The Challenge of Improving Donor Heart Preservation

McCrystal, Graham; Pepe, Salvatore; Esmore, Donald; Rosenfeldt, Franklin

doi:10.1016/j.hlc.2004.01.027

Cited by 14 publications

(4 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cold preservation solutions are commonly used protective media to keep the donor organs in good condition during whole ischemic time. Good preservation prevents ischemic damages and reperfusion injury and minimizes cellular damage [16]. …”

Section: Discussionmentioning

confidence: 99%

Is there any cardioprotective role of Taurine during cold ischemic period following global myocardial ischemia?

Şahin

Yücel

Güler

et al. 2011

J Cardiothorac Surg

View full text Add to dashboard Cite

BackgroundThe aim of the present study was to investigate the cardioprotective effect of Taurine on the donor hearts during cold ischemic period.Methods32 rats were divided into four groups (sham, taurine, ischemia, treatment group, 8 rats in each). All rats were fed with rat food for three weeks. Taurine and treatment groups were given a 200 mg/kg/day dose of Taurine by oral gavage besides rat feed. Cardiectomy was performed in all rats after three weeks. In ischemia and treatment groups, harvested hearts were kept in 0.9% sodium chloride at +4 degrees C for 5 hours. Tissue samples were taken from left ventricle in all groups. These samples were evaluated by histopathologic and biochemical examination.ResultsIn the present study results of the biochemical and histopathological examination reveals the protective effects of Taurine. As a marker of lipid peroxidation, Malondialdehyde (MDA) levels in ischemia group were significantly higher than both Sham and Taurine groups. MDA values were recorded; 3.62 ± 0.197 in the sham group, 2.07 ± 0.751 in the Taurine group, 9.71 ± 1.439 in the ischemia group and 7.68 ± 1.365 in the treatment group. MDA levels decreased in treatment group. (p < 0.05) In accordance with MDA findings, while superoxide dismutase and glutathione peroxidase levels decreased in ischemia group, they increased in treatment group. (p < 0.05) There was no differences in Catalase (CAT) enzyme level between treatment and ischemia group (p = 1.000). CAT level results were recorded; 7.08 ± 0.609 in the sham group, 6.15 ± 0.119 in the Taurine group, 5.02 ± 0.62 in the ischemia group, and 5.36 ± 0.384 in the treatment group. Less intracellular edema and inflammatory cell reaction were observed in histologic examination in favor of treatment group. (p < 0.01)ConclusionTaurine decreased myocardial damage during cold ischemic period following global myocardial ischemia.

show abstract

Section: Discussionmentioning

confidence: 99%

Is there any cardioprotective role of Taurine during cold ischemic period following global myocardial ischemia?

Şahin

Yücel

Güler

et al. 2011

J Cardiothorac Surg

View full text Add to dashboard Cite

show abstract

“…The endothelium is however important as it locally regulates coronary perfusion and cardiac function through the secretion of nitric oxide and vasoactive peptides. Therefore, after administration of a high potassium concentration solution, endothelial dysfunction occurs, which could lead to myocardial dysfunction [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of HTK-Custodiol and St-Thomas solution as cardiac preservation solutions on early and midterm outcomes following heart transplantation

Dulguerov,

Abdurashidowa,

Christophel-Plathier

et al. 2024

Interdisciplinary CardioVascular and Thoracic Surgery

View full text Add to dashboard Cite

OBJECTIVES The choice of the cardiac preservation solution for myocardial protection at time of heart procurement remains controversial and uncertainties persist regarding its effect on the early and midterm heart transplantation (HTx) outcomes. We retrospectively compared our adult HTx performed with 2 different solutions, in terms of hospital mortality, mid-term survival, inotropic score, primary graft dysfunction and rejection score. METHODS From January 2009 to December 2020, 154 consecutive HTx of adult patients, followed up in pre- and post-transplantation by 2 different tertiary centres, were performed at the University Hospital of Lausanne, Switzerland. From 2009 to 2015, the cardiac preservation solution used was exclusively St-Thomas, whereafter an institutional decision was made to use HTK-Custodiol only. Patients were classified in 2 groups accordingly. RESULTS There were 75 patients in the St-Thomas group and 79 patients in the HTK-Custodiol group. The 2 groups were comparable in terms of preoperative and intraoperative characteristics. Postoperatively, compared to the St-Thomas group, the Custodiol group patients showed significantly lower inotropic scores [median (interquartile range): 35.7 (17.5–60.2) vs 71.8 (31.8–127), P < 0.001], rejection scores [0.08 (0.0–0.25) vs 0.14 (0.05–0.5), P = 0.036] and 30-day mortality rate (2.5% vs 14.7%, P = 0.007) even after adjusting for potential confounders. Microscopic analysis of the endomyocardial biopsies also showed less specific histological features of subendothelial ischaemia (3.8% vs 17.3%, P = 0.006). There was no difference in primary graft dysfunction requiring postoperative extracorporeal membrane oxygenation. The use of HTK-Custodiol solution significantly improved midterm survival (Custodiol versus St-Thomas: hazard ratio = 0.20, 95% confidence interval: 0.069–0.60, P = 0.004). CONCLUSIONS This retrospective study comparing St-Thomas solution and HTK-Custodiol as myocardial protection during heart procurement showed that Custodiol improves outcomes after HTx, including postoperative inotropic score, rejection score, 30-day mortality and midterm survival.

show abstract

“…A tolerância de até 4 horas entre a retirada do coração do doador e a sua reperfusão representa importante desafio 158 . Acima desse tempo, o coração apresenta alterações estruturais que podem comprometer o sucesso do procedimento 159,160 . Todavia, bons resultados têm sido relatados com períodos de isquemia maiores, a despeito do aumento dos gastos hospitalares e do maior período de internação 161 .…”

Section: Aspectos Cirúrgicos Do Transplante Cardíaco A) Captação unclassified

II Diretriz Brasileira de Transplante Cardíaco

Moreira

2010

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

Declaração obrigatória de conflito de interesses Nos últimos três anos, o autor/colaborador da diretriz: Nome do médico Participou de estudos clínicos e/ou experimentais subvencionados pela indústria farmacêutica ou de equipamentos relacionados à diretriz em questão Foi palestrante em eventos ou atividades patrocinadas pela indústria relacionados à diretriz em questão Foi (é) membro do conselho consultivo ou diretivo da indústria farmacêutica ou de equipamentos Participou de comitês normativos de estudos científicos patrocinados pela indústria Recebeu auxílio pessoal ou institucional da indústria Elaborou textos científicos em periódicos

show abstract

The Challenge of Improving Donor Heart Preservation

Cited by 14 publications

References 73 publications

Is there any cardioprotective role of Taurine during cold ischemic period following global myocardial ischemia?

Is there any cardioprotective role of Taurine during cold ischemic period following global myocardial ischemia?

Comparison of HTK-Custodiol and St-Thomas solution as cardiac preservation solutions on early and midterm outcomes following heart transplantation

II Diretriz Brasileira de Transplante Cardíaco

Contact Info

Product

Resources

About