Abstract:The
cytosolic iron sulfur cluster assembly (CIA) scaffold biosynthesizes
iron sulfur cluster cofactors for enzymes residing in the cytosol
and the nucleus. In fungi and animals, it comprises two homologous
ATPases, called Nbp35 and Cfd1 in yeast, which can form homodimeric
and heterodimeric complexes. Both proteins are required for CIA function,
but their individual roles are not well understood. Here we investigate
the nucleotide affinity of each form of the scaffold for ATP and ADP
to reveal any differences … Show more
An ENU screen identifies a novel allele of Nubp2 which is then demonstrated to be required for cranial neural crest survival and proper midfacial development.
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