“…Unlike most prior studies, we used an semi-automated, objective method to quantify DWMA. To our knowledge, only one other group has developed an algorithm to accurately segment DWMA ( Xu et al, 2018 ), however it has not been validated with clinical outcomes like our algorithm ( Parikh et al, 2020bb , Parikh, 2020 ). Furthermore, by using graph theory rather than diffusion metrics alone, we were able to identify high-level network changes associated with DWMA extent.…”