The Challenge of Bringing iPSCs to the Patient

Ortuño-Costela, María del Carmen; Cerrada, Victoria; García-López, Marta; Gallardo, M. Esther

doi:10.3390/ijms20246305

Cited by 46 publications

(35 citation statements)

References 106 publications

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“…Currently, clinical-grade iPSC haplobanks are already available in South Korea and Japan (16,19,20,26) and similar initiatives are being undertaken in other countries such as Australia (27). The effectiveness of the approach will come from a global collaborative to share haplolines and this implies an effort to standardize the production and quality control by the different banks (28,29).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Spanish Population Coverage of a Prospective HLA Haplobank of Induced Pluripotent Stem Cells.

Álvarez-Palomo

Garcia-Martínez

Gayoso

et al. 2020

Preprint

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Background iPSC (Induced Pluripotent Stem Cells) banks of iPSC lines with homozygous HLA (Human Leukocyte Antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic transplantation of iPSC derived cell therapies. Cord blood banks offer an extensive source of HLA-typed cells suitable for reprogramming to iPSC. Several initiatives worldwide have been undertaken to create national and international iPSC haplobanks that match a significant part of a population. Methods To create an iPSC haplobank that serves the Spanish population (IPS-PANIA), we have searched the Spanish Bone Marrow Donor Registry (REDMO) to identify the most frequently estimated haplotypes. From the top ten donors identified, we estimated the population coverage using the criteria of zero mismatches in HLA-A, -B and -DRB1 with different stringencies: high resolution, low resolution and beneficial mismatch. Results We have calculated that ten cord blood units from homozygous donors stored at the Spanish cord blood banks can provide a HLA-A, HLA-B and HLA-DRB1 matching for 28,23% of the population. Conclusion We confirm the feasibility of using banked cord blood units to create an iPSC haplobank that will cover a significant percentage of the Spanish and international population for future advanced therapy replacement strategies.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Spanish Population Coverage of a Prospective HLA Haplobank of Induced Pluripotent Stem Cells.

Álvarez-Palomo

Garcia-Martínez

Gayoso

et al. 2020

Preprint

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“…Some reviews have summarized the applications of iPSCs in cell therapies [136]. Most previous attempts aimed to use iPSCs after differentiation into specific cell types, mainly NSCs.…”

Section: Merits and Hurdles Of Using Induced Pluripotent Stem Cells Fmentioning

confidence: 99%

Recent Advances in Cell-Based Therapies for Ischemic Stroke

Suda

Nito

Yokobori

et al. 2020

IJMS

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Stroke is the most prevalent cardiovascular disease worldwide, and is still one of the leading causes of death and disability. Stem cell-based therapy is actively being investigated as a new potential treatment for certain neurological disorders, including stroke. Various types of cells, including bone marrow mononuclear cells, bone marrow mesenchymal stem cells, dental pulp stem cells, neural stem cells, inducible pluripotent stem cells, and genetically modified stem cells have been found to improve neurological outcomes in animal models of stroke, and there are some ongoing clinical trials assessing their efficacy in humans. In this review, we aim to summarize the recent advances in cell-based therapies to treat stroke.

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“…However, immunogenicity still remains as a drawback tried to be solved through donors who are homozygous at human leukocyte antigen alleles namely "super donors". Fortunately, encouraging efforts have come from the United States, European Union, and Japan in recent years in order to expedite approval processes for translation of stem cell therapies into the clinics including PSCs [147,148].…”

Section: Stem Cell Typementioning

confidence: 99%

Therapeutic Applications of Stem Cells and Extracellular Vesicles in Emergency Care: Futuristic Perspectives

Öztürk

Elçin

Koca

et al. 2020

Stem Cell Rev and Rep

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Regenerative medicine (RM) is an interdisciplinary field that aims to repair, replace or regenerate damaged or missing tissue or organs to function as close as possible to its physiological architecture and functions. Stem cells, which are undifferentiated cells retaining self-renewal potential, excessive proliferation and differentiation capacity into offspring or daughter cells that form different lineage cells of an organism, are considered as an important part of the RM approaches. They have been widely investigated in preclinical and clinical studies for therapeutic purposes. Extracellular vesicles (EVs) are the vital mediators that regulate the therapeutic effects of stem cells. Besides, they carry various types of cargo between cells which make them a significant contributor of intercellular communication. Given their role in physiological and pathological conditions in living cells, EVs are considered as a new therapeutic alternative solution for a variety of diseases in which there is a high unmet clinical need. This review aims to summarize and identify therapeutic potential of stem cells and EVs in diseases requiring acute emergency care such as trauma, heart diseases, stroke, acute respiratory distress syndrome and burn injury. Diseases that affect militaries or societies including acute radiation syndrome, sepsis and viral pandemics such as novel coronavirus disease 2019 are also discussed. Additionally, featuring and problematic issues that hamper clinical translation of stem cells and EVs are debated in a comparative manner with a futuristic perspective.

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The Challenge of Bringing iPSCs to the Patient

Cited by 46 publications

References 106 publications

Evaluation of the Spanish Population Coverage of a Prospective HLA Haplobank of Induced Pluripotent Stem Cells.

Evaluation of the Spanish Population Coverage of a Prospective HLA Haplobank of Induced Pluripotent Stem Cells.

Recent Advances in Cell-Based Therapies for Ischemic Stroke

Therapeutic Applications of Stem Cells and Extracellular Vesicles in Emergency Care: Futuristic Perspectives

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