of molecularly imprinted polymers (MIPs) using biocompatible production methods enables the possibility to further exploit this technology for biomedical applications. Tissue engineering (TE) approaches use the knowledge of the wound healing process to design scaffolds capable of modulating cell behavior and promote tissue regeneration. Biomacromolecules bear great interest for TE, together with the established recognition of the extracellular matrix, as an important source of signals to cells, both promoting cell-cell and cell-matrix interactions during the healing process. This review focuses on exploring the potential of protein molecular imprinting to create bioactive scaffolds with molecular recognition for TE applications based on the most recent approaches in the field of molecular imprinting of macromolecules. Considerations regarding essential components of molecular imprinting technology will be addressed for TE purposes. Molecular imprinting of biocompatible hydrogels, namely based on natural polymers, is also reviewed here. Hydrogel scaffolds with molecular memory show great promise for regenerative therapies. The first molecular imprinting studies analyzing cell adhesion report promising results with potential applications for cell culture systems, or biomaterials for implantation with the capability for cell recruitment by selectively adsorbing desired molecules.

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“…Nowadays, there is a real need to seek out more efficient systems for the diagnosis and treatment of many diseases and hence achieve better overall health in our society. Sensitive nanomaterials that can respond to exact stimuli are part of an important strategy in many biomedical fields like drug delivery, biosensing, and biomaterials [1,2] These materials can be functionalized to respond to temperature, pH, light, electric field, magnetic field, radiofrequency and ultrasound, amongst many others [3,4]. Specifically, thermosensitive nanomaterials are promising in disease treatment and diagnosis due to their capacity to aim at pre-selected sites when simulated in a certain temperature range [5].…”

Section: Introductionmentioning

confidence: 99%

Clinical Trials of Thermosensitive Nanomaterials: An Overview

et al. 2019

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Currently, we are facing increasing demand to develop efficient systems for the detection and treatment of diseases that can realistically improve distinct aspects of healthcare in our society. Sensitive nanomaterials that respond to environmental stimuli can play an important role in this task. In this manuscript, we review the clinical trials carried out to date on thermosensitive nanomaterials, including all those clinical trials in hybrid nanomaterials that respond to other stimuli (e.g., magnetic, infrared radiation, and ultrasound). Specifically, we discuss their use in diagnosis and treatment of different diseases. At present, none of the existing trials focused on diagnosis take advantage of the thermosensitive characteristics of these nanoparticles. Indeed, almost all clinical trials consulted explore the use of Ferumoxytol as a current imaging test enhancer. However, the thermal property is being further exploited in the field of disease treatment, especially for the delivery of antitumor drugs. In this regard, ThermoDox®, based on lysolipid thermally sensitive liposome technology to encapsulate doxorubicin (DOX), is the flagship drug. In this review, we have evidenced the discrepancy existing between the number of published papers in thermosensitive nanomaterials and their clinical use, which could be due to the relative novelty of this area of research; more time is needed to validate it through clinical trials. We have no doubt that in the coming years there will be an explosion of clinical trials related to thermosensitive nanomaterials that will surely help to improve current treatments and, above all, will impact on patients’ quality of life and life expectancy.

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The challenge to improve the response of biomaterials to the physiological environment

Cited by 20 publications

References 23 publications

Tuning the biomimetic behavior of scaffolds for regenerative medicine through surface modifications

Tuning the biomimetic behavior of scaffolds for regenerative medicine through surface modifications

Molecularly Imprinted Intelligent Scaffolds for Tissue Engineering Applications

Clinical Trials of Thermosensitive Nanomaterials: An Overview

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