2021
DOI: 10.26420/annhematoloncol.2021.1362
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The Challenge of Diagnosing Heparin-Induced Thrombocytopenia with Negative Immunologic and Functional Assays

Abstract: Heparin-Induced Thrombocytopenia (HIT) is a prothrombotic and potentially fatal immune complication of heparin therapy. HIT is challenging to diagnose, particularly in critically ill patients where multiple causes of thrombocytopenia must be considered. Diagnostic algorithms for HIT begin with a clinical assessment, followed by laboratory testing when indicated. If Platelet Factor-4 (PF4)/heparin immunoassay and Serotonin Release Assays (SRA) are negative, HIT is deemed unlikely and heparin therapy may be resu… Show more

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