The end of the Cretaceous saw the Western Interior Seaway divide North America into two land masses, Laramidia in the west and Appalachia in the east. Laramidian dinosaurs inhabited a narrow strip of land extending from Mexico to Alaska. Within this geographically restricted area, dinosaurs evolved high diversity and endemism, with distinct species in the north and south. Here, we report a new tyrannosaurid from the Late Campanian-aged Cerro del Pueblo Formation of Coahuila, Mexico, which is part of a tribe of tyrannosaurs originating in southern Laramidia. Phylogenetic analysis recovers the new tyrannosaur as part of a clade including Labocania anomala from the La Bocana Roja Formation of Baja California Norte, Bistahieversor sealeyi from the Kirtland Formation of New Mexico, Teratophoneus curriei from the Kaiparowits Formation in Utah, and Dynamoterror dynastes from the Menefee Formation of New Mexico. Distinct frontal morphology and the younger age (~72.5–73 Ma versus >75.8 Ma for L. anomala) support recognition of the new tyrannosaur as a distinct species of Labocania, Labocania aguillonae. The Labocania clade dominated southern Laramidia at a time when the north was dominated by daspletosaurins and albertosaurines. The high endemism seen in tyrannosaurids is remarkable, given that modern apex predators have large geographic ranges and hints that the diversity of carnivorous dinosaurs has been underestimated.