The Cerebellum and Sleep

DelRosso, Lourdes M.; Hoque, Romy

doi:10.1016/j.ncl.2014.07.003

Cited by 71 publications

(59 citation statements)

References 22 publications

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“…This neglect is intriguing, because malfunction of the cerebellum does not only impair motor control and motor memory formation [6][7][8], but it may also lead to changes in the sleep-wake cycle [9,10] and even cause sleep disorders [11]. Furthermore, decades of behavioral and physiological research has shown the positive impact of sleep on episodic memory formation.…”

Section: The Cerebellum Is Still An 'Uncharted Land' In Sleep Researchmentioning

confidence: 99%

“…K-complexes are single slow waves occurring typically in NREM2. Spindles are short bursts of activity at a frequency of [10][11][12][13][14][15]. More continuous slow waves occur in what is considered deep sleep, NREM3, or SWS [12].…”

Section: Nrem-dependent Cerebellar Activitymentioning

confidence: 99%

“…Patients suffering from primary sleep disorders such as chronic insomnia, fatal familial insomnia, or obstructive sleep apnea accompanied by daytime sleepiness [65] show a decreased cerebellar volume [11,66]. Likewise, patients with REM sleep behavior disorder, which generates dream-enacting motor activity during REM, show a volumetric decrement in the anterior lobes of the cerebellar cortex and cerebellar nuclei [67,68].…”

Section: Sleep Disorders Can Lead To Cerebellar Malfunction and Vice mentioning

confidence: 99%

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The Sleeping Cerebellum

Canto

Onuki

Bruinsma

et al. 2017

Trends in Neurosciences

140

105

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We sleep almost one-third of our lives and sleep plays an important role in critical brain functions like memory formation and consolidation. The role of sleep in cerebellar processing, however, constitutes an enigma in the field of neuroscience; we know little about cerebellar sleep-physiology, cerebro-cerebellar interactions during sleep, or the contributions of sleep to cerebellum-dependent memory consolidation. Likewise, we do not understand why cerebellar malfunction can lead to changes in the sleep-wake cycle and sleep disorders. In this review, we evaluate how sleep and cerebellar processing may influence one another and highlight which scientific routes and technical approaches could be taken to uncover the mechanisms underlying these interactions.

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Section: The Cerebellum Is Still An 'Uncharted Land' In Sleep Researchmentioning

confidence: 99%

Section: Nrem-dependent Cerebellar Activitymentioning

confidence: 99%

Section: Sleep Disorders Can Lead To Cerebellar Malfunction and Vice mentioning

confidence: 99%

See 1 more Smart Citation

The Sleeping Cerebellum

Canto

Onuki

Bruinsma

et al. 2017

Trends in Neurosciences

140

105

View full text Add to dashboard Cite

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“…Similar findings were reported by Galbiati et al [57] since the effects of anodal tDCS applied to left DLPFC on arousal of patients with idiopathic hypersomnia during the 4 weeks/3 times/week reduced excessive daytime sleepiness. These results suggest that tDCS may modulate sleepiness in idiopathic patients [55][56][57]. Emerging research has demonstrated that application of slow oscillatory tDCS compared to sham-slow oscillatory tDCS decreased waking time [58][59][60].…”

Section: Transcranial Direct Current Stimulation For Insomniamentioning

confidence: 76%

“…Regarding the use of tDCS in insomnia, the role of prefronto-thalamic-cerebellar circuit on cognitive dysfunctions and sleep quality in euthymic bipolar disorder (BD) patients have showed that tDCS (2 mA) for 20 min/day during 3 consecutive weeks applied to left dorsolateral prefrontal cortex (DLPFC) and right cerebellar cortex improved sleep [54]. It has been suggested that DLPFC and cerebellum play a relevant role in modulating sleep [55,56]. Similar findings were reported by Galbiati et al [57] since the effects of anodal tDCS applied to left DLPFC on arousal of patients with idiopathic hypersomnia during the 4 weeks/3 times/week reduced excessive daytime sleepiness.…”

Section: Transcranial Direct Current Stimulation For Insomniamentioning

confidence: 99%

Alternative Strategies for Managing Insomnia: The Case of Physical Exercise and Transcranial Direct Current Stimulation. A Narrative Review

et al. 2018

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The sleep-wake cycle is a process regulated by multiple neurobiological mechanisms that in aberrant functioning provokes several sleep disturbances. Among the major categories of sleep disorders, insomnia represents one of the most reported in population. Pharmacological interventions aimed for treating this sleep disturbance include compounds such as antidepressants, antihistamines, sedative-hypnotics, among others. However, using pharmacological treatments increase undesirable side effects such as addiction to sleep-inducing drugs. Here, we review and summarize recent publications available in PubMed regarding the use of non-pharmacological/invasive means to control insomnia, including physical exercise and transcranial direct current stimulation (tDCS). Current data suggest that these two strategies efficiently manage insomnia, and in turn opens new approaches to develop therapeutical tools to diminish this pathology. Nevertheless, additional research is required to understand the neurobiological mechanism of action of physical exercise and tDCS in insomnia control.

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Functional connectivity of the human hypothalamus during wakefulness and nonrapid eye movement sleep

Jiang

Zou

Liu

et al. 2021

Human Brain Mapping

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Animal experiments indicate that the hypothalamus plays an essential role in regulating the sleep-wake cycle. A recent neuroimaging study conducted under resting wakefulness conditions suggested the presence of a wake-promoting region and a sleep-promoting region in the human posterior hypothalamus and anterior hypothalamus, respectively, and interpreted their anticorrelated organization in resting-state functional networks as evidence for their opposing roles in sleep-wake regulation.However, whether and how the functional networks of the two hypothalamic regions reorganize according to their wake-or sleep-promoting roles during sleep are unclear. Here, we constructed functional networks of the posterior and anterior hypothalamus during wakefulness and nonrapid eye movement (NREM) sleep using simultaneous electroencephalography and functional magnetic resonance imaging data collected from 62 healthy participants. The functional networks of the posterior and anterior hypothalamus exhibited inversely correlated organizations during both wakefulness and NREM sleep. The connectivity strength of the posterior hypothalamic functional network was stronger during wakefulness than during stable sleep.From wakefulness to sleep, the anterior cingulate gyrus, paracingulate gyrus, insular cortex, and fontal operculum cortex showed decreased positive connectivity, while the precentral gyrus and postcentral gyrus showed decreased negative connectivity with the posterior hypothalamus. Additionally, the insular cortex and frontal operculum cortex showed negative connectivity during wakefulness and positive connectivity during sleep with the anterior hypothalamus, exhibiting an increasing trend. These findings provide insights into the correspondence between the functional network organizations and hypothalamic sleep-wake regulation in humans.

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The Cerebellum and Sleep

Cited by 71 publications

References 22 publications

The Sleeping Cerebellum

The Sleeping Cerebellum

Alternative Strategies for Managing Insomnia: The Case of Physical Exercise and Transcranial Direct Current Stimulation. A Narrative Review

Functional connectivity of the human hypothalamus during wakefulness and nonrapid eye movement sleep

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